Urinary-Cell mRNA Profile and Acute Cellular Rejection in Kidney Allografts
Noninvasive means for diagnosing acute rejection in kidney transplants are needed. This study prospectively measured mRNA in urinary cells from kidney-allograft recipients. A three-gene signature appeared to be diagnostic and prognostic of acute cellular rejection. Kidney transplantation is consider...
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| Veröffentlicht in: | The New England journal of medicine 2013-07, Vol.369 (1), p.20-31 |
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| creator | Suthanthiran, Manikkam Schwartz, Joseph E Ding, Ruchuang Abecassis, Michael Dadhania, Darshana Samstein, Benjamin Knechtle, Stuart J Friedewald, John Becker, Yolanda T Sharma, Vijay K Williams, Nikki M Chang, Christina S Hoang, Christine Muthukumar, Thangamani August, Phyllis Keslar, Karen S Fairchild, Robert L Hricik, Donald E Heeger, Peter S Han, Leiya Liu, Jun Riggs, Michael Ikle, David N Bridges, Nancy D Shaked, Abraham |
| description | Noninvasive means for diagnosing acute rejection in kidney transplants are needed. This study prospectively measured mRNA in urinary cells from kidney-allograft recipients. A three-gene signature appeared to be diagnostic and prognostic of acute cellular rejection.
Kidney transplantation is considered the best available treatment for patients with end-stage renal disease (ESRD), but acute rejection, a leading cause of new cases of ESRD, undermines its full benefits.
1
–
3
Acute rejection is diagnosed by means of needle biopsy. Over time, this invasive procedure has become safer, and biopsy interpretation more standardized.
4
Nevertheless, bleeding and subsequent graft loss still occur, and sampling errors and interobserver variability in biopsy reading remain problematic.
5
Repeated biopsies to assess the recipient's status pose challenges, including feasibility and cost.
Immunosuppressive drugs effectively treat acute rejection; a noninvasive means of diagnosing this reversible cause of . . . |
| doi_str_mv | 10.1056/NEJMoa1215555 |
| format | Article |
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Kidney transplantation is considered the best available treatment for patients with end-stage renal disease (ESRD), but acute rejection, a leading cause of new cases of ESRD, undermines its full benefits.
1
–
3
Acute rejection is diagnosed by means of needle biopsy. Over time, this invasive procedure has become safer, and biopsy interpretation more standardized.
4
Nevertheless, bleeding and subsequent graft loss still occur, and sampling errors and interobserver variability in biopsy reading remain problematic.
5
Repeated biopsies to assess the recipient's status pose challenges, including feasibility and cost.
Immunosuppressive drugs effectively treat acute rejection; a noninvasive means of diagnosing this reversible cause of . . .</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJMoa1215555</identifier><identifier>PMID: 23822777</identifier><identifier>CODEN: NEJMAG</identifier><language>eng</language><publisher>Waltham, MA: Massachusetts Medical Society</publisher><subject>Acute Disease ; Adult ; Allografts ; Antibodies ; Area Under Curve ; Biological and medical sciences ; Biopsy ; Chemokine CXCL10 - genetics ; Chemokine CXCL10 - urine ; Female ; Gene expression ; General aspects ; Graft rejection ; Graft Rejection - diagnosis ; Graft Rejection - genetics ; Humans ; Interferon ; Interferon-inducible protein ; Interleukin 2 ; Intracellular Signaling Peptides and Proteins - genetics ; Intracellular Signaling Peptides and Proteins - urine ; IP-10 protein ; Kidney Transplantation ; Lymphocytes T ; Male ; Medical sciences ; Middle Aged ; mRNA ; Prospective Studies ; Quality control ; Real-Time Polymerase Chain Reaction ; RNA, Messenger - urine ; RNA, Ribosomal - urine ; RNA, Ribosomal, 18S - urine ; ROC Curve ; rRNA 18S ; Sensitivity and Specificity ; Statistical analysis ; Transcriptome ; Transplants & implants ; Urinary tract ; Urinary tract infections ; Urine</subject><ispartof>The New England journal of medicine, 2013-07, Vol.369 (1), p.20-31</ispartof><rights>Copyright © 2013 Massachusetts Medical Society. All rights reserved.</rights><rights>2014 INIST-CNRS</rights><rights>Copyright © 2013 Massachusetts Medical Society. 