The genetic contribution to severe post-traumatic osteoarthritis
Objective to compare the combined role of genetic variants loci associated with risk of knee or hip osteoarthritis (OA) in post-traumatic (PT) and non-traumatic (NT) cases of clinically severe OA leading to total joint replacement. Methods A total of 1590 controls, 2168 total knee replacement (TKR)...
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| Veröffentlicht in: | Annals of the rheumatic diseases 2013-10, Vol.72 (10), p.1687-1690 |
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| creator | Valdes, Ana M Doherty, Sally A Muir, Kenneth R Wheeler, Margaret Maciewicz, Rose A Zhang, Weiya Doherty, Michael |
| description | Objective to compare the combined role of genetic variants loci associated with risk of knee or hip osteoarthritis (OA) in post-traumatic (PT) and non-traumatic (NT) cases of clinically severe OA leading to total joint replacement. Methods A total of 1590 controls, 2168 total knee replacement (TKR) cases (33.2% PT) and 1567 total hip replacement (THR) cases (8.7% PT) from 2 UK cohorts were genotyped for 12 variants previously reported to be reproducibly associated with risk of knee or hip OA. A genetic risk score was generated and the association with PT and NT TKR and THR was assessed adjusting for covariates. Results For THR, each additional genetic risk variant conferred lower risk among PT cases (OR=1.07, 95% CI 0.96 to 1.19; p=0.24) than NT cases (OR 1.11, 95% CI 1.06 to 1.17; p=1.55×10−5). In contrast, for TKR, each risk variant conferred slightly higher risk among PT cases (OR 1.12, 95% CI 1.07 to 1.19; p=1.82×10−5) than among NT cases (OR 1.08, 95% CI 1.03 to 1.1; p=0.00063). Conclusions Based on the variants reported to date PT TKR cases have at least as high a genetic contribution as NT cases. |
| doi_str_mv | 10.1136/annrheumdis-2012-202562 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3786638</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1430848580</sourcerecordid><originalsourceid>FETCH-LOGICAL-b559t-a09a1b5a5d1289c494f549e4c8055a128995c4eae728d5421447fac5c054aa7b3</originalsourceid><addsrcrecordid>eNqNkU9vEzEQxS0EomnhK0AkLlwW_N_eCwKtoCAqkFDhwMWadSaNQ3YdbG8F3x5HW6LCBS62xvObp-d5hDxm9BljQj-HcUwbnIZVyA2njNeDK83vkAWT2tZK07tkQSkVjWy1OSGnOW9rSS2z98kJF0IpRs2CvLzc4PIKRyzBL30cSwr9VEIclyUuM15jwuU-5tKUBNMAB6pWGCGVTQol5Afk3hp2GR_e3Gfk85vXl93b5uLj-bvu1UXTK9WWBmgLrFegVozb1stWrpVsUXpLlYLDW6u8REDD7UpJzqQ0a_DKUyUBTC_OyItZdz_1A648Vquwc_sUBkg_XYTg_uyMYeOu4rUTxmotbBV4eiOQ4vcJc3FDyB53OxgxTtkxzZjmVLbm36gU1EqrLK3ok7_QbZzSWDfhmDHGWlV3XikzUz7FnBOuj74ZdYdA3a1A3SFQNwdaJx_d_vZx7neCFWhmINRYfhz7kL45bYRR7sOXznVSf-q-vhdOVZ7PfD9s_9vFL759v0k</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1777885008</pqid></control><display><type>article</type><title>The genetic contribution to severe post-traumatic osteoarthritis</title><source>MEDLINE</source><source>BMJ Journals - NESLi2</source><creator>Valdes, Ana M ; Doherty, Sally A ; Muir, Kenneth R ; Wheeler, Margaret ; Maciewicz, Rose A ; Zhang, Weiya ; Doherty, Michael</creator><creatorcontrib>Valdes, Ana M ; Doherty, Sally A ; Muir, Kenneth R ; Wheeler, Margaret ; Maciewicz, Rose A ; Zhang, Weiya ; Doherty, Michael</creatorcontrib><description>Objective to compare the combined role of genetic variants loci associated with risk of knee or hip osteoarthritis (OA) in post-traumatic (PT) and non-traumatic (NT) cases of clinically severe OA leading to total joint replacement. Methods A total of 1590 controls, 2168 total knee replacement (TKR) cases (33.2% PT) and 1567 total hip replacement (THR) cases (8.7% PT) from 2 UK cohorts were genotyped for 12 variants previously