Effect of Direct-to-Consumer Genomewide Profiling to Assess Disease Risk
In this study, subjects were assessed before and after receiving results of direct-to-consumer genomewide profiling to assess disease risk. Receipt of the results appeared to have no substantial effect on psychological health or behavior; however, 44% of subjects did not complete the follow-up asses...
Gespeichert in:
| Veröffentlicht in: | The New England journal of medicine 2011-02, Vol.364 (6), p.524-534 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 534 |
|---|---|
| container_issue | 6 |
| container_start_page | 524 |
| container_title | The New England journal of medicine |
| container_volume | 364 |
| creator | Bloss, Cinnamon S Schork, Nicholas J Topol, Eric J |
| description | In this study, subjects were assessed before and after receiving results of direct-to-consumer genomewide profiling to assess disease risk. Receipt of the results appeared to have no substantial effect on psychological health or behavior; however, 44% of subjects did not complete the follow-up assessment.
Direct-to-consumer genomewide profiling to assess disease risk provides information about a person's genetic risk of 20 to 40 common polygenic diseases. The tests simultaneously genotype approximately 500,000 variant bases of a person's DNA. Consumers can purchase these tests, currently priced between $400 and $2,000, on the Internet.
1
–
4
Consultation with a health care provider is not a prerequisite. Proponents argue that providing this type of information directly to consumers may result in improved compliance with health-screening practices and more healthful lifestyle choices. Skeptics assert that such testing has the potential to cause harm, including anxiety and increased use of unnecessary . . . |
| doi_str_mv | 10.1056/NEJMoa1011893 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3786730</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2358412141</sourcerecordid><originalsourceid>FETCH-LOGICAL-c583t-22ecc497d5548c9d0ac4f0715d33fec725a0db2b8c1203e0bf506de8d801e0213</originalsourceid><addsrcrecordid>eNp1kc1v1DAQxS0EotvCkSuKkFBPgfFX7FyQqmVpQeVDCM6W15kUL0lcPAmI_x6jLqVFwpexNL9580aPsUccnnHQzfN3mzdvk-fAuW3lHbbiWspaKWjushWAsLUyrTxgh0Q7KI-r9j47EFyIRhtYsbNN32OYq9RXL2Muv3pO9TpNtIyYq1Oc0og_YofVh5z6OMTpoppTdUKERGWC0BNWHyN9fcDu9X4gfLivR-zzq82n9Vl9_v709frkvA7ayrkWAkNQrem0Vja0HfigejBcd1IWI0ZoD91WbG3gAiTCttfQdGg7CxxBcHnEXlzpXi7bEbuA05z94C5zHH3-6ZKP7nZnil_cRfrupLGNkVAEjvcCOX1bkGY3Rgo4DH7CtJCzmiujjdWFfPIPuUtLnsp1zja2aRQYWaD6Cgo5EWXsr61wcL8TcrcSKvzjm_6v6T-RFODpHvAU_NBnP4VIfzlphRI3uXEkN-Fu_M_CX9IHo-k</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>868664073</pqid></control><display><type>article</type><title>Effect of Direct-to-Consumer Genomewide Profiling to Assess Disease Risk</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>ProQuest Central UK/Ireland</source><source>New England Journal of Medicine</source><creator>Bloss, Cinnamon S ; Schork, Nicholas J ; Topol, Eric J</creator><creatorcontrib>Bloss, Cinnamon S ; Schork, Nicholas J ; Topol, Eric J</creatorcontrib><description>In this study, subjects were assessed before and after receiving results of direct-to-consumer genomewide profiling to assess disease risk. Receipt of the results appeared to have no substantial effect on psychological health or behavior; however, 44% of subjects did not complete the follow-up assessment.
Direct-to-consumer genomewide profiling to assess disease risk provides information about a person's genetic risk of 20 to 40 common polygenic diseases. The tests simultaneously genotype approximately 500,000 variant bases of a person's DNA. Consumers can purchase these tests, currently priced between $400 and $2,000, on the Internet.
