Sphingosine kinase 1 deficiency confers protection against hyperoxia-induced bronchopulmonary dysplasia in a murine model: role of S1P signaling and Nox proteins

Bronchopulmonary dysplasia of the premature newborn is characterized by lung injury, resulting in alveolar simplification and reduced pulmonary function. Exposure of neonatal mice to hyperoxia enhanced sphingosine-1-phosphate (S1P) levels in lung tissues; however, the role of increased S1P in the pa...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The American journal of pathology 2013-10, Vol.183 (4), p.1169-1182
Hauptverfasser:	Harijith, Anantha, Pendyala, Srikanth, Reddy, Narsa M, Bai, Tao, Usatyuk, Peter V, Berdyshev, Evgeny, Gorshkova, Irina, Huang, Long Shuang, Mohan, Vijay, Garzon, Steve, Kanteti, Prasad, Reddy, Sekhar P, Raj, J Usha, Natarajan, Viswanathan
Format:	Artikel
Sprache:	eng
Schlagworte:	Aldehyde-Lyases - deficiency Aldehyde-Lyases - metabolism Animals Animals, Newborn Bronchopulmonary Dysplasia - enzymology Bronchopulmonary Dysplasia - etiology Bronchopulmonary Dysplasia - pathology Bronchopulmonary Dysplasia - prevention & control Disease Models, Animal Down-Regulation - drug effects Endothelial Cells - drug effects Endothelial Cells - enzymology Endothelial Cells - pathology Humans Hyperoxia - complications Hyperoxia - enzymology Hyperoxia - pathology Lysophospholipids - metabolism Membrane Glycoproteins - metabolism Mice Mice, Inbred C57BL NADPH Oxidase 2 NADPH Oxidase 4 NADPH Oxidases - metabolism Phosphotransferases (Alcohol Group Acceptor) - deficiency Phosphotransferases (Alcohol Group Acceptor) - metabolism Pneumonia - complications Pneumonia - pathology Pulmonary Alveoli - enzymology Pulmonary Alveoli - pathology rac1 GTP-Binding Protein - metabolism Reactive Oxygen Species - metabolism Regular Signal Transduction Sphingosine - analogs & derivatives Sphingosine - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!