Factor VIII C1 Domain Spikes 2092–2093 and 2158–2159 Comprise Regions That Modulate Cofactor Function and Cellular Uptake

The C1 domain of factor VIII (FVIII) has been implicated in binding to multiple constituents, including phospholipids, von Willebrand factor, and low-density lipoprotein receptor-related protein (LRP). We have previously described a human monoclonal antibody called KM33 that blocks these interaction...

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Veröffentlicht in:	The Journal of biological chemistry 2013-10, Vol.288 (41), p.29670-29679
Hauptverfasser:	Bloem, Esther, van den Biggelaar, Maartje, Wroblewska, Aleksandra, Voorberg, Jan, Faber, Johan H., Kjalke, Marianne, Stennicke, Henning R., Mertens, Koen, Meijer, Alexander B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Monoclonal - metabolism Antibodies, Monoclonal - pharmacology Binding Sites - genetics Deuterium Exchange Measurement Endocytosis Enzyme Kinetics Epitope Mapping Factor VIII Factor VIII - chemistry Factor VIII - genetics Factor VIII - metabolism Glycosylation Humans LDL-Receptor Related Proteins - chemistry LDL-Receptor Related Proteins - metabolism Mass Spectrometry Mass Spectrometry (MS) Models, Molecular Mutation Phosphatidylserines - chemistry Phosphatidylserines - metabolism Phospholipid Protein Binding - drug effects Protein Structure and Folding Protein Structure, Tertiary Surface Plasmon Resonance Surface Plasmon Resonance (SPR) von Willebrand Factor von Willebrand Factor - chemistry von Willebrand Factor - metabolism
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