Deletion of the Olfactomedin 4 Gene Is Associated with Progression of Human Prostate Cancer

The olfactomedin 4 ( OLFM4 ) gene is located on chromosome 13q14.3, which frequently is deleted in human prostate cancer. However, direct genetic evidence of OLFM4 gene alteration in human prostate cancer has not yet been obtained. In this study, we investigated the genetics, protein expression, and...

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Veröffentlicht in:	The American journal of pathology 2013-10, Vol.183 (4), p.1329-1338
Hauptverfasser:	Li, Hongzhen, Rodriguez-Canales, Jaime, Liu, Wenli, Zhu, Jianqiong, Hanson, Jeffrey C, Pack, Svetlana, Zhuang, Zhengping, Emmert-Buck, Michael R, Rodgers, Griffin P
Format:	Artikel
Sprache:	eng
Schlagworte:	Autophagy - genetics Base Sequence Cathepsin D - metabolism Cell Line, Tumor Cell Proliferation Disease Progression Gene Deletion Gene Expression Regulation, Neoplastic Genome, Human - genetics Granulocyte Colony-Stimulating Factor - chemistry Granulocyte Colony-Stimulating Factor - genetics Granulocyte Colony-Stimulating Factor - metabolism Homozygote Humans In Situ Hybridization, Fluorescence Laser Capture Microdissection Male Molecular Sequence Data Mutant Proteins - metabolism Neoplasm Staging Pathology Polymorphism, Single Nucleotide - genetics Prostatic Neoplasms - enzymology Prostatic Neoplasms - genetics Prostatic Neoplasms - pathology Protein Structure, Tertiary Regular Tissue Array Analysis
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