TNFα reverse signaling promotes sympathetic axon growth and target innervation

The authors show that the TNFα receptor, expressed on peripheral target tissue, can act as a ligand to induce reverse TNFα signaling in superior cervical ganglion neurons, promoting neurite growth and branching. This reverse signaling is crucial in establishing sympathetic innervation. Reverse signa...

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Veröffentlicht in:	Nature neuroscience 2013-07, Vol.16 (7), p.865-873
Hauptverfasser:	Kisiswa, Lilian, Osório, Catarina, Erice, Clara, Vizard, Thomas, Wyatt, Sean, Davies, Alun M
Format:	Artikel
Sprache:	eng
Schlagworte:	631/378/2571 ADAM Proteins - pharmacology ADAM17 Protein Animal Genetics and Genomics Animals Animals, Newborn Axons - physiology Behavioral Sciences Biological Techniques Biomedicine Calcium - metabolism Cells, Cultured Cellular signal transduction Chelating Agents - pharmacology Dose-Response Relationship, Drug Egtazic Acid - analogs & derivatives Egtazic Acid - pharmacology Embryo, Mammalian Gene Expression Regulation, Developmental - drug effects Gene Expression Regulation, Developmental - genetics Genetic aspects Growth Mice Mice, Transgenic Nerve Fibers - physiology Nerve Growth Factor - pharmacology Neurobiology Neurons Neurons - cytology Neurosciences Properties Receptors, Tumor Necrosis Factor, Type I - deficiency Receptors, Tumor Necrosis Factor, Type I - metabolism RNA, Messenger - metabolism Signal Transduction - drug effects Signal Transduction - genetics Signal Transduction - physiology Superior Cervical Ganglion - cytology Sympathetic Nervous System - cytology Sympathetic Nervous System - embryology Sympathetic Nervous System - growth & development Tumor necrosis factor Tumor Necrosis Factor-alpha - genetics Tumor Necrosis Factor-alpha - metabolism Tyrosine 3-Monooxygenase - metabolism
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