KIR‐HLA‐A and B alleles of the Bw4 epitope against HIV infection in discordant heterosexual couples in Chaco Argentina
Summary Activating and inhibitory killer immunoglobulin‐like receptors (KIR) and their ligands HLA‐Bw4 (loci A and B) were studied by way of establishing whether they can contribute to protection against HIV‐1 infection in highly exposed and persistently seronegative (HESN) patients. Twenty‐three HI...
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| Veröffentlicht in: | Immunology 2013-10, Vol.140 (2), p.273-279 |
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| creator | Habegger de Sorrentino, Alicia Sinchi, Jessica L. Marinic, Karina López, Rosana Iliovich, Ernesto |
| description | Summary
Activating and inhibitory killer immunoglobulin‐like receptors (KIR) and their ligands HLA‐Bw4 (loci A and B) were studied by way of establishing whether they can contribute to protection against HIV‐1 infection in highly exposed and persistently seronegative (HESN) patients. Twenty‐three HIV‐1 serodiscordant heterosexual couples, 100 HIV‐1+ patients and 200 healthy individuals were included in this retrospective case–control study. HLA typing was performed by means of PCR followed by sequence‐specific oligonucleotide probe reverse hybridization. KIR3DL1 and KIR3DS1 were studied by PCR sequence‐specific primers. The frequency of KIR3DS1(3DS1/3DL1)‐Bw4 combination was significantly higher in HESN patients versus the discordant couples (P = 0·0003) and HIV‐1+ patients (P = 0·0001). Conversely, the KIR3DL1/KIR3DL1 homozygosity was significantly decreased in HESN patients versus the discordant couples (P = 0·00003), and HIV‐1+ patients (P = 0·00066). The frequency of HLA‐A*32 and HLA‐B*44 was higher in HESN versus their discordant couples (P = 0·009; P = 0·049), and HIV‐1+ patients (P = 0·00002; P = 0·0001). This had greater significance in combination with KIR3DS1 (3DS1/3DL1). KIR3DS1(3DS1/3DL1) could have a greater effect on protection against HIV‐1 infection in HESN patients when bound to a specific HLA allele, in this case HLA‐A*32 and HLA‐B*44, both Bw4 alleles. The differences probably arise both in the HLA alleles and in the subtypes of KIR receptors depending on the ethnic group studied. |
| doi_str_mv | 10.1111/imm.12137 |
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Activating and inhibitory killer immunoglobulin‐like receptors (KIR) and their ligands HLA‐Bw4 (loci A and B) were studied by way of establishing whether they can contribute to protection against HIV‐1 infection in highly exposed and persistently seronegative (HESN) patients. Twenty‐three HIV‐1 serodiscordant heterosexual couples, 100 HIV‐1+ patients and 200 healthy individuals were included in this retrospective case–control study. HLA typing was performed by means of PCR followed by sequence‐specific oligonucleotide probe reverse hybridization. KIR3DL1 and KIR3DS1 were studied by PCR sequence‐specific primers. The frequency of KIR3DS1(3DS1/3DL1)‐Bw4 combination was significantly higher in HESN patients versus the discordant couples (P = 0·0003) and HIV‐1+ patients (P = 0·0001). Conversely, the KIR3DL1/KIR3DL1 homozygosity was significantly decreased in HESN patients versus the discordant couples (P = 0·00003), and HIV‐1+ patients (P = 0·00066). The frequency of HLA‐A*32 and HLA‐B*44 was higher in HESN versus their discordant couples (P = 0·009; P = 0·049), and HIV‐1+ patients (P = 0·00002; P = 0·0001). This had greater significance in combination with KIR3DS1 (3DS1/3DL1). KIR3DS1(3DS1/3DL1) could have a greater effect on protection against HIV‐1 infection in HESN patients when bound to a specific HLA allele, in this case HLA‐A*32 and HLA‐B*44, both Bw4 alleles. The differences probably arise both in the HLA alleles and in the subtypes of KIR receptors depending on the ethnic group studied.</description><identifier>ISSN: 0019-2805</identifier><identifier>EISSN: 1365-2567</identifier><identifier>DOI: 10.1111/imm.12137</identifier><identifier>PMID: 23789883</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Adult ; Alleles ; Argentina ; Epitopes ; Female ; Genetic Predisposition to Disease - genetics ; Genotype ; Heterosexuality ; HIV Infections - genetics ; HIV‐1 ; HLA, human leucocyte antigen ; HLA-A Antigens - genetics ; HLA-B Antigens - genetics ; Human immunodeficiency virus 1 ; Humans ; killer immunoglobulin‐like receptor ; KIR3DL1 ; KIR3DS1 ; Male ; Original ; Receptors, KIR - genetics</subject><ispartof>Immunology, 2013-10, Vol.140 (2), p.273-279</ispartof><rights>2013 John Wiley & Sons Ltd</rights><rights>2013 John Wiley & Sons Ltd.</rights><rights>Copyright © 2013 John Wiley & Sons Ltd</rights><rights>Copyright © 2013 John Wiley & Sons Ltd 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3784173/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3784173/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,725,778,782,883,1414,1430,27907,27908,45557,45558,46392,46816,53774,53776</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23789883$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Habegger de Sorrentino, Alicia</creatorcontrib><creatorcontrib>Sinchi, Jessica L.</creatorcontrib><creatorcontrib>Marinic, Karina</creatorcontrib><creatorcontrib>López, Rosana</creatorcontrib><creatorcontrib>Iliovich, Ernesto</creatorcontrib><title>KIR‐HLA‐A and B alleles of the Bw4 epitope against HIV infection in discordant heterosexual couples in Chaco Argentina</title><title>Immunology</title><addtitle>Immunology</addtitle><description>Summary
Activating and inhibitory killer immunoglobulin‐like receptors (KIR) and their ligands HLA‐Bw4 (loci A and B) were studied by way of establishing whether they can contribute to protection against HIV‐1 infection in highly exposed and persistently seronegative (HESN) patients. Twenty‐three HIV‐1 serodiscordant heterosexual couples, 100 HIV‐1+ patients and 200 healthy individuals were included in this retrospective case–control study. HLA typing was performed by means of PCR followed by sequence‐specific oligonucleotide probe reverse hybridization. KIR3DL1 and KIR3DS1 were studied by PCR sequence‐specific primers. The frequency of KIR3DS1(3DS1/3DL1)‐Bw4 combination was significantly higher in HESN patients versus the discordant couples (P = 0·0003) and HIV‐1+ patients (P = 0·0001). Conversely, the KIR3DL1/KIR3DL1 homozygosity was significantly decreased in HESN