Differential expression of filamin A and its clinical significance in breast cancer
Changes in filamin A (FLNa) expression contribute to the development and progression of numerous malignancies. However, in vitro studies of breast cancer have shown conflicting results. Thus, the present study aimed to detect the expression of FLNa in breast cancer tissue samples and the association...
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| Veröffentlicht in: | Oncology letters 2013-09, Vol.6 (3), p.681-686 |
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| creator | TIAN, HUI-MIN LIU, XIU-HUA HAN, WEI ZHAO, LING-LING YUAN, BO YUAN, CHANG-JI |
| description | Changes in filamin A (FLNa) expression contribute to the development and progression of numerous malignancies. However, in vitro studies of breast cancer have shown conflicting results. Thus, the present study aimed to detect the expression of FLNa in breast cancer tissue samples and the association with clinicopathological data, in order to provide insightful ex vivo data. A total of 96 breast cancer and distant normal breast tissues and 20 benign tumor tissue specimens were subjected to immunohistochemistry or reverse transcription polymerase chain reaction (RT-PCR) analysis of FLNa expression. Clinicopathological data were collected to analyze the association with FLNa expression. The FLNa protein was overexpressed in breast cancer tissues compared with distant normal mammary gland and benign breast tissues. The FLNa protein was expressed in 63.5% of breast cancer, with positive rates of 36, 66.7 and 84.6%, respectively, in stage I, II and III breast cancer patients (P |
| doi_str_mv | 10.3892/ol.2013.1454 |
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However, in vitro studies of breast cancer have shown conflicting results. Thus, the present study aimed to detect the expression of FLNa in breast cancer tissue samples and the association with clinicopathological data, in order to provide insightful ex vivo data. A total of 96 breast cancer and distant normal breast tissues and 20 benign tumor tissue specimens were subjected to immunohistochemistry or reverse transcription polymerase chain reaction (RT-PCR) analysis of FLNa expression. Clinicopathological data were collected to analyze the association with FLNa expression. The FLNa protein was overexpressed in breast cancer tissues compared with distant normal mammary gland and benign breast tissues. The FLNa protein was expressed in 63.5% of breast cancer, with positive rates of 36, 66.7 and 84.6%, respectively, in stage I, II and III breast cancer patients (P<0.05). Overexpression of the FLNa protein was associated with advanced stage, lymph node metastasis, vascular or neural invasion, menstruation state and other risk stratifications for breast cancer. The overexpression of FLNa in breast cancer was validated by RT-PCR, indicating transcriptional regulation of FLNa overexpression in breast cancer. FLNa mRNA and protein were overexpressed in breast cancer tissues, which was associated with advanced stage, lymph node metastasis and vascular or neural invasion of breast cancer, suggesting that FLNa contributes to breast cancer development and progression.</description><identifier>ISSN: 1792-1074</identifier><identifier>EISSN: 1792-1082</identifier><identifier>DOI: 10.3892/ol.2013.1454</identifier><identifier>PMID: 24137390</identifier><language>eng</language><publisher>Greece: D.A. Spandidos</publisher><subject>Biomarkers ; Breast cancer ; Cell adhesion & migration ; Cell division ; Clinical significance ; filamin A ; immunohistochemistry ; Lung cancer ; Melanoma ; Metastasis ; Oncology ; Patients ; Protein expression ; Proteins ; reverse transcription-polymerase chain reaction ; Signal transduction ; Studies</subject><ispartof>Oncology letters, 2013-09, Vol.6 (3), p.681-686</ispartof><rights>Copyright © 2013, Spandidos Publications</rights><rights>Copyright Spandidos Publications UK Ltd. 2013</rights><rights>Copyright © 2013, Spandidos Publications 