Metabotropic glutamate receptors: From the workbench to the bedside

Metabotropic glutamate (mGlu) receptors were discovered in the mid 1980s and originally described as glutamate receptors coupled to polyphosphoinositide hydrolysis. Almost 6500 articles have been published since then, and subtype-selective mGlu receptor ligands are now under clinical development for...

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Veröffentlicht in:	Neuropharmacology 2011-06, Vol.60 (7), p.1017-1041
Hauptverfasser:	Nicoletti, F., Bockaert, J., Collingridge, G.L., Conn, P.J., Ferraguti, F., Schoepp, D.D., Wroblewski, J.T., Pin, J.P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Clinical studies Humans Metabotropic glutamate receptors mGlu receptor ligands Parkinson Disease - drug therapy Parkinson Disease - metabolism Parkinson Disease - physiopathology Receptor structure Receptors, Metabotropic Glutamate - chemistry Receptors, Metabotropic Glutamate - drug effects Receptors, Metabotropic Glutamate - physiology Schizophrenia - drug therapy Schizophrenia - metabolism Schizophrenia - physiopathology Substance-Related Disorders - drug therapy Substance-Related Disorders - metabolism Substance-Related Disorders - physiopathology Translational Research, Biomedical
Online-Zugang:	Volltext
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