Cystic Echinococcosis in a Single Tertiary Care Center in Rome, Italy
Background. Cystic echinococcosis (CE) is a chronic, clinically complex, and neglected disease. Its prevalence in Italy, a country of medium to high endemicity, remains poorly defined, as notification has long ceased to be mandatory. Methods. We set up a retrospective cohort study involving all CE p...
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| Veröffentlicht in: | BioMed research international 2013-01, Vol.2013 (2013), p.1-9 |
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| creator | Pane, Stefania Di Caro, Antonino Girardi, Enrico Pozio, Edoardo Corpolongo, Angela Teggi, Antonella Brunetti, Enrico Goletti, Delia Angeletti, Claudio Pucillo, Leopoldo Schininà, Vincenzo Busi-Rizzi, Elisa Ettorre, Giuseppe Maria Colace, Lidia Cuzzi, Gilda Petrone, Linda Bordi, Eugenio |
| description | Background. Cystic echinococcosis (CE) is a chronic, clinically complex, and neglected disease. Its prevalence in Italy, a country of medium to high endemicity, remains poorly defined, as notification has long ceased to be mandatory. Methods. We set up a retrospective cohort study involving all CE patients followed at our institute between January 2005 and December 2012. Demographical and clinical features were recorded and analyzed. Results. CE was found in 28 patients (64.3%), mostly Italians from the central regions (50%), followed by subjects from the islands (33.3%) and Southern Italy (16.7%). Their median age was 45 years (IQR: 38.5–66.5), with Eastern Europeans being significantly younger (28 years, IQR: 19–39) than other patients (P≤0.0001). A total of 149 cysts, mostly with hepatic localization (96%), were described. Based on the WHO classification, the cysts were mainly small (80.5%) and active (CE1 (73.8%); CE2 (7.4%)). Active cysts were more common in Eastern Europeans (85.7%) than Italians (66.7%). Conclusion. Our data confirm CE occurrence in Italy. We emphasize the importance to have a national CE registry, opportunely recently introduced. This is essential to assess CE prevalence in this country, implement appropriate control measures, and improve patient management. |
| doi_str_mv | 10.1155/2013/978146 |
| format | Article |
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Cystic echinococcosis (CE) is a chronic, clinically complex, and neglected disease. Its prevalence in Italy, a country of medium to high endemicity, remains poorly defined, as notification has long ceased to be mandatory. Methods. We set up a retrospective cohort study involving all CE patients followed at our institute between January 2005 and December 2012. Demographical and clinical features were recorded and analyzed. Results. CE was found in 28 patients (64.3%), mostly Italians from the central regions (50%), followed by subjects from the islands (33.3%) and Southern Italy (16.7%). Their median age was 45 years (IQR: 38.5–66.5), with Eastern Europeans being significantly younger (28 years, IQR: 19–39) than other patients (P≤0.0001). A total of 149 cysts, mostly with hepatic localization (96%), were described. Based on the WHO classification, the cysts were mainly small (80.5%) and active (CE1 (73.8%); CE2 (7.4%)). Active cysts were more common in Eastern Europeans (85.7%) than Italians (66.7%). Conclusion. Our data confirm CE occurrence in Italy. We emphasize the importance to have a national CE registry, opportunely recently introduced. This is essential to assess CE prevalence in this country, implement appropriate control measures, and improve patient management.