STAT3 mutations indicate the presence of subclinical T-cell clones in a subset of aplastic anemia and myelodysplastic syndrome patients

Large granular lymphocyte leukemia (LGL) is often associated with immune cytopenias and can cooccur in the context of aplastic anemia (AA) and myelodysplastic syndromes (MDS). We took advantage of the recent description of signal transducer and activator of transcription 3 (STAT3) mutations in LGL c...

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Veröffentlicht in:	Blood 2013-10, Vol.122 (14), p.2453-2459
Hauptverfasser:	Jerez, Andres, Clemente, Michael J., Makishima, Hideki, Rajala, Hanna, Gómez-Seguí, Ines, Olson, Thomas, McGraw, Kathy, Przychodzen, Bartlomiej, Kulasekararaj, Austin, Afable, Manuel, Husseinzadeh, Holleh D., Hosono, Naoko, LeBlanc, Francis, Lagström, Sonja, Zhang, Dan, Ellonen, Pekka, Tichelli, André, Nissen, Catherine, Lichtin, Alan E., Wodnar-Filipowicz, Aleksandra, Mufti, Ghulam J., List, Alan F., Mustjoki, Satu, Loughran, Thomas P., Maciejewski, Jaroslaw P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Anemia, Aplastic - complications Anemia, Aplastic - genetics Anemia, Aplastic - mortality Cell Separation Female Flow Cytometry Humans Kaplan-Meier Estimate Leukemia, Large Granular Lymphocytic - complications Leukemia, Large Granular Lymphocytic - genetics Leukemia, Large Granular Lymphocytic - mortality Male Middle Aged Mutation Myelodysplastic Syndromes - complications Myelodysplastic Syndromes - genetics Myelodysplastic Syndromes - mortality Myeloid Neoplasia Proportional Hazards Models Reverse Transcriptase Polymerase Chain Reaction STAT3 Transcription Factor - genetics
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