miR-29b represses intestinal mucosal growth by inhibiting translation of cyclin-dependent kinase 2

The epithelium of the intestinal mucosa is a rapidly self-renewing tissue in the body, and defects in the renewal process occur commonly in various disorders. microRNAs (miRNAs) posttranscriptionally regulate gene expression and are implicated in many aspects of cellular physiology. Here we investig...

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Veröffentlicht in:	Molecular biology of the cell 2013-10, Vol.24 (19), p.3038-3046
Hauptverfasser:	Xiao, Lan, Rao, Jaladanki N, Zou, Tongtong, Liu, Lan, Cao, Shan, Martindale, Jennifer L, Su, Weijie, Chung, Hee Kyoung, Gorospe, Myriam, Wang, Jian-Ying
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line Cyclin-Dependent Kinase 2 - antagonists & inhibitors Cyclin-Dependent Kinase 2 - genetics Gene Expression Regulation, Developmental Humans Intestinal Mucosa - growth & development Intestinal Mucosa - metabolism Mice MicroRNAs - genetics MicroRNAs - metabolism Protein Biosynthesis - genetics Rats
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