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c585t-513ceaf9ecda8acb890da685b99de4f1573daa7190b2565c382716145e9b27793</citedby><cites>FETCH-LOGICAL-c585t-513ceaf9ecda8acb890da685b99de4f1573daa7190b2565c382716145e9b27793</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJMoa1215555$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.nejm.org/doi/full/10.1056/NEJMoa1215555$$EHTML$$P50$$Gmms$$H</linktohtml><link.rule.ids>230,314,776,780,881,2746,2747,26080,27901,27902,52357,54039</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27453805$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23822777$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Suthanthiran, Manikkam</creatorcontrib><creatorcontrib>Schwartz, Joseph E</creatorcontrib><creatorcontrib>Ding, Ruchuang</creatorcontrib><creatorcontrib>Abecassis, Michael</creatorcontrib><creatorcontrib>Dadhania, Darshana</creatorcontrib><creatorcontrib>Samstein, Benjamin</creatorcontrib><creatorcontrib>Knechtle, Stuart J</creatorcontrib><creatorcontrib>Friedewald, John</creatorcontrib><creatorcontrib>Becker, Yolanda T</creatorcontrib><creatorcontrib>Sharma, Vijay K</creatorcontrib><creatorcontrib>Williams, Nikki M</creatorcontrib><creatorcontrib>Chang, Christina S</creatorcontrib><creatorcontrib>Hoang, Christine</creatorcontrib><creatorcontrib>Muthukumar, Thangamani</creatorcontrib><creatorcontrib>August, Phyllis</creatorcontrib><creatorcontrib>Keslar, Karen S</creatorcontrib><creatorcontrib>Fairchild, Robert L</creatorcontrib><creatorcontrib>Hricik, Donald E</creatorcontrib><creatorcontrib>Heeger, Peter S</creatorcontrib><creatorcontrib>Han, Leiya</creatorcontrib><creatorcontrib>Liu, Jun</creatorcontrib><creatorcontrib>Riggs, Michael</creatorcontrib><creatorcontrib>Ikle, David N</creatorcontrib><creatorcontrib>Bridges, Nancy D</creatorcontrib><creatorcontrib>Shaked, Abraham</creatorcontrib><creatorcontrib>Clinical Trials in Organ Transplantation 04 (CTOT-04) Study Investigators</creatorcontrib><title>Urinary-Cell mRNA Profile and Acute Cellular Rejection in Kidney Allografts</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>Noninvasive means for diagnosing acute rejection in kidney transplants are needed. This study prospectively measured mRNA in urinary cells from kidney-allograft recipients. A three-gene signature appeared to be diagnostic and prognostic of acute cellular rejection.
Kidney transplantation is considered the best available treatment for patients with end-stage renal disease (ESRD), but acute rejection, a leading cause of new cases of ESRD, undermines its full benefits.
1
–
3
Acute rejection is diagnosed by means of needle biopsy. Over time, this invasive procedure has become safer, and biopsy interpretation more standardized.
4
Nevertheless, bleeding and subsequent graft loss still occur, and sampling errors and interobserver variability in biopsy reading remain problematic.
5
Repeated biopsies to assess the recipient's status pose challenges, including feasibility and cost.
Immunosuppressive drugs effectively treat acute rejection; a noninvasive means of diagnosing this reversible cause of . . .</description><subject>Acute Disease</subject><subject>Adult</subject><subject>Allografts</subject><subject>Antibodies</subject><subject>Area Under Curve</subject><subject>Biological and medical sciences</subject><subject>Biopsy</subject><subject>Chemokine CXCL10 - genetics</subject><subject>Chemokine CXCL10 - urine</subject><subject>Female</subject><subject>Gene expression</subject><subject>General aspects</subject><subject>Graft rejection</subject><subject>Graft Rejection - diagnosis</subject><subject>Graft Rejection - genetics</subject><subject>Humans</subject><subject>Interferon</subject><subject>Interferon-inducible protein</subject><subject>Interleukin 2</subject><subject>Intracellular Signaling Peptides and Proteins - genetics</subject><subject>Intracellular Signaling Peptides and Proteins - urine</subject><subject>IP-10 protein</subject><subject>Kidney Transplantation</subject><subject>Lymphocytes T</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>mRNA</subject><subject>Prospective Studies</subject><subject>Quality control</subject><subject>Real-Time Polymerase Chain Reaction</subject><subject>RNA, Messenger - urine</subject><subject>RNA, Ribosomal - urine</subject><subject>RNA, Ribosomal, 18S - urine</subject><subject>ROC Curve</subject><subject>rRNA 18S</subject><subject>Sensitivity and Specificity</subject><subject>Statistical analysis</subject><subject>Transcriptome</subject><subject>Transplants & implants</subject><subject>Urinary tract</subject><subject>Urinary tract infections</subject><subject>Urine</subject><issn>0028-4793</issn><issn>1533-4406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp1kM1P3DAQxS1UBFvokSuyVPWYYsdxbF-QVitKCxQqVM7WxHHAK8emdlKJ_x4jtnwc-i5zmJ_evHkIHVDylRLeHl2enP2MQGvKi7bQgnLGqqYh7Qe0IKSWVSMU20Ufc16TItqoHbRbM1nXQogFOr9JLkB6qFbWezxeXy7xrxQH5y2G0OOlmSeLn3azh4Sv7dqaycWAXcDnrg_2AS-9j7cJhinvo-0BfLafNnMP3Xw7-b36Xl1cnf5YLS8qwyWfKk6ZsTAoa3qQYDqpSA-t5J1SvW0GygXrAQRVpKt5y03JKmhLG25VV0IrtoeOn33v5260vbFhSuD1fXJj-URHcPr9Jrg7fRv_aiZkS6UsBp83Bin-mW2e9DrOKZTMmjLFWcMEJ4WqnimTYs7JDi8XKNFP3et33Rf-8G2sF_pf2QX4sgEgG_BDgmBcfuVEw5kk_JUbx6yDXY__OfgIe6-Xag</recordid><startdate>20130704</startdate><enddate>20130704</enddate><creator>Suthanthiran, Manikkam</creator><creator>Schwartz, Joseph E</creator><creator>Ding, 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mRNA Profile and Acute Cellular Rejection in Kidney Allografts</title><author>Suthanthiran, Manikkam ; Schwartz, Joseph E ; Ding, Ruchuang ; Abecassis, Michael ; Dadhania, Darshana ; Samstein, Benjamin ; Knechtle, Stuart J ; Friedewald, John ; Becker, Yolanda T ; Sharma, Vijay K ; Williams, Nikki M ; Chang, Christina S ; Hoang, Christine ; Muthukumar, Thangamani ; August, Phyllis ; Keslar, Karen S ; Fairchild, Robert L ; Hricik, Donald E ; Heeger, Peter S ; Han, Leiya ; Liu, Jun ; Riggs, Michael ; Ikle, David N ; Bridges, Nancy D ; Shaked, Abraham</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c585t-513ceaf9ecda8acb890da685b99de4f1573daa7190b2565c382716145e9b27793</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Acute Disease</topic><topic>Adult</topic><topic>Allografts</topic><topic>Antibodies</topic><topic>Area Under Curve</topic><topic>Biological and medical sciences</topic><topic>Biopsy</topic><topic>Chemokine CXCL10 - genetics</topic><topic>Chemokine CXCL10 - urine</topic><topic>Female</topic><topic>Gene expression</topic><topic>General aspects</topic><topic>Graft rejection</topic><topic>Graft Rejection - diagnosis</topic><topic>Graft Rejection - genetics</topic><topic>Humans</topic><topic>Interferon</topic><topic>Interferon-inducible protein</topic><topic>Interleukin 2</topic><topic>Intracellular Signaling Peptides and Proteins - genetics</topic><topic>Intracellular Signaling Peptides and Proteins - urine</topic><topic>IP-10 protein</topic><topic>Kidney Transplantation</topic><topic>Lymphocytes T</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>mRNA</topic><topic>Prospective Studies</topic><topic>Quality control</topic><topic>Real-Time Polymerase Chain Reaction</topic><topic>RNA, Messenger - urine</topic><topic>RNA, Ribosomal - urine</topic><topic>RNA, Ribosomal, 18S - urine</topic><topic>ROC 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Trials in Organ Transplantation 04 (CTOT-04) Study Investigators</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Urinary-Cell mRNA Profile and Acute Cellular Rejection in Kidney Allografts</atitle><jtitle>The New England journal of medicine</jtitle><addtitle>N Engl J Med</addtitle><date>2013-07-04</date><risdate>2013</risdate><volume>369</volume><issue>1</issue><spage>20</spage><epage>31</epage><pages>20-31</pages><issn>0028-4793</issn><eissn>1533-4406</eissn><coden>NEJMAG</coden><abstract>Noninvasive means for diagnosing acute rejection in kidney transplants are needed. This study prospectively measured mRNA in urinary cells from kidney-allograft recipients. A three-gene signature appeared to be diagnostic and prognostic of acute cellular rejection.
Kidney transplantation is considered the best available treatment for patients with end-stage renal disease (ESRD), but acute rejection, a leading cause of new cases of ESRD, undermines its full benefits.
1
–
3
Acute rejection is diagnosed by means of needle biopsy. Over time, this invasive procedure has become safer, and biopsy interpretation more standardized.
4
Nevertheless, bleeding and subsequent graft loss still occur, and sampling errors and interobserver variability in biopsy reading remain problematic.
5
Repeated biopsies to assess the recipient's status pose challenges, including feasibility and cost.
Immunosuppressive drugs effectively treat acute rejection; a noninvasive means of diagnosing this reversible cause of . . .</abstract><cop>Waltham, MA</cop><pub>Massachusetts Medical Society</pub><pmid>23822777</pmid><doi>10.1056/NEJMoa1215555</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0028-4793 |
| ispartof | The New England journal of medicine, 2013-07, Vol.369 (1), p.20-31 |
| issn | 0028-4793 1533-4406 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; New England Journal of Medicine |
| subjects | Acute Disease Adult Allografts Antibodies Area Under Curve Biological and medical sciences Biopsy Chemokine CXCL10 - genetics Chemokine CXCL10 - urine Female Gene expression General aspects Graft rejection Graft Rejection - diagnosis Graft Rejection - genetics Humans Interferon Interferon-inducible protein Interleukin 2 Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - urine IP-10 protein Kidney Transplantation Lymphocytes T Male Medical sciences Middle Aged mRNA Prospective Studies Quality control Real-Time Polymerase Chain Reaction RNA, Messenger - urine RNA, Ribosomal - urine RNA, Ribosomal, 18S - urine ROC Curve rRNA 18S Sensitivity and Specificity Statistical analysis Transcriptome Transplants & implants Urinary tract Urinary tract infections Urine |
| title | Urinary-Cell mRNA Profile and Acute Cellular Rejection in Kidney Allografts |
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