A serotonin-induced N-glycan switch regulates platelet aggregation

Serotonin (5-HT) is a multifunctional signaling molecule that plays different roles in a concentration-dependent manner. We demonstrated that elevated levels of plasma 5-HT accelerate platelet aggregation resulting in a hypercoagulable state in which the platelet surface becomes occupied by several...

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Veröffentlicht in:	Scientific reports 2013-09, Vol.3 (1), p.2795, Article 2795
Hauptverfasser:	Mercado, Charles P., Quintero, Maritza V., Li, Yicong, Singh, Preeti, Byrd, Alicia K., Talabnin, Krajang, Ishihara, Mayumi, Azadi, Parastoo, Rusch, Nancy J., Kuberan, Balagurunathan, Maroteaux, Luc, Kilic, Fusun
Format:	Artikel
Sprache:	eng
Schlagworte:	631/45 631/45/607/1164 631/80/313/2376 631/92/221 Animals Biochemistry, Molecular Biology Biological Markers Biomarkers - metabolism Blood Platelets Blood Platelets - drug effects Blood Platelets - enzymology Cell Membrane Cell Membrane - drug effects Cell Membrane - metabolism Chemical Fractionation Chromatography, Liquid Flow Cytometry Glycoproteins Humanities and Social Sciences Hydroxylase Life Sciences Male Mass Spectrometry Mass spectroscopy Mice Mice, Inbred C57BL Mixed Function Oxygenases Mixed Function Oxygenases - blood Mixed Function Oxygenases - genetics multidisciplinary N-Acetylneuraminic Acid N-Acetylneuraminic Acid - chemistry N-Acetylneuraminic Acid - metabolism N-glycans Platelet Aggregation Platelet Aggregation - drug effects Polysaccharides Polysaccharides - chemistry Polysaccharides - metabolism Rodents Science Serotonin Serotonin - pharmacology
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