Tuning voltage-gated channel activity and cellular excitability with a sphingomyelinase

Voltage-gated ion channels generate action potentials in excitable cells and help set the resting membrane potential in nonexcitable cells like lymphocytes. It has been difficult to investigate what kinds of phospholipids interact with these membrane proteins in their native environments and what fu...

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Veröffentlicht in:	The Journal of general physiology 2013-10, Vol.142 (4), p.367-380
Hauptverfasser:	Combs, David J, Shin, Hyeon-Gyu, Xu, Yanping, Ramu, Yajamana, Lu, Zhe
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials Animals Calcium Channels - metabolism Cell Membrane - drug effects Cell Membrane - metabolism Cells CHO Cells Cricetinae Cricetulus Humans Jurkat Cells Lipids Lymphocytes Membrane Potentials Molecules Phospholipids - metabolism Potassium Channels, Voltage-Gated - metabolism Rats Sensors Sphingomyelin Phosphodiesterase - pharmacology Voltage-Gated Sodium Channels - metabolism Xenopus
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