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c509t-8aa799c5496d8175adf8489973d6f72cdb1847dc46ddf1077789ae8255076a0e3</citedby><cites>FETCH-LOGICAL-c509t-8aa799c5496d8175adf8489973d6f72cdb1847dc46ddf1077789ae8255076a0e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3789035/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3789035/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,5569,27922,27923,53789,53791</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24137390$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>TIAN, HUI-MIN</creatorcontrib><creatorcontrib>LIU, XIU-HUA</creatorcontrib><creatorcontrib>HAN, WEI</creatorcontrib><creatorcontrib>ZHAO, LING-LING</creatorcontrib><creatorcontrib>YUAN, BO</creatorcontrib><creatorcontrib>YUAN, CHANG-JI</creatorcontrib><title>Differential expression of filamin A and its clinical significance in breast cancer</title><title>Oncology letters</title><addtitle>Oncol Lett</addtitle><description>Changes in filamin A (FLNa) expression contribute to the development and progression of numerous malignancies. However, in vitro studies of breast cancer have shown conflicting results. Thus, the present study aimed to detect the expression of FLNa in breast cancer tissue samples and the association with clinicopathological data, in order to provide insightful ex vivo data. A total of 96 breast cancer and distant normal breast tissues and 20 benign tumor tissue specimens were subjected to immunohistochemistry or reverse transcription polymerase chain reaction (RT-PCR) analysis of FLNa expression. Clinicopathological data were collected to analyze the association with FLNa expression. The FLNa protein was overexpressed in breast cancer tissues compared with distant normal mammary gland and benign breast tissues. The FLNa protein was expressed in 63.5% of breast cancer, with positive rates of 36, 66.7 and 84.6%, respectively, in stage I, II and III breast cancer patients (P<0.05). Overexpression of the FLNa protein was associated with advanced stage, lymph node metastasis, vascular or neural invasion, menstruation state and other risk stratifications for breast cancer. The overexpression of FLNa in breast cancer was validated by RT-PCR, indicating transcriptional regulation of FLNa overexpression in breast cancer. FLNa mRNA and protein were overexpressed in breast cancer tissues, which was associated with advanced stage, lymph node metastasis and vascular or neural invasion of breast cancer, suggesting that FLNa contributes to breast cancer development and progression.</description><subject>Biomarkers</subject><subject>Breast cancer</subject><subject>Cell adhesion & migration</subject><subject>Cell division</subject><subject>Clinical significance</subject><subject>filamin A</subject><subject>immunohistochemistry</subject><subject>Lung cancer</subject><subject>Melanoma</subject><subject>Metastasis</subject><subject>Oncology</subject><subject>Patients</subject><subject>Protein expression</subject><subject>Proteins</subject><subject>reverse transcription-polymerase chain reaction</subject><subject>Signal transduction</subject><subject>Studies</subject><issn>1792-1074</issn><issn>1792-1082</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpdkctrlDEUxYNYbGm7cy0BQVz4jXk_NkKp2hYKLtR1yORRUzLJmHwj7X9vxmlHbRY395IfJzk5ALzEaEGVJu9rXhCE6QIzzp6BIyw1mTBS5Pm-l-wQnPZ-i8biAislXoBDwjCVVKMj8PVjijG0UOZkMwx36xZ6T7XAGmFM2a5SgWfQFg_T3KHLqSQ3wJ5uSoqjLS7AgSxbsH2Gf-Z2Ag6izT2cPuzH4PvnT9_OL6frLxdX52fXk-NIz5OyVmrtONPCKyy59VExpbWkXkRJnF9ixaR3THgfhxEplbZBEc6RFBYFegw-7HTXm-UqeDdMNJvNuqWVbfem2mT-Pynph7mpvwwdSojyIfD2QaDVn5vQZ7NK3YWcbQl10w1WRHDJxoUDff0Eva2bVoY9gzUlgmx_fVDvdpRrtfcW4v4xGJltYKZmsw3MbAMb-Kt_Dezhx3gG8GYH9PWIIPna_7rLExIToqMqTH8DWAadFw</recordid><startdate>20130901</startdate><enddate>20130901</enddate><creator>TIAN, HUI-MIN</creator><creator>LIU, XIU-HUA</creator><creator>HAN, WEI</creator><creator>ZHAO, LING-LING</creator><creator>YUAN, BO</creator><creator>YUAN, CHANG-JI</creator><general>D.A. Spandidos</general><general>Spandidos Publications