</description><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2013/978146</identifier><identifier>PMID: 24151631</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Adult ; Age ; Animals ; Antigens ; Clinical Study ; Cysts ; Cysts - pathology ; Echinococcosis - epidemiology ; Echinococcosis - therapy ; Echinococcus ; Echinococcus - pathogenicity ; Epidemiology ; HIV ; Human immunodeficiency virus ; Humans ; Immunology ; Infectious diseases ; Italy ; Laboratories ; Liver - parasitology ; Liver - pathology ; Male ; Middle Aged ; Serology ; Tertiary Care Centers ; Tuberculosis ; Ultrasonic imaging</subject><ispartof>BioMed research international, 2013-01, Vol.2013 (2013), p.1-9</ispartof><rights>Copyright © 2013 Linda Petrone et al.</rights><rights>Copyright © 2013 Linda Petrone et al. Linda Petrone et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2013 Linda Petrone et al. 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c500t-e1c30a6116ad1f56a38122fd1187b0f978f0e8f14d06ea7e21874e17c79ba1063</citedby><cites>FETCH-LOGICAL-c500t-e1c30a6116ad1f56a38122fd1187b0f978f0e8f14d06ea7e21874e17c79ba1063</cites><orcidid>0000-0002-6386-0855 ; 0000-0001-8182-5896 ; 0000-0003-0158-2535 ; 0000-0002-2593-3478 ; 0000-0001-8360-4376 ; 0000-0001-6027-3009</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3789360/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3789360/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24151631$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Bouakaz, Ayache</contributor><creatorcontrib>Pane, Stefania</creatorcontrib><creatorcontrib>Di Caro, Antonino</creatorcontrib><creatorcontrib>Girardi, Enrico</creatorcontrib><creatorcontrib>Pozio, Edoardo</creatorcontrib><creatorcontrib>Corpolongo, Angela</creatorcontrib><creatorcontrib>Teggi, Antonella</creatorcontrib><creatorcontrib>Brunetti, Enrico</creatorcontrib><creatorcontrib>Goletti, Delia</creatorcontrib><creatorcontrib>Angeletti, Claudio</creatorcontrib><creatorcontrib>Pucillo, Leopoldo</creatorcontrib><creatorcontrib>Schininà, Vincenzo</creatorcontrib><creatorcontrib>Busi-Rizzi, Elisa</creatorcontrib><creatorcontrib>Ettorre, Giuseppe Maria</creatorcontrib><creatorcontrib>Colace, Lidia</creatorcontrib><creatorcontrib>Cuzzi, Gilda</creatorcontrib><creatorcontrib>Petrone, Linda</creatorcontrib><creatorcontrib>Bordi, Eugenio</creatorcontrib><title>Cystic Echinococcosis in a Single Tertiary Care Center in Rome, Italy</title><title>BioMed research international</title><addtitle>Biomed Res Int</addtitle><description>Background. Cystic echinococcosis (CE) is a chronic, clinically complex, and neglected disease. Its prevalence in Italy, a country of medium to high endemicity, remains poorly defined, as notification has long ceased to be mandatory. Methods. We set up a retrospective cohort study involving all CE patients followed at our institute between January 2005 and December 2012. Demographical and clinical features were recorded and analyzed. Results. CE was found in 28 patients (64.3%), mostly Italians from the central regions (50%), followed by subjects from the islands (33.3%) and Southern Italy (16.7%). Their median age was 45 years (IQR: 38.5–66.5), with Eastern Europeans being significantly younger (28 years, IQR: 19–39) than other patients (P≤0.0001). A total of 149 cysts, mostly with hepatic localization (96%), were described. Based on the WHO classification, the cysts were mainly small (80.5%) and active (CE1 (73.8%); CE2 (7.4%)). Active cysts were more common in Eastern Europeans (85.7%) than Italians (66.7%). Conclusion. Our data confirm CE occurrence in Italy. We emphasize the importance to have a national CE registry, opportunely recently introduced. This is essential to assess CE prevalence in this country, implement appropriate control measures, and improve patient management.