RhoA-Rho kinase and platelet-activating factor stimulation of ovine foetal pulmonary vascular smooth muscle cell proliferation

Objectives Platelet‐activating factor (PAF) is produced by pulmonary vascular smooth muscle cells (PVSMC). We studied effects of Rho kinase on PAF stimulation of PVSMC proliferation in an attempt to understand the role of RhoA/Rho kinase on PAF‐induced ovine foetal pulmonary vascular remodelling. Ou...

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Veröffentlicht in:	Cell proliferation 2013-10, Vol.46 (5), p.563-575
Hauptverfasser:	Renteria, L. S., Austin, M., Lazaro, M., Andrews, M. A., Lustina, J., Raj, J. U., Ibe, B. O.
Format:	Artikel
Sprache:	eng
Schlagworte:	1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - analogs & derivatives 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - pharmacology Amides - pharmacology Animals Cell Hypoxia Cell Proliferation - drug effects Cells, Cultured Flavonoids - pharmacology Imidazoles - pharmacology Lung - cytology Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors Mitogen-Activated Protein Kinase Kinases - metabolism Muscle, Smooth, Vascular - cytology Muscle, Smooth, Vascular - metabolism Mutation Original Platelet Activating Factor - pharmacology Platelet Membrane Glycoproteins - metabolism Pyridines - pharmacology Receptors, G-Protein-Coupled - metabolism rho-Associated Kinases - antagonists & inhibitors rho-Associated Kinases - metabolism rhoA GTP-Binding Protein - antagonists & inhibitors rhoA GTP-Binding Protein - genetics rhoA GTP-Binding Protein - metabolism Sheep
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