PI(3) kinase is associated with a mechanism of immunoresistance in breast and prostate cancer

Immune escape describes a critical event whereby tumor cells adopt an immunoresistant phenotype to escape adaptive surveillance. We show that expression of a pivotal negative regulator of T-cell function, B7-H1, correlates with PI(3) kinase activation in breast and prostate cancer patients. B7-H1-me...

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Veröffentlicht in:	Oncogene 2009-01, Vol.28 (2), p.306-312
Hauptverfasser:	Crane, C A, Panner, A, Murray, J C, Wilson, S P, Xu, H, Chen, L, Simko, J P, Waldman, F M, Pieper, R O, Parsa, A T
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - enzymology Adenocarcinoma - immunology Adenocarcinoma - pathology Antigens, CD - genetics Antigens, CD - physiology Apoptosis B7-H1 Antigen Biological and medical sciences Breast cancer Breast Neoplasms - enzymology Breast Neoplasms - immunology Breast Neoplasms - pathology Care and treatment Cell Biology Cell Line, Tumor - drug effects Cell Line, Tumor - enzymology Cell Line, Tumor - immunology Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Female Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Neoplastic Gene Knockdown Techniques Genetic aspects Genotype & phenotype Gynecology. Andrology. Obstetrics Health aspects Human Genetics Humans Immune response Immune system Internal Medicine Kinases Leukocytes Male Mammary gland diseases Medical sciences Medicine Medicine & Public Health Molecular and cellular biology Neoplasm Proteins - antagonists & inhibitors Neoplasm Proteins - genetics Neoplasm Proteins - physiology Nephrology. Urinary tract diseases Oncology Phenotype Phosphatidylinositol 3-Kinases - antagonists & inhibitors Phosphatidylinositol 3-Kinases - physiology Prostate cancer Prostatic Neoplasms - enzymology Prostatic Neoplasms - immunology Prostatic Neoplasms - pathology Protein Kinase Inhibitors - pharmacology Protein kinases PTEN Phosphohydrolase - physiology Recombinant Fusion Proteins - physiology Ribosomal Protein S6 Kinases - physiology RNA, Small Interfering - pharmacology short-communication T-Lymphocytes, Cytotoxic - immunology Tumor Escape - drug effects Tumor Escape - genetics Tumor Escape - immunology Tumors Tumors of the urinary system Urinary tract. Prostate gland
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