Abnormalities in the alternative pathway of complement in children with hematopoietic stem cell transplant-associated thrombotic microangiopathy

Hematopoietic stem cell transplant (HSCT)-associated thrombotic microangiopathy (TMA) is a complication that occurs in 25% to 35% of HSCT recipients and shares histomorphologic similarities with hemolytic uremic syndrome (HUS) and thrombotic thrombocytopenic purpura (TTP). The hallmark of all thromb...

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Veröffentlicht in:	Blood 2013-09, Vol.122 (12), p.2003-2007
Hauptverfasser:	Jodele, Sonata, Licht, Christoph, Goebel, Jens, Dixon, Bradley P., Zhang, Kejian, Sivakumaran, Theru A., Davies, Stella M., Pluthero, Fred G., Lu, Lily, Laskin, Benjamin L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Autoantibodies - immunology Child Child, Preschool Complement Pathway, Alternative Complement System Proteins - genetics Complement System Proteins - immunology Gene Deletion Genotype Hematopoietic Stem Cell Transplantation - adverse effects Humans Plenary Paper Thrombotic Microangiopathies - etiology
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