The transcription factor Engrailed-2 guides retinal axons

Engrailed-2 (En-2), a homeodomain transcription factor, is expressed in a caudal-to-rostral gradient in the developing midbrain, where it has an instructive role in patterning the optic tectum—the target of topographic retinal input 1 , 2 . In addition to its well-known role in regulating gene expre...

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Veröffentlicht in:	Nature 2005-11, Vol.438 (7064), p.94-98
Hauptverfasser:	Brunet, Isabelle, Weinl, Christine, Piper, Michael, Trembleau, Alain, Volovitch, Michel, Harris, William, Prochiantz, Alain, Holt, Christine
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Axons - drug effects Axons - metabolism Biological and medical sciences Deoxyribonucleic acid DNA Endocytosis Eye and associated structures. Visual pathways and centers. Vision Female Freshwater Fundamental and applied biological sciences. Psychology Growth Cones - drug effects Homeodomain Proteins - metabolism Homeodomain Proteins - pharmacology Humanities and Social Sciences letter multidisciplinary Nerve Tissue Proteins - metabolism Nerve Tissue Proteins - pharmacology Neurology Neurons Nose - cytology Nose - drug effects Nose - innervation Phosphorylation - drug effects Protein Biosynthesis - drug effects Protein synthesis Protein Transport Retina Retina - cytology Retina - drug effects Retina - embryology Retina - metabolism Retinal Ganglion Cells - cytology Retinal Ganglion Cells - drug effects Retinal Ganglion Cells - metabolism Science Science (multidisciplinary) Topographic mapping Transcription Factors - metabolism Transcription Factors - pharmacology Vertebrates: nervous system and sense organs Vision, Ocular - drug effects Vision, Ocular - physiology Xenopus Xenopus - embryology
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