Milatuzumab-Conjugated Liposomes as Targeted Dexamethasone Carriers for Therapeutic Delivery in CD74+ B-cell Malignancies

Corticosteroids are widely used for the treatment of B-cell malignancies, including non-Hodgkin lymphoma, chronic lymphocytic leukemia (CLL), and acute lymphoblastic leukemia; however, this class of drug is associated with undesirable off-target effects. Herein, we developed novel milatuzumab-conjug...

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Veröffentlicht in:	Clinical cancer research 2013-01, Vol.19 (2), p.347-356
Hauptverfasser:	YICHENG MAO, TRIANTAFILLOU, Georgia, GOLDENBERG, David M, LEE, Robert J, BYRD, John C, MUTHUSAMY, Natarajan, HERTLEIN, Erin, TOWNS, William, STEFANOVSKI, Matthew, XIAOKUI MO, JARJOURA, David, PHELPS, Mitch, MARCUCCI, Guido, JAMES LEE, Ly
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal, Humanized - administration & dosage Antibodies, Monoclonal, Humanized - pharmacology Antigens, Differentiation, B-Lymphocyte - metabolism Antineoplastic agents Biological and medical sciences Cell Line, Tumor Chemotherapy Dexamethasone - administration & dosage Dexamethasone - pharmacology Disease Models, Animal Female Histocompatibility Antigens Class II - metabolism Humans Leukemia, B-Cell - drug therapy Leukemia, B-Cell - metabolism Leukemia, B-Cell - mortality Liposomes Lymphoma, B-Cell - drug therapy Lymphoma, B-Cell - metabolism Lymphoma, B-Cell - mortality Medical sciences Mice Pharmacology. Drug treatments Tumor Burden - drug effects Xenograft Model Antitumor Assays
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