Evidence for deep phylogenetic conservation of exonic splice-related constraints: splice-related skews at exonic ends in the brown alga Ectocarpus are common and resemble those seen in humans

The control of RNA splicing is often modulated by exonic motifs near splice sites. Chief among these are exonic splice enhancers (ESEs). Well-described ESEs in mammals are purine rich and cause predictable skews in codon and amino acid usage toward exonic ends. Looking across species, those with rel...

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Veröffentlicht in:	Genome biology and evolution 2013-01, Vol.5 (9), p.1731-1745
Hauptverfasser:	Wu, Xianming, Tronholm, Ana, Cáceres, Eva Fernández, Tovar-Corona, Jaime M, Chen, Lu, Urrutia, Araxi O, Hurst, Laurence D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Codon - genetics Computational Biology Drosophila - genetics Enhancer Elements, Genetic Evolution, Molecular Exons Humans Introns Phaeophyceae - genetics Phylogeny Regulatory Sequences, Nucleic Acid RNA Splice Sites - genetics RNA Splicing - genetics
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