reported to be reproducibly associated with risk of knee or hip OA. A genetic risk score was generated and the association with PT and NT TKR and THR was assessed adjusting for covariates. Results For THR, each additional genetic risk variant conferred lower risk among PT cases (OR=1.07, 95% CI 0.96 to 1.19; p=0.24) than NT cases (OR 1.11, 95% CI 1.06 to 1.17; p=1.55×10−5). In contrast, for TKR, each risk variant conferred slightly higher risk among PT cases (OR 1.12, 95% CI 1.07 to 1.19; p=1.82×10−5) than among NT cases (OR 1.08, 95% CI 1.03 to 1.1; p=0.00063). Conclusions Based on the variants reported to date PT TKR cases have at least as high a genetic contribution as NT cases.</description><identifier>ISSN: 0003-4967</identifier><identifier>EISSN: 1468-2060</identifier><identifier>DOI: 10.1136/annrheumdis-2012-202562</identifier><identifier>PMID: 23355107</identifier><identifier>CODEN: ARDIAO</identifier><language>eng</language><publisher>England: BMJ Publishing Group Ltd and European League Against Rheumatism</publisher><subject>Aged ; Arthritis ; Arthroplasty, Replacement, Hip ; Arthroplasty, Replacement, Knee ; Body Mass Index ; Case-Control Studies ; Clinical and Epidemiological Research ; Epidemiology ; Female ; Gene Polymorphism ; Genes ; Genetic Predisposition to Disease ; Hip Injuries - complications ; Humans ; Knee ; Knee Injuries - complications ; Male ; Middle Aged ; Osteoarthritis ; Osteoarthritis, Hip - etiology ; Osteoarthritis, Hip - genetics ; Osteoarthritis, Hip - surgery ; Osteoarthritis, Knee - etiology ; Osteoarthritis, Knee - genetics ; Osteoarthritis, Knee - surgery ; Risk Factors</subject><ispartof>Annals of the rheumatic diseases, 2013-10, Vol.72 (10), p.1687-1690</ispartof><rights>Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions</rights><rights>Copyright: 2013 Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions</rights><rights>Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b559t-a09a1b5a5d1289c494f549e4c8055a128995c4eae728d5421447fac5c054aa7b3</citedby><cites>FETCH-LOGICAL-b559t-a09a1b5a5d1289c494f549e4c8055a128995c4eae728d5421447fac5c054aa7b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttp://ard.bmj.com/content/72/10/1687.full.pdf$$EPDF$$P50$$Gbmj$$Hfree_for_read</linktopdf><linktohtml>$$Uhttp://ard.bmj.com/content/72/10/1687.full$$EHTML$$P50$$Gbmj$$Hfree_for_read</linktohtml><link.rule.ids>114,115,230,314,780,784,885,3196,23571,27924,27925,77600,77631</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23355107$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Valdes, Ana M</creatorcontrib><creatorcontrib>Doherty, Sally A</creatorcontrib><creatorcontrib>Muir, Kenneth R</creatorcontrib><creatorcontrib>Wheeler, Margaret</creatorcontrib><creatorcontrib>Maciewicz, Rose A</creatorcontrib><creatorcontrib>Zhang, Weiya</creatorcontrib><creatorcontrib>Doherty, Michael</creatorcontrib><title>The genetic contribution to severe post-traumatic osteoarthritis</title><title>Annals of the rheumatic diseases</title><addtitle>Ann Rheum Dis</addtitle><description>Objective to compare the combined role of genetic variants loci associated with risk of knee or hip osteoarthritis (OA) in post-traumatic (PT) and non-traumatic (NT) cases of clinically severe OA leading to total joint replacement. Methods A total of 1590 controls, 2168 total knee replacement (TKR) cases (33.2% PT) and 1567 total hip replacement (THR) cases (8.7% PT) from 2 UK cohorts were genotyped for 12 variants previously reported to be reproducibly associated with risk of knee or hip OA. A genetic risk score was generated and the association with PT and NT TKR and THR was assessed adjusting for covariates. Results For THR, each additional genetic risk variant conferred lower risk among PT cases (OR=1.07, 95% CI 0.96 to 1.19; p=0.24) than NT cases (OR 1.11, 95% CI 1.06 to 1.17; p=1.55×10−5). In contrast, for TKR, each risk variant conferred slightly higher risk among PT cases (OR 1.12, 95% CI 1.07 to 1.19; p=1.82×10−5) than among NT cases (OR 1.08, 95% CI 1.03 to 1.1; p=0.00063). Conclusions Based on the variants reported to date PT TKR cases have at least as high a genetic contribution as NT cases.