UK Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20130901</creationdate><title>Differential expression of filamin A and its clinical significance in breast cancer</title><author>TIAN, HUI-MIN ; LIU, XIU-HUA ; HAN, WEI ; ZHAO, LING-LING ; YUAN, BO ; YUAN, CHANG-JI</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c509t-8aa799c5496d8175adf8489973d6f72cdb1847dc46ddf1077789ae8255076a0e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Biomarkers</topic><topic>Breast cancer</topic><topic>Cell adhesion & migration</topic><topic>Cell division</topic><topic>Clinical significance</topic><topic>filamin A</topic><topic>immunohistochemistry</topic><topic>Lung cancer</topic><topic>Melanoma</topic><topic>Metastasis</topic><topic>Oncology</topic><topic>Patients</topic><topic>Protein expression</topic><topic>Proteins</topic><topic>reverse transcription-polymerase chain reaction</topic><topic>Signal transduction</topic><topic>Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>TIAN, HUI-MIN</creatorcontrib><creatorcontrib>LIU, XIU-HUA</creatorcontrib><creatorcontrib>HAN, WEI</creatorcontrib><creatorcontrib>ZHAO, LING-LING</creatorcontrib><creatorcontrib>YUAN, BO</creatorcontrib><creatorcontrib>YUAN, CHANG-JI</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Oncology letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>TIAN, HUI-MIN</au><au>LIU, XIU-HUA</au><au>HAN, WEI</au><au>ZHAO, LING-LING</au><au>YUAN, BO</au><au>YUAN, CHANG-JI</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Differential expression of filamin A and its clinical significance in breast cancer</atitle><jtitle>Oncology letters</jtitle><addtitle>Oncol Lett</addtitle><date>2013-09-01</date><risdate>2013</risdate><volume>6</volume><issue>3</issue><spage>681</spage><epage>686</epage><pages>681-686</pages><issn>1792-1074</issn><eissn>1792-1082</eissn><abstract>Changes in filamin A (FLNa) expression contribute to the development and progression of numerous malignancies. However, in vitro studies of breast cancer have shown conflicting results. Thus, the present study aimed to detect the expression of FLNa in breast cancer tissue samples and the association with clinicopathological data, in order to provide insightful ex vivo data. A total of 96 breast cancer and distant normal breast tissues and 20 benign tumor tissue specimens were subjected to immunohistochemistry or reverse transcription polymerase chain reaction (RT-PCR) analysis of FLNa expression. Clinicopathological data were collected to analyze the association with FLNa expression. The FLNa protein was overexpressed in breast cancer tissues compared with distant normal mammary gland and benign breast tissues. The FLNa protein was expressed in 63.5% of breast cancer, with positive rates of 36, 66.7 and 84.6%, respectively, in stage I, II and III breast cancer patients (P<0.05). Overexpression of the FLNa protein was associated with advanced stage, lymph node metastasis, vascular or neural invasion, menstruation state and other risk stratifications for breast cancer. The overexpression of FLNa in breast cancer was validated by RT-PCR, indicating transcriptional regulation of FLNa overexpression in breast cancer. FLNa mRNA and protein were overexpressed in breast cancer tissues, which was associated with advanced stage, lymph node metastasis and vascular or neural invasion of breast cancer, suggesting that FLNa contributes to breast cancer development and progression.</abstract><cop>Greece</cop><pub>D.A. Spandidos</pub><pmid>24137390</pmid><doi>10.3892/ol.2013.1454</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | Spandidos Publications Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Biomarkers Breast cancer Cell adhesion & migration Cell division Clinical significance filamin A immunohistochemistry Lung cancer Melanoma Metastasis Oncology Patients Protein expression Proteins reverse transcription-polymerase chain reaction Signal transduction Studies |
| title | Differential expression of filamin A and its clinical significance in breast cancer |
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