1
–
4
Consultation with a health care provider is not a prerequisite. Proponents argue that providing this type of information directly to consumers may result in improved compliance with health-screening practices and more healthful lifestyle choices. Skeptics assert that such testing has the potential to cause harm, including anxiety and increased use of unnecessary . . .</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJMoa1011893</identifier><identifier>PMID: 21226570</identifier><identifier>CODEN: NEJMAG</identifier><language>eng</language><publisher>Waltham, MA: Massachusetts Medical Society</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Anxiety - etiology ; Behavior ; Biological and medical sciences ; Commerce ; Consumer Behavior ; Diet ; Dietary Fats - administration & dosage ; Exercise ; Follow-Up Studies ; General aspects ; Genetic Counseling ; Genetic Predisposition to Disease - psychology ; Genetic Testing - psychology ; Genetic Testing - utilization ; Genome, Human ; Health Behavior ; Health risk assessment ; Humans ; Medical sciences ; Middle Aged ; Oils & fats ; Risk Assessment ; Young Adult</subject><ispartof>The New England journal of medicine, 2011-02, Vol.364 (6), p.524-534</ispartof><rights>Copyright © 2011 Massachusetts Medical Society. All rights reserved.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 Massachusetts Medical Society. 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c583t-22ecc497d5548c9d0ac4f0715d33fec725a0db2b8c1203e0bf506de8d801e0213</citedby><cites>FETCH-LOGICAL-c583t-22ecc497d5548c9d0ac4f0715d33fec725a0db2b8c1203e0bf506de8d801e0213</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJMoa1011893$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/868664073?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>230,314,777,781,882,2746,2747,26084,27905,27906,52363,54045,64364,64366,64368,72218</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23824270$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21226570$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bloss, Cinnamon S</creatorcontrib><creatorcontrib>Schork, Nicholas J</creatorcontrib><creatorcontrib>Topol, Eric J</creatorcontrib><title>Effect of Direct-to-Consumer Genomewide Profiling to Assess Disease Risk</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>In this study, subjects were assessed before and after receiving results of direct-to-consumer genomewide profiling to assess disease risk. Receipt of the results appeared to have no substantial effect on psychological health or behavior; however, 44% of subjects did not complete the follow-up assessment.
Direct-to-consumer genomewide profiling to assess disease risk provides information about a person's genetic risk of 20 to 40 common polygenic diseases. The tests simultaneously genotype approximately 500,000 variant bases of a person's DNA. Consumers can purchase these tests, currently priced between $400 and $2,000, on the Internet.
1
–
4
Consultation with a health care provider is not a prerequisite. Proponents argue that providing this type of information directly to consumers may result in improved compliance with health-screening practices and more healthful lifestyle choices. Skeptics assert that such testing has the potential to cause harm, including anxiety and increased use of unnecessary . . .</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Anxiety - etiology</subject><subject>Behavior</subject><subject>Biological and medical sciences</subject><subject>Commerce</subject><subject>Consumer Behavior</subject><subject>Diet</subject><subject>Dietary Fats - administration & dosage</subject><subject>Exercise</subject><subject>Follow-Up Studies</subject><subject>General aspects</subject><subject>Genetic Counseling</subject><subject>Genetic Predisposition to Disease - psychology</subject><subject>Genetic Testing - psychology</subject><subject>Genetic Testing - utilization</subject><subject>Genome, Human</subject><subject>Health Behavior</subject><subject>Health risk assessment</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Oils & fats</subject><subject>Risk Assessment</subject><subject>Young Adult</subject><issn>0028-4793</issn><issn>1533-4406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp1kc1v1DAQxS0EotvCkSuKkFBPgfFX7FyQqmVpQeVDCM6W15kUL0lcPAmI_x6jLqVFwpexNL9580aPsUccnnHQzfN3mzdvk-fAuW3lHbbiWspaKWjushWAsLUyrTxgh0Q7KI-r9j47EFyIRhtYsbNN32OYq9RXL2Muv3pO9TpNtIyYq1Oc0og_YofVh5z6OMTpoppTdUKERGWC0BNWHyN9fcDu9X4gfLivR-zzq82n9Vl9_v709frkvA7ayrkWAkNQrem0Vja0HfigejBcd1IWI0ZoD91WbG3gAiTCttfQdGg7CxxBcHnEXlzpXi7bEbuA05z94C5zHH3-6ZKP7nZnil_cRfrupLGNkVAEjvcCOX1bkGY3Rgo4DH7CtJCzmiujjdWFfPIPuUtLnsp1zja2aRQYWaD6Cgo5EWXsr61wcL8TcrcSKvzjm_6v6T-RFODpHvAU_NBnP4VIfzlphRI3uXEkN-Fu_M_CX9IHo-k</recordid><startdate>20110210</startdate><enddate>20110210</enddate><creator>Bloss, Cinnamon S</creator><creator>Schork, Nicholas J</creator><creator>Topol, Eric