Heligmosomoides polygyrus bakeri infection activates colonic Foxp3+ T cells enhancing their capacity to prevent colitis

Helminthic infections protect mice from colitis in murine models of inflammatory bowel disease and also may protect people. Helminths like Heligmosomoides polygyrus bakeri can induce regulatory T cells (Treg). Experiments explored whether H. polygyrus bakeri infection could protect mice from colitis...

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Veröffentlicht in:	The Journal of immunology (1950) 2013-08, Vol.191 (4), p.1927-1934
Hauptverfasser:	Hang, Long, Blum, Arthur M, Setiawan, Tommy, Urban, Jr, Joseph P, Stoyanoff, Korynn M, Weinstock, Joel V
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Colitis - immunology Colitis - parasitology Colitis - prevention & control Colon - immunology Colon - parasitology Cytokines - biosynthesis Cytokines - secretion Disease Models, Animal DNA-Binding Proteins - deficiency Forkhead Transcription Factors - analysis Forkhead Transcription Factors - deficiency Genes, Reporter Graft Survival Helminthiasis, Animal - immunology Immunotherapy, Adoptive Inflammatory Bowel Diseases - therapy Interleukin-10 - analysis Intestinal Diseases, Parasitic - immunology Intestinal Mucosa - immunology Intestinal Mucosa - pathology Lymph Nodes - immunology Lymph Nodes - pathology Mesentery Mice Mice, Inbred C57BL Mice, Knockout Mice, Transgenic Nematospiroides dubius - immunology Specific Pathogen-Free Organisms Spleen - immunology Spleen - pathology Strongylida Infections - immunology T-Lymphocyte Subsets - chemistry T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - transplantation T-Lymphocytes, Regulatory - chemistry T-Lymphocytes, Regulatory - immunology T-Lymphocytes, Regulatory - transplantation Therapy with Helminths
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