</description><subject>Aged</subject><subject>Arthritis</subject><subject>Arthroplasty, Replacement, Hip</subject><subject>Arthroplasty, Replacement, Knee</subject><subject>Body Mass Index</subject><subject>Case-Control Studies</subject><subject>Clinical and Epidemiological Research</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Gene Polymorphism</subject><subject>Genes</subject><subject>Genetic Predisposition to Disease</subject><subject>Hip Injuries - complications</subject><subject>Humans</subject><subject>Knee</subject><subject>Knee Injuries - complications</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Osteoarthritis</subject><subject>Osteoarthritis, Hip - etiology</subject><subject>Osteoarthritis, Hip - genetics</subject><subject>Osteoarthritis, Hip - surgery</subject><subject>Osteoarthritis, Knee - etiology</subject><subject>Osteoarthritis, Knee - genetics</subject><subject>Osteoarthritis, Knee - surgery</subject><subject>Risk Factors</subject><issn>0003-4967</issn><issn>1468-2060</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>9YT</sourceid><sourceid>ACMMV</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkU9vEzEQxS0EomnhK0AkLlwW_N_eCwKtoCAqkFDhwMWadSaNQ3YdbG8F3x5HW6LCBS62xvObp-d5hDxm9BljQj-HcUwbnIZVyA2njNeDK83vkAWT2tZK07tkQSkVjWy1OSGnOW9rSS2z98kJF0IpRs2CvLzc4PIKRyzBL30cSwr9VEIclyUuM15jwuU-5tKUBNMAB6pWGCGVTQol5Afk3hp2GR_e3Gfk85vXl93b5uLj-bvu1UXTK9WWBmgLrFegVozb1stWrpVsUXpLlYLDW6u8REDD7UpJzqQ0a_DKUyUBTC_OyItZdz_1A648Vquwc_sUBkg_XYTg_uyMYeOu4rUTxmotbBV4eiOQ4vcJc3FDyB53OxgxTtkxzZjmVLbm36gU1EqrLK3ok7_QbZzSWDfhmDHGWlV3XikzUz7FnBOuj74ZdYdA3a1A3SFQNwdaJx_d_vZx7neCFWhmINRYfhz7kL45bYRR7sOXznVSf-q-vhdOVZ7PfD9s_9vFL759v0k</recordid><startdate>20131001</startdate><enddate>20131001</enddate><creator>Valdes, Ana M</creator><creator>Doherty, Sally A</creator><creator>Muir, Kenneth R</creator><creator>Wheeler, Margaret</creator><creator>Maciewicz, Rose A</creator><creator>Zhang, Weiya</creator><creator>Doherty, Michael</creator><general>BMJ Publishing Group Ltd and European League Against Rheumatism</general><general>BMJ Publishing Group LTD</general><general>BMJ Publishing Group</general><scope>9YT</scope><scope>ACMMV</scope><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>LK8</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>7QP</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>5PM</scope></search><sort><creationdate>20131001</creationdate><title>The genetic contribution to severe post-traumatic osteoarthritis</title><author>Valdes, Ana M ; Doherty, Sally A ; Muir, Kenneth R ; Wheeler, Margaret ; Maciewicz, Rose A ; Zhang, Weiya ; Doherty, Michael</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b559t-a09a1b5a5d1289c494f549e4c8055a128995c4eae728d5421447fac5c054aa7b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Aged</topic><topic>Arthritis</topic><topic>Arthroplasty, Replacement, Hip</topic><topic>Arthroplasty, Replacement, Knee</topic><topic>Body Mass Index</topic><topic>Case-Control Studies</topic><topic>Clinical and Epidemiological Research</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Gene Polymorphism</topic><topic>Genes</topic><topic>Genetic Predisposition