J</creator><general>Massachusetts Medical Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0TZ</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K0Y</scope><scope>LK8</scope><scope>M0R</scope><scope>M0T</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20110210</creationdate><title>Effect of Direct-to-Consumer Genomewide Profiling to Assess Disease Risk</title><author>Bloss, Cinnamon S ; Schork, Nicholas J ; Topol, Eric J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c583t-22ecc497d5548c9d0ac4f0715d33fec725a0db2b8c1203e0bf506de8d801e0213</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Anxiety - etiology</topic><topic>Behavior</topic><topic>Biological and medical sciences</topic><topic>Commerce</topic><topic>Consumer Behavior</topic><topic>Diet</topic><topic>Dietary Fats - administration & dosage</topic><topic>Exercise</topic><topic>Follow-Up Studies</topic><topic>General aspects</topic><topic>Genetic Counseling</topic><topic>Genetic Predisposition to Disease - psychology</topic><topic>Genetic Testing - psychology</topic><topic>Genetic Testing - utilization</topic><topic>Genome, Human</topic><topic>Health Behavior</topic><topic>Health risk assessment</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Oils & fats</topic><topic>Risk Assessment</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bloss, Cinnamon S</creatorcontrib><creatorcontrib>Schork, Nicholas J</creatorcontrib><creatorcontrib>Topol, Eric J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Pharma and Biotech Premium PRO</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>New England Journal of Medicine</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The New England journal of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bloss, Cinnamon S</au><au>Schork, Nicholas J</au><au>Topol, Eric J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Direct-to-Consumer Genomewide Profiling to Assess Disease Risk</atitle><jtitle>The New England journal of medicine</jtitle><addtitle>N Engl J Med</addtitle><date>2011-02-10</date><risdate>2011</risdate><volume>364</volume><issue>6</issue><spage>524</spage><epage>534</epage><pages>524-534</pages><issn>0028-4793</issn><eissn>1533-4406</eissn><coden>NEJMAG</coden><abstract>In this study, subjects were assessed before and after receiving results of direct-to-consumer genomewide profiling to assess disease risk. Receipt of the results appeared to have no substantial effect on psychological health or behavior; however, 44% of subjects did not complete the follow-up assessment.
Direct-to-consumer genomewide profiling to assess disease risk provides information about a person's genetic risk of 20 to 40 common polygenic diseases. The tests simultaneously genotype approximately 500,000 variant bases of a person's DNA. Consumers can purchase these tests, currently priced between $400 and $2,000, on the Internet.
1
–
4
Consultation with a health care provider is not a prerequisite. Proponents argue that providing this type of information directly to consumers may result in improved compliance with health-screening practices and more healthful lifestyle choices. Skeptics assert that such testing has the potential to cause harm, including anxiety and increased use of unnecessary . . .</abstract><cop>Waltham, MA</cop><pub>Massachusetts Medical Society</pub><pmid>21226570</pmid><doi>10.1056/NEJMoa1011893</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0028-4793 |
| ispartof | The New England journal of medicine, 2011-02, Vol.364 (6), p.524-534 |
| issn | 0028-4793 1533-4406 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3786730 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; ProQuest Central UK/Ireland; New England Journal of Medicine |
| subjects | Adult Aged Aged, 80 and over Anxiety - etiology Behavior Biological and medical sciences Commerce Consumer Behavior Diet Dietary Fats - administration & dosage Exercise Follow-Up Studies General aspects Genetic Counseling Genetic Predisposition to Disease - psychology Genetic Testing - psychology Genetic Testing - utilization Genome, Human Health Behavior Health risk assessment Humans Medical sciences Middle Aged Oils & fats Risk Assessment Young Adult |
| title | Effect of Direct-to-Consumer Genomewide Profiling to Assess Disease Risk |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-20T12%3A26%3A35IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effect%20of%20Direct-to-Consumer%20Genomewide%20Profiling%20to%20Assess%20Disease%20Risk&rft.jtitle=The%20New%20England%20journal%20of%20medicine&rft.au=Bloss,%20Cinnamon%20S&rft.date=2011-02-10&rft.volume=364&rft.issue=6&rft.spage=524&rft.epage=534&rft.pages=524-534&rft.issn=0028-4793&rft.eissn=1533-4406&rft.coden=NEJMAG&rft_id=info:doi/10.1056/NEJMoa1011893&rft_dat=%3Cproquest_pubme%3E2358412141%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=868664073&rft_id=info:pmid/21226570&rfr_iscdi=true |