</description><subject>Adult</subject><subject>Age</subject><subject>Animals</subject><subject>Antigens</subject><subject>Clinical Study</subject><subject>Cysts</subject><subject>Cysts - pathology</subject><subject>Echinococcosis - epidemiology</subject><subject>Echinococcosis - therapy</subject><subject>Echinococcus</subject><subject>Echinococcus - pathogenicity</subject><subject>Epidemiology</subject><subject>HIV</subject><subject>Human immunodeficiency virus</subject><subject>Humans</subject><subject>Immunology</subject><subject>Infectious diseases</subject><subject>Italy</subject><subject>Laboratories</subject><subject>Liver - parasitology</subject><subject>Liver - pathology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Serology</subject><subject>Tertiary Care Centers</subject><subject>Tuberculosis</subject><subject>Ultrasonic imaging</subject><issn>2314-6133</issn><issn>2314-6141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqNkc9LHDEYhkOpVFFPvcuAl2JdzTf5ORdBhm0VFgqtPYds5hvNMjvRZFbZ_75Zdl1WLzaXhOTh5f3yEPIV6AWAEJclBXZZKQ1cfiIHJQM-ksDh8_bM2D45TmlG89IgaSW_kP2SgwDJ4ICM62UavCvG7sH3wQXnQvKp8H1hiz--v--wuMM4eBuXRW0jFjX2A8YV8DvM8by4HWy3PCJ7re0SHm_2Q_L3x_iuvhlNfv28ra8nIycoHUYIjlErAaRtoBXSMg1l2TYAWk1pm8doKeoWeEMlWoVlvucIyqlqaoFKdkiu1rmPi-kcG5e7RNuZx-jnuaAJ1pu3L71_MPfh2TClKyZpDvi2CYjhaYFpMHOfHHad7TEskgFBtRJaKfUxyjnXQmpRZvT0HToLi9jnn1hRrJSV0CxT39eUiyGliO22N1CzkmlWMs1aZqZPdkfdsq_qMnC2BrK4xr74_0vDjGBrd2CWdXD2D8ejrXw</recordid><startdate>20130101</startdate><enddate>20130101</enddate><creator>Pane, Stefania</creator><creator>Di Caro, Antonino</creator><creator>Girardi, Enrico</creator><creator>Pozio, Edoardo</creator><creator>Corpolongo, Angela</creator><creator>Teggi, Antonella</creator><creator>Brunetti, Enrico</creator><creator>Goletti, Delia</creator><creator>Angeletti, Claudio</creator><creator>Pucillo, Leopoldo</creator><creator>Schininà, Vincenzo</creator><creator>Busi-Rizzi, Elisa</creator><creator>Ettorre, Giuseppe Maria</creator><creator>Colace, Lidia</creator><creator>Cuzzi, Gilda</creator><creator>Petrone, Linda</creator><creator>Bordi, Eugenio</creator><general>Hindawi Publishing Corporation</general><general>Hindawi Limited</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QO</scope><scope>7T7</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>CWDGH</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-6386-0855</orcidid><orcidid>https://orcid.org/0000-0001-8182-5896</orcidid><orcidid>https://orcid.org/0000-0003-0158-2535</orcidid><orcidid>https://orcid.org/0000-0002-2593-3478</orcidid><orcidid>https://orcid.org/0000-0001-8360-4376</orcidid><orcidid>https://orcid.org/0000-0001-6027-3009</orcidid></search><sort><creationdate>20130101</creationdate><title>Cystic Echinococcosis in a Single Tertiary Care Center in Rome, Italy</title><author>Pane, Stefania ; Di Caro, Antonino ; Girardi, Enrico ; Pozio, Edoardo ; Corpolongo, Angela ; Teggi, Antonella ; Brunetti, Enrico ; Goletti, Delia ; Angeletti, Claudio ; Pucillo, Leopoldo ; Schininà, Vincenzo ; Busi-Rizzi, Elisa ; Ettorre, Giuseppe Maria ; Colace, Lidia ; Cuzzi, Gilda ; Petrone, Linda ; Bordi, Eugenio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c500t-e1c30a6116ad1f56a38122fd1187b0f978f0e8f14d06ea7e21874e17c79ba1063</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Age</topic><topic>Animals</topic><topic>Antigens</topic><topic>Clinical Study</topic><topic>Cysts</topic><topic>Cysts - pathology</topic><topic>Echinococcosis - epidemiology</topic><topic>Echinococcosis - therapy</topic><topic>Echinococcus</topic><topic>Echinococcus - pathogenicity</topic><topic>Epidemiology</topic><topic>HIV</topic><topic>Human immunodeficiency virus</topic><topic>Humans</topic><topic>Immunology</topic><topic>Infectious diseases</topic><topic>Italy</topic><topic>Laboratories</topic><topic>Liver - parasitology</topic><topic>Liver - pathology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Serology</topic><topic>Tertiary Care Centers</topic><topic>Tuberculosis</topic><topic>Ultrasonic imaging</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pane, Stefania</creatorcontrib><creatorcontrib>Di