Merkel polyomavirus-specific T cells fluctuate with merkel cell carcinoma burden and express therapeutically targetable PD-1 and Tim-3 exhaustion markers

The persistent expression of Merkel cell polyomavirus (MCPyV) oncoproteins in Merkel cell carcinoma (MCC) provides a unique opportunity to characterize immune evasion mechanisms in human cancer. We isolated MCPyV-specific T cells and determined their frequency and functional status. Multiparameter f...

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Veröffentlicht in:	Clinical cancer research 2013-10, Vol.19 (19), p.5351-5360
Hauptverfasser:	Afanasiev, Olga K, Yelistratova, Lola, Miller, Natalie, Nagase, Kotaro, Paulson, Kelly, Iyer, Jayasri G, Ibrani, Dafina, Koelle, David M, Nghiem, Paul
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Viral - immunology Antigens, Viral - immunology Antigens, Viral - metabolism Biomarkers - metabolism Carcinoma, Merkel Cell - immunology Carcinoma, Merkel Cell - metabolism Carcinoma, Merkel Cell - pathology Carcinoma, Merkel Cell - virology Case-Control Studies CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - metabolism Hepatitis A Virus Cellular Receptor 2 Immunohistochemistry Immunophenotyping Lymphocytes, Tumor-Infiltrating - immunology Lymphocytes, Tumor-Infiltrating - metabolism Membrane Proteins - metabolism Merkel cell polyomavirus - immunology Oncogene Proteins, Viral - immunology Oncogene Proteins, Viral - metabolism Polyomavirus Programmed Cell Death 1 Receptor - metabolism T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - metabolism Tumor Burden - immunology
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