TNF-α Induces Phenotypic Modulation in Cerebral Vascular Smooth Muscle Cells: Implications for Cerebral Aneurysm Pathology

Little is known about vascular smooth muscle cell (SMC) phenotypic modulation in the cerebral circulation or pathogenesis of intracranial aneurysms. Tumor necrosis factor-alpha (TNF-α) has been associated with aneurysms, but potential mechanisms are unclear. Cultured rat cerebral SMCs overexpressing...

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Veröffentlicht in:	Journal of cerebral blood flow and metabolism 2013-10, Vol.33 (10), p.1564-1573
Hauptverfasser:	Ali, Muhammad S, Starke, Robert M, Jabbour, Pascal M, Tjoumakaris, Stavropoula I, Gonzalez, L Fernando, Rosenwasser, Robert H, Owens, Gary K, Koch, Walter J, Greig, Nigel H, Dumont, Aaron S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - drug effects Apoptosis - genetics Carotid Arteries - drug effects Carotid Arteries - pathology Cell Differentiation - drug effects Cell Differentiation - genetics Cells, Cultured Circle of Willis - drug effects Circle of Willis - metabolism Circle of Willis - pathology Disease Models, Animal Dose-Response Relationship, Drug Epigenesis, Genetic Genetic Markers - drug effects Intracranial Aneurysm - genetics Intracranial Aneurysm - immunology Intracranial Aneurysm - pathology Kruppel-Like Transcription Factors - genetics Kruppel-Like Transcription Factors - physiology Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - metabolism Muscle, Smooth, Vascular - pathology Nuclear Proteins - genetics Original Promoter Regions, Genetic Rats Thalidomide - analogs & derivatives Thalidomide - pharmacology Trans-Activators - genetics Transcriptome Tumor Necrosis Factor-alpha - antagonists & inhibitors Tumor Necrosis Factor-alpha - pharmacology Tumor Necrosis Factor-alpha - physiology
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