to Disease</topic><topic>Hip Injuries - complications</topic><topic>Humans</topic><topic>Knee</topic><topic>Knee Injuries - complications</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Osteoarthritis</topic><topic>Osteoarthritis, Hip - etiology</topic><topic>Osteoarthritis, Hip - genetics</topic><topic>Osteoarthritis, Hip - surgery</topic><topic>Osteoarthritis, Knee - etiology</topic><topic>Osteoarthritis, Knee - genetics</topic><topic>Osteoarthritis, Knee - surgery</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Valdes, Ana M</creatorcontrib><creatorcontrib>Doherty, Sally A</creatorcontrib><creatorcontrib>Muir, Kenneth R</creatorcontrib><creatorcontrib>Wheeler, Margaret</creatorcontrib><creatorcontrib>Maciewicz, Rose A</creatorcontrib><creatorcontrib>Zhang, Weiya</creatorcontrib><creatorcontrib>Doherty, Michael</creatorcontrib><collection>BMJ Open Access Journals</collection><collection>BMJ Journals:Open Access</collection><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Annals of the rheumatic diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Valdes, Ana M</au><au>Doherty, Sally A</au><au>Muir, Kenneth R</au><au>Wheeler, Margaret</au><au>Maciewicz, Rose A</au><au>Zhang, Weiya</au><au>Doherty, Michael</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The genetic contribution to severe post-traumatic osteoarthritis</atitle><jtitle>Annals of the rheumatic diseases</jtitle><addtitle>Ann Rheum Dis</addtitle><date>2013-10-01</date><risdate>2013</risdate><volume>72</volume><issue>10</issue><spage>1687</spage><epage>1690</epage><pages>1687-1690</pages><issn>0003-4967</issn><eissn>1468-2060</eissn><coden>ARDIAO</coden><abstract>Objective to compare the combined role of genetic variants loci associated with risk of knee or hip osteoarthritis (OA) in post-traumatic (PT) and non-traumatic (NT) cases of clinically severe OA leading to total joint replacement. Methods A total of 1590 controls, 2168 total knee replacement (TKR) cases (33.2% PT) and 1567 total hip replacement (THR) cases (8.7% PT) from 2 UK cohorts were genotyped for 12 variants previously reported to be reproducibly associated with risk of knee or hip OA. A genetic risk score was generated and the association with PT and NT TKR and THR was assessed adjusting for covariates. Results For THR, each additional genetic risk variant conferred lower risk among PT cases (OR=1.07, 95% CI 0.96 to 1.19; p=0.24) than NT cases (OR 1.11, 95% CI 1.06 to 1.17; p=1.55×10−5). In contrast, for TKR, each risk variant conferred slightly higher risk among PT cases (OR 1.12, 95% CI 1.07 to 1.19; p=1.82×10−5) than among NT cases (OR 1.08, 95% CI 1.03 to 1.1; p=0.00063). Conclusions Based on the variants reported to date PT TKR cases have at least as high a genetic contribution as NT cases.</abstract><cop>England</cop><pub>BMJ Publishing Group Ltd and European League Against Rheumatism</pub><pmid>23355107</pmid><doi>10.1136/annrheumdis-2012-202562</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Arthritis Arthroplasty, Replacement, Hip Arthroplasty, Replacement, Knee Body Mass Index Case-Control Studies Clinical and Epidemiological Research Epidemiology Female Gene Polymorphism Genes Genetic Predisposition to Disease Hip Injuries - complications Humans Knee Knee Injuries - complications Male Middle Aged Osteoarthritis Osteoarthritis, Hip - etiology Osteoarthritis, Hip - genetics Osteoarthritis, Hip - surgery Osteoarthritis, Knee - etiology Osteoarthritis, Knee - genetics Osteoarthritis, Knee - surgery Risk Factors |
| title | The genetic contribution to severe post-traumatic osteoarthritis |
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