Calmodulin-dependent activation and inactivation of anoctamin calcium-gated chloride channels

Calcium-dependent chloride channels serve critical functions in diverse biological systems. Driven by cellular calcium signals, the channels codetermine excitatory processes and promote solute transport. The anoctamin (ANO) family of membrane proteins encodes three calcium-activated chloride channel...

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Veröffentlicht in:	The Journal of general physiology 2013-10, Vol.142 (4), p.381-404
Hauptverfasser:	Vocke, Kerstin, Dauner, Kristin, Hahn, Anne, Ulbrich, Anne, Broecker, Jana, Keller, Sandro, Frings, Stephan, Möhrlen, Frank
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials Amino Acid Sequence Animals Anoctamin-1 Anoctamins Binding Sites Brain - metabolism Calcium Calcium - metabolism Calmodulin - metabolism Cells Chloride Channels - chemistry Chloride Channels - genetics Chloride Channels - metabolism HEK293 Cells Humans Ion Channel Gating Mice Molecular Sequence Data Mutagenesis Mutation Neurons - metabolism Neurons - physiology Protein Binding Protein Isoforms - genetics Protein Isoforms - metabolism Proteins Rats Retina - metabolism
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