Nicotinamide Adenine Dinucleotide-induced Multimerization of the Co-repressor CtBP1 Relies on a Switching Tryptophan

The transcriptional co-repressor C-terminal binding protein (CtBP) interacts with a number of repressor proteins and chromatin modifying enzymes. How the biochemical properties including binding of dinucleotide, oligomerization, and dehydrogenase domains of CtBP1 direct the assembly of a functional...

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Veröffentlicht in:	The Journal of biological chemistry 2013-09, Vol.288 (39), p.27836-27848
Hauptverfasser:	Madison, Dana L., Wirz, Jacqueline A., Siess, Don, Lundblad, James R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcohol Oxidoreductases - chemistry Amino Acid Motifs Binding Sites C-terminal-binding Protein Cell Biology Cell Line, Tumor Chromatography, Gel Corepressor Transcription Cross-Linking Reagents - pharmacology Dehydrogenase DNA-Binding Proteins - chemistry Fluorescence Resonance Energy Transfer Gene Expression Regulation, Neoplastic Humans Mutagenesis NAD NAD - metabolism Nucleotides - chemistry Protein Binding Protein Multimerization Protein Structure, Tertiary Protein-Protein Interactions Transcription Tryptophan - chemistry Two-Hybrid System Techniques
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