Caro, Antonino</creatorcontrib><creatorcontrib>Girardi, Enrico</creatorcontrib><creatorcontrib>Pozio, Edoardo</creatorcontrib><creatorcontrib>Corpolongo, Angela</creatorcontrib><creatorcontrib>Teggi, Antonella</creatorcontrib><creatorcontrib>Brunetti, Enrico</creatorcontrib><creatorcontrib>Goletti, Delia</creatorcontrib><creatorcontrib>Angeletti, Claudio</creatorcontrib><creatorcontrib>Pucillo, Leopoldo</creatorcontrib><creatorcontrib>Schininà, Vincenzo</creatorcontrib><creatorcontrib>Busi-Rizzi, Elisa</creatorcontrib><creatorcontrib>Ettorre, Giuseppe Maria</creatorcontrib><creatorcontrib>Colace, Lidia</creatorcontrib><creatorcontrib>Cuzzi, Gilda</creatorcontrib><creatorcontrib>Petrone, Linda</creatorcontrib><creatorcontrib>Bordi, Eugenio</creatorcontrib><collection>الدوريات العلمية والإحصائية - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BioMed research international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pane, Stefania</au><au>Di Caro, Antonino</au><au>Girardi, Enrico</au><au>Pozio, Edoardo</au><au>Corpolongo, Angela</au><au>Teggi, Antonella</au><au>Brunetti, Enrico</au><au>Goletti, Delia</au><au>Angeletti, Claudio</au><au>Pucillo, Leopoldo</au><au>Schininà, Vincenzo</au><au>Busi-Rizzi, Elisa</au><au>Ettorre, Giuseppe Maria</au><au>Colace, Lidia</au><au>Cuzzi, Gilda</au><au>Petrone, Linda</au><au>Bordi, Eugenio</au><au>Bouakaz, Ayache</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cystic Echinococcosis in a Single Tertiary Care Center in Rome, Italy</atitle><jtitle>BioMed research international</jtitle><addtitle>Biomed Res Int</addtitle><date>2013-01-01</date><risdate>2013</risdate><volume>2013</volume><issue>2013</issue><spage>1</spage><epage>9</epage><pages>1-9</pages><issn>2314-6133</issn><eissn>2314-6141</eissn><abstract>Background. Cystic echinococcosis (CE) is a chronic, clinically complex, and neglected disease. Its prevalence in Italy, a country of medium to high endemicity, remains poorly defined, as notification has long ceased to be mandatory. Methods. We set up a retrospective cohort study involving all CE patients followed at our institute between January 2005 and December 2012. Demographical and clinical features were recorded and analyzed. Results. CE was found in 28 patients (64.3%), mostly Italians from the central regions (50%), followed by subjects from the islands (33.3%) and Southern Italy (16.7%). Their median age was 45 years (IQR: 38.5–66.5), with Eastern Europeans being significantly younger (28 years, IQR: 19–39) than other patients (P≤0.0001). A total of 149 cysts, mostly with hepatic localization (96%), were described. Based on the WHO classification, the cysts were mainly small (80.5%) and active (CE1 (73.8%); CE2 (7.4%)). Active cysts were more common in Eastern Europeans (85.7%) than Italians (66.7%). Conclusion. Our data confirm CE occurrence in Italy. We emphasize the importance to have a national CE registry, opportunely recently introduced. This is essential to assess CE prevalence in this country, implement appropriate control measures, and improve patient management.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>24151631</pmid><doi>10.1155/2013/978146</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-6386-0855</orcidid><orcidid>https://orcid.org/0000-0001-8182-5896</orcidid><orcidid>https://orcid.org/0000-0003-0158-2535</orcidid><orcidid>https://orcid.org/0000-0002-2593-3478</orcidid><orcidid>https://orcid.org/0000-0001-8360-4376</orcidid><orcidid>https://orcid.org/0000-0001-6027-3009</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Age Animals Antigens Clinical Study Cysts Cysts - pathology Echinococcosis - epidemiology Echinococcosis - therapy Echinococcus Echinococcus - pathogenicity Epidemiology HIV Human immunodeficiency virus Humans Immunology Infectious diseases Italy Laboratories Liver - parasitology Liver - pathology Male Middle Aged Serology Tertiary Care Centers Tuberculosis Ultrasonic imaging |
| title | Cystic Echinococcosis in a Single Tertiary Care Center in Rome, Italy |
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