Polymorphisms in the Human Cytochrome P450 and Arylamine N-Acetyltransferase: Susceptibility to Head and Neck Cancers

The occurrence of head and neck cancer (HNC) is associated with smoking and alcohol drinking. Tobacco smoking exposes smokers to a series of carcinogenic chemicals. Cytochrome P450 enzymes (CYP450s), such as CYP1A1, CYP1B1, and CYP2D6, usually metabolize carcinogens to their inactive derivatives, bu...

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Veröffentlicht in:	BioMed research international 2013-01, Vol.2013 (2013), p.1-20
Hauptverfasser:	Hamza-Chaffai, Amel, Rebaï, Ahmed, Messaoud, Olfa, Khlifi, Rim
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetaldehyde Aryl Hydrocarbon Hydroxylases - genetics Arylamine N-Acetyltransferase - genetics Carcinogens - metabolism Cytochrome P-450 CYP1A1 - genetics Cytochrome P-450 CYP1B1 Cytochrome P-450 CYP2D6 - genetics Cytochrome P-450 CYP2E1 - genetics Genetic Predisposition to Disease Head and Neck Neoplasms - genetics Head and Neck Neoplasms - pathology Humans Isoenzymes - genetics Polymorphism, Single Nucleotide Review Risk Factors
Online-Zugang:	Volltext
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