Kinetics of Avibactam Inhibition against Class A, C, and D β-Lactamases

Avibactam is a non-β-lactam β-lactamase inhibitor with a spectrum of activity that includes β-lactamase enzymes of classes A, C, and selected D examples. In this work acylation and deacylation rates were measured against the clinically important enzymes CTX-M-15, KPC-2, Enterobacter cloacae AmpC, Ps...

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Veröffentlicht in:	The Journal of biological chemistry 2013-09, Vol.288 (39), p.27960-27971
Hauptverfasser:	Ehmann, David E., Jahić, Haris, Ross, Philip L., Gu, Rong-Fang, Hu, Jun, Durand-Réville, Thomas F., Lahiri, Sushmita, Thresher, Jason, Livchak, Stephania, Gao, Ning, Palmer, Tiffany, Walkup, Grant K., Fisher, Stewart L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - chemistry Antibiotics Azabicyclo Compounds - chemistry beta-Lactamases - chemistry Drug Discovery Drug Resistance, Bacterial Enterobacter cloacae - metabolism Enzyme Inhibitors Enzyme Inhibitors - chemistry Enzyme Kinetics Enzymology Escherichia coli - drug effects Escherichia coli - metabolism Hydrolysis Kinetics Magnetic Resonance Spectroscopy Mass Spectrometry Mass Spectrometry (MS) Microbial Sensitivity Tests Plasmids - metabolism Pseudomonas aeruginosa - metabolism Time Factors
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