A co-clinical approach identifies mechanisms and potential therapies for androgen deprivation resistance in prostate cancer

Pier Paolo Pandolfi and colleagues report that compound loss of Pten with Zbtb7a or Trp53 leads to de novo resistance to androgen deprivation therapy in prostate cancer. Integrative analysis of mouse and human data in a co-clinical approach identified XIAP and SRD5A1 inhibitors as potential therapie...

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Veröffentlicht in:	Nature genetics 2013-07, Vol.45 (7), p.747-755
Hauptverfasser:	Lunardi, Andrea, Ala, Ugo, Epping, Mirjam T, Salmena, Leonardo, Clohessy, John G, Webster, Kaitlyn A, Wang, Guocan, Mazzucchelli, Roberta, Bianconi, Maristella, Stack, Edward C, Lis, Rosina, Patnaik, Akash, Cantley, Lewis C, Bubley, Glenn, Cordon-Cardo, Carlos, Gerald, William L, Montironi, Rodolfo, Signoretti, Sabina, Loda, Massimo, Nardella, Caterina, Pandolfi, Pier Paolo
Format:	Artikel
Sprache:	eng
Schlagworte:	631/208/2489 Agriculture Androgen Antagonists - therapeutic use Androgen suppression therapy Androgens Androgens - metabolism Animal Genetics and Genomics Animals Antineoplastic Agents - therapeutic use Apoptosis Biomarkers Biomedicine Cancer Research Cancer therapies Cancer treatment Care and treatment Cell Line, Tumor Development and progression Drug Evaluation, Preclinical Gene Function Genetic aspects Health aspects Human Genetics Humans Hypotheses Integrated approach Male Medical research Medical schools Mice Mice, Transgenic Models, Biological NMR Nuclear magnetic resonance Orchiectomy Pathology Phenylthiohydantoin - analogs & derivatives Phenylthiohydantoin - therapeutic use Prostate cancer Prostatic Neoplasms - genetics Prostatic Neoplasms - pathology Prostatic Neoplasms - therapy PTEN Phosphohydrolase - genetics Rodents Signal Transduction - drug effects Signal Transduction - genetics Therapies, Investigational Translational Medical Research - methods Treatment Failure Tumors
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