Synthetic lethal targeting of PTEN-deficient cancer cells using selective disruption of polynucleotide kinase/phosphatase

A recent screen of 6,961 siRNAs to discover possible synthetic lethal partners of the DNA repair protein polynucleotide kinase/phosphatase (PNKP) led to the identification of the potent tumor suppressor phosphatase and tensin homolog deleted on chromosome 10 (PTEN). Here, we have confirmed the PNKP/...

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Veröffentlicht in:	Molecular cancer therapeutics 2013-10, Vol.12 (10), p.2135-2144
Hauptverfasser:	Mereniuk, Todd R, El Gendy, Mohamed A M, Mendes-Pereira, Ana M, Lord, Christopher J, Ghosh, Sunita, Foley, Edan, Ashworth, Alan, Weinfeld, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis - genetics Cell Line, Tumor DNA Breaks, Double-Stranded DNA Repair - genetics DNA Repair Enzymes - antagonists & inhibitors DNA Repair Enzymes - genetics Gene Knockout Techniques HCT116 Cells Humans Molecular Targeted Therapy Neoplasms - drug therapy Neoplasms - genetics Neoplasms - pathology Neoplasms - radiotherapy Phosphotransferases (Alcohol Group Acceptor) - antagonists & inhibitors Phosphotransferases (Alcohol Group Acceptor) - genetics PTEN Phosphohydrolase - genetics Radiation Tolerance - drug effects RNA, Small Interfering
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