Angiopoietin-like protein 4 inhibition of lipoprotein lipase: evidence for reversible complex formation

Elevated triglycerides are associated with an increased risk of cardiovascular disease, and lipoprotein lipase (LPL) is the rate-limiting enzyme for the hydrolysis of triglycerides from circulating lipoproteins. The N-terminal domain of angiopoietin-like protein 4 (ANGPTL4) inhibits LPL activity. AN...

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Veröffentlicht in:	The Journal of biological chemistry 2013-10, Vol.288 (40), p.28524-28534
Hauptverfasser:	Lafferty, Michael J, Bradford, Kira C, Erie, Dorothy A, Neher, Saskia B
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiopoietins - isolation & purification Angiopoietins - metabolism Animals Biocatalysis Cattle Chromatography, Affinity Cross-Linking Reagents Enzyme Activation Heparin Hot Temperature Lipids Lipoprotein Lipase - antagonists & inhibitors Lipoprotein Lipase - isolation & purification Lipoprotein Lipase - metabolism Microscopy, Atomic Force Models, Biological Multiprotein Complexes - metabolism Sepharose Time Factors
Online-Zugang:	Volltext
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