Alzheimer's Disease Risk Gene, GAB2, is Associated with Regional Brain Volume Differences in 755 Young Healthy Twins
The development of late-onset Alzheimer's disease (LOAD) is under strong genetic control and there is great interest in the genetic variants that confer increased risk. The Alzheimer's disease risk gene, growth factor receptor bound protein 2-associated protein (GAB2), has been shown to pr...
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| Veröffentlicht in: | Twin research and human genetics 2012-06, Vol.15 (3), p.286-295 |
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| creator | Hibar, Derrek P. Jahanshad, Neda Stein, Jason L. Kohannim, Omid Toga, Arthur W. Medland, Sarah E. Hansell, Narelle K. McMahon, Katie L. de Zubicaray, Greig I. Montgomery, Grant W. Martin, Nicholas G. Wright, Margaret J. Thompson, Paul M. |
| description | The development of late-onset Alzheimer's disease (LOAD) is under strong genetic control and there is great interest in the genetic variants that confer increased risk. The Alzheimer's disease risk gene, growth factor receptor bound protein 2-associated protein (GAB2), has been shown to provide a 1.27–1.51 increased odds of developing LOAD for rs7101429 major allele carriers, in case-control analysis. GAB2 is expressed across the brain throughout life, and its role in LOAD pathology is well understood. Recent studies have begun to examine the effect of genetic variation in the GAB2 gene on differences in the brain. However, the effect of GAB2 on the young adult brain has yet to be considered. Here we found a significant association between the GAB2 gene and morphological brain differences in 755 young adult twins (469 females) (M = 23.1, SD = 3.1 years), using a gene-based test with principal components regression (PCReg). Detectable differences in brain morphology are therefore associated with variation in the GAB2 gene, even in young adults, long before the typical age of onset of Alzheimer's disease. |
| doi_str_mv | 10.1017/thg.2012.15 |
| format | Article |
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The Alzheimer's disease risk gene, growth factor receptor bound protein 2-associated protein (GAB2), has been shown to provide a 1.27–1.51 increased odds of developing LOAD for rs7101429 major allele carriers, in case-control analysis. GAB2 is expressed across the brain throughout life, and its role in LOAD pathology is well understood. Recent studies have begun to examine the effect of genetic variation in the GAB2 gene on differences in the brain. However, the effect of GAB2 on the young adult brain has yet to be considered. Here we found a significant association between the GAB2 gene and morphological brain differences in 755 young adult twins (469 females) (M = 23.1, SD = 3.1 years), using a gene-based test with principal components regression (PCReg). Detectable differences in brain morphology are therefore associated with variation in the GAB2 gene, even in young adults, long before the typical age of onset of Alzheimer's disease.</description><identifier>ISSN: 1832-4274</identifier><identifier>EISSN: 1839-2628</identifier><identifier>DOI: 10.1017/thg.2012.15</identifier><identifier>PMID: 22856364</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Adaptor Proteins, Signal Transducing - genetics ; Adult ; Age of Onset ; Alzheimer Disease - genetics ; Alzheimer Disease - pathology ; Analysis of Variance ; Brain - pathology ; Brain morphology ; Diseases ; Diseases in Twins - genetics ; Early detection ; Female ; Genetic Predisposition to Disease ; Genotype ; Growth factor receptor bound protein 2-associated protein (GAB2) ; Humans ; Magnetic Resonance Imaging ; Male ; Organ Size - genetics ; Polymorphism, Single Nucleotide ; Principal Component Analysis ; Risk ; Young Adult</subject><ispartof>Twin research and human genetics, 2012-06, Vol.15 (3), p.286-295</ispartof><rights>Copyright © The Authors 2012</rights><rights>The Authors 2012 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c492t-f80a385d7b102bc75dcafcda7fac5531dbed0300c5cf0c19543aef28620b309a3</citedby><cites>FETCH-LOGICAL-c492t-f80a385d7b102bc75dcafcda7fac5531dbed0300c5cf0c19543aef28620b309a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.cambridge.org/core/product/identifier/S1832427412000151/type/journal_article$$EHTML$$P50$$Gcambridge$$H</linktohtml><link.rule.ids>164,230,314,780,784,885,27924,27925,55628</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22856364$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hibar, Derrek P.</creatorcontrib><creatorcontrib>Jahanshad, Neda</creatorcontrib><creatorcontrib>Stein, Jason L.</creatorcontrib><creatorcontrib>Kohannim, Omid</creatorcontrib><creatorcontrib>Toga, Arthur W.</creatorcontrib><creatorcontrib>Medland, Sarah E.</creatorcontrib><creatorcontrib>Hansell, Narelle K.</creatorcontrib><creatorcontrib>McMahon, Katie L.</creatorcontrib><creatorcontrib>de Zubicaray, Greig I.</creatorcontrib><creatorcontrib>Montgomery, Grant W.</creatorcontrib><creatorcontrib>Martin, Nicholas G.</creatorcontrib><creatorcontrib>Wright, Margaret J.</creatorcontrib><creatorcontrib>Thompson, Paul M.</creatorcontrib><title>Alzheimer's Disease Risk Gene, GAB2, is Associated with Regional Brain Volume Differences in 755 Young Healthy Twins</title><title>Twin research and human genetics</title><addtitle>Twin Res Hum Genet</addtitle><description>The development of late-onset Alzheimer's disease (LOAD) is under strong genetic control and there is great interest in the genetic variants that confer increased risk. The Alzheimer's disease risk gene, growth factor receptor bound protein 2-associated protein (GAB2), has been shown to provide a 1.27–1.51 increased odds of developing LOAD for rs7101429 major allele carriers, in case-control analysis. GAB2 is expressed across the brain throughout life, and its role in LOAD pathology is well understood. Recent studies have begun to examine the effect of genetic variation in the GAB2 gene on differences in the brain. However, the effect of GAB2 on the young adult brain has yet to be considered. Here we found a significant association between the GAB2 gene and morphological brain differences in 755 young adult twins (469 females) (M = 23.1, SD = 3.1 years), using a gene-based test with principal components regression (PCReg). Detectable differences in brain morphology are therefore associated with variation in the GAB2 gene, even in young adults, long before the typical age of onset of Alzheimer's disease.</description><subject>Adaptor Proteins, Signal Transducing - genetics</subject><subject>Adult</subject><subject>Age of Onset</subject><subject>Alzheimer Disease - genetics</subject><subject>Alzheimer Disease - pathology</subject><subject>Analysis of Variance</subject><subject>Brain - pathology</subject><subject>Brain morphology</subject><subject>Diseases</subject><subject>Diseases in Twins - genetics</subject><subject>Early detection</subject><subject>Female</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotype</subject><subject>Growth factor receptor bound protein 2-associated protein (GAB2)</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Organ Size - genetics</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Principal Component Analysis</subject><subject>Risk</subject><subject>Young Adult</subject><issn>1832-4274</issn><issn>1839-2628</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkUtv1DAURiNERUthxR55BxLN4EecxwZpWugUqRKoKkisrBvnJvHgxIPtUJVfT-ZBBRIrW75H3_3kkyQvGF0wyoq3se8WnDK-YPJRcsJKUaU85-Xj3Z2nGS-y4-RpCGtKRcEq-iQ55ryUucizkyQu7a8ezYD-VSDvTUAISG5M-E5WOOIZWS3P-RkxgSxDcNpAxIbcmdiTG-yMG8GScw9mJF-dnQacE9oWPY4aA5lfCynJNzeNHblCsLG_J7d3ZgzPkqMWbMDnh_M0-XL54fbiKr3-tPp4sbxOdVbxmLYlBVHKpqgZ5bUuZKOh1Q0ULWgpBWtqbKigVEvdUs0qmQnAlpc5p7WgFYjT5N0-dzPVAzYax-jBqo03A_h75cCofyej6VXnfipRlFIUxRzw-hDg3Y8JQ1SDCRqthRHdFBSjgjFZCSZm9M0e1d6F4LF9WMOo2npSsye19aSYnOmXfzd7YP-ImYHPe8APJirtrEUd5w8Pa4hBzZq87pUZW7ebO9-pxhkF9baTEoLlyqCFDew2MpHJbWR6aAhD7U3ToVq7yc8Ow387_gaTQ7rG</recordid><startdate>201206</startdate><enddate>201206</enddate><creator>Hibar, Derrek P.</creator><creator>Jahanshad, Neda</creator><creator>Stein, Jason L.</creator><creator>Kohannim, Omid</creator><creator>Toga, Arthur W.</creator><creator>Medland, Sarah E.</creator><creator>Hansell, Narelle K.</creator><creator>McMahon, Katie L.</creator><creator>de Zubicaray, Greig I.</creator><creator>Montgomery, Grant W.</creator><creator>Martin, Nicholas G.</creator><creator>Wright, Margaret J.</creator><creator>Thompson, Paul M.</creator><general>Cambridge University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201206</creationdate><title>Alzheimer's Disease Risk Gene, GAB2, is Associated with Regional Brain Volume Differences in 755 Young Healthy Twins</title><author>Hibar, Derrek P. ; 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The Alzheimer's disease risk gene, growth factor receptor bound protein 2-associated protein (GAB2), has been shown to provide a 1.27–1.51 increased odds of developing LOAD for rs7101429 major allele carriers, in case-control analysis. GAB2 is expressed across the brain throughout life, and its role in LOAD pathology is well understood. Recent studies have begun to examine the effect of genetic variation in the GAB2 gene on differences in the brain. However, the effect of GAB2 on the young adult brain has yet to be considered. Here we found a significant association between the GAB2 gene and morphological brain differences in 755 young adult twins (469 females) (M = 23.1, SD = 3.1 years), using a gene-based test with principal components regression (PCReg). Detectable differences in brain morphology are therefore associated with variation in the GAB2 gene, even in young adults, long before the typical age of onset of Alzheimer's disease.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>22856364</pmid><doi>10.1017/thg.2012.15</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Twin research and human genetics, 2012-06, Vol.15 (3), p.286-295 |
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| subjects | Adaptor Proteins, Signal Transducing - genetics Adult Age of Onset Alzheimer Disease - genetics Alzheimer Disease - pathology Analysis of Variance Brain - pathology Brain morphology Diseases Diseases in Twins - genetics Early detection Female Genetic Predisposition to Disease Genotype Growth factor receptor bound protein 2-associated protein (GAB2) Humans Magnetic Resonance Imaging Male Organ Size - genetics Polymorphism, Single Nucleotide Principal Component Analysis Risk Young Adult |
| title | Alzheimer's Disease Risk Gene, GAB2, is Associated with Regional Brain Volume Differences in 755 Young Healthy Twins |
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