PDZ-RhoGEF is essential for CXCR4-driven breast tumor cell motility through spatial regulation of RhoA

The CXCL12-CXCR4 chemokine signaling pathway is a well-established driver of cancer progression. One key process promoted by CXCR4 stimulation is tumor cell motility; however, the specific signaling pathways leading to migration remain poorly understood. Previously, we have shown that CXCL12 stimula...

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Veröffentlicht in:	Journal of cell science 2013-10, Vol.126 (Pt 19), p.4514-4526
Hauptverfasser:	Struckhoff, Amanda P, Rana, Manish K, Kher, Swapnil S, Burow, Matt E, Hagan, Joseph L, Del Valle, Luis, Worthylake, Rebecca A
Format:	Artikel
Sprache:	eng
Schlagworte:	Breast Neoplasms - metabolism Breast Neoplasms - pathology Cell Line, Tumor Cell Movement - physiology Female Humans MCF-7 Cells PDZ Domains Phosphorylation Receptors, CXCR4 - metabolism Rho Guanine Nucleotide Exchange Factors - metabolism rhoA GTP-Binding Protein - metabolism Signal Transduction
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