Convection-enhanced delivery of M13 bacteriophage to the brain

Recent studies indicate that M13 bacteriophage, a very large nanoparticle, binds to β-amyloid and α-synuclein proteins, leading to plaque disaggregation in models of Alzheimer and Parkinson disease. To determine the feasibility, safety, and characteristics of convection-enhanced delivery (CED) of M1...

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Veröffentlicht in:	Journal of neurosurgery 2012-08, Vol.117 (2), p.197-203
Hauptverfasser:	Ksendzovsky, Alexander, Walbridge, Stuart, Saunders, Richard C, Asthagiri, Ashok R, Heiss, John D, Lonser, Russell R
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - pathology Alzheimer Disease - therapy Animals Bacteriophage M13 - metabolism Cerebral Infarction - pathology Contrast Media Convection Disease Models, Animal Frontal Lobe - metabolism Frontal Lobe - pathology Gadolinium DTPA Gliosis - pathology Image Interpretation, Computer-Assisted Macaca mulatta Magnetic Resonance Imaging Nanoparticles Neurologic Examination Parkinson Disease - pathology Parkinson Disease - therapy Thalamus - metabolism Thalamus - pathology
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