Identification of a Bis-molybdopterin Intermediate in Molybdenum Cofactor Biosynthesis in Escherichia coli

The molybdenum cofactor is an important cofactor, and its biosynthesis is essential for many organisms, including humans. Its basic form comprises a single molybdopterin (MPT) unit, which binds a molybdenum ion bearing three oxygen ligands via a dithiolene function, thus forming Mo-MPT. In bacteria,...

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Veröffentlicht in:	The Journal of biological chemistry 2013-10, Vol.288 (41), p.29736-29745
Hauptverfasser:	Reschke, Stefan, Sigfridsson, Kajsa G.V., Kaufmann, Paul, Leidel, Nils, Horn, Sebastian, Gast, Klaus, Schulzke, Carola, Haumann, Michael, Leimkühler, Silke
Format:	Artikel
Sprache:	eng
Schlagworte:	Biosynthesis Bis-MGD Coenzymes - biosynthesis Coenzymes - chemistry Coenzymes - metabolism Cofactor Assembly Dithiolene Enzymology Escherichia coli Escherichia coli - metabolism Escherichia coli Proteins - metabolism Guanosine Monophosphate - metabolism Humans Metalloproteins - biosynthesis Metalloproteins - chemistry Metalloproteins - metabolism Molecular Chaperone Molecular Chaperones - metabolism Molybdenum Molybdenum - chemistry Molybdenum - metabolism Oxidation-Reduction Oxidoreductases, N-Demethylating - metabolism Phosphates - chemistry Phosphates - metabolism Protein Binding Pteridines - chemistry Pteridines - metabolism Sulfurtransferases - metabolism Vitamins and Cofactors X-Ray Absorption Spectroscopy
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