Effect of a Monofunctional Phenanthriplatin-DNA Adduct on RNA Polymerase II Transcriptional Fidelity and Translesion Synthesis

Transcription inhibition by platinum anticancer drugs is an important component of their mechanism of action. Phen­anthri­platin, a cisplatin derivative containing phen­anthridine in place of one of the chloride ligands, forms highly potent monofunctional adducts on DNA having a structure and spectr...

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Veröffentlicht in:	Journal of the American Chemical Society 2013-09, Vol.135 (35), p.13054-13061
Hauptverfasser:	Kellinger, Matthew W, Park, Ga Young, Chong, Jenny, Lippard, Stephen J, Wang, Dong
Format:	Artikel
Sprache:	eng
Schlagworte:	DNA Adducts - chemistry DNA Adducts - drug effects DNA Adducts - metabolism DNA Damage Molecular Structure Organoplatinum Compounds - chemistry Organoplatinum Compounds - pharmacology Phenanthridines - chemistry Phenanthridines - pharmacology RNA Polymerase II - antagonists & inhibitors RNA Polymerase II - chemistry RNA Polymerase II - metabolism Structure-Activity Relationship Transcription, Genetic - drug effects
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