Crystal structure of Saccharomyces cerevisiae Aro8, a putative α‐aminoadipate aminotransferase

α‐Aminoadipate aminotransferase (AAA‐AT) catalyzes the amination of 2‐oxoadipate to α‐aminoadipate in the fourth step of the α‐aminoadipate pathway of lysine biosynthesis in fungi. The aromatic aminotransferase Aro8 has recently been identified as an AAA‐AT in Saccharomyces cerevisiae. This enzyme d...

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Veröffentlicht in:	Protein science 2013-10, Vol.22 (10), p.1417-1424
Hauptverfasser:	Bulfer, Stacie L., Brunzelle, Joseph S., Trievel, Raymond C.
Format:	Artikel
Sprache:	eng
Schlagworte:	2-Aminoadipate Transaminase - chemistry 2-Aminoadipate Transaminase - metabolism aminotransferase aromatic aminotransferase I Catalytic Domain - genetics Crystallography, X-Ray HEPES - metabolism Humans Lysine - metabolism lysine biosynthesis Models, Molecular multi‐substrate enzyme Protein Structure, Tertiary pyridoxal 5′‐phosphate Pyridoxal Phosphate - metabolism Pyridoxamine - analogs & derivatives Pyridoxamine - metabolism Saccharomyces cerevisiae - enzymology Saccharomyces cerevisiae Proteins - chemistry Saccharomyces cerevisiae Proteins - metabolism Substrate Specificity Thermus thermophilus - enzymology Transaminases - chemistry Transaminases - metabolism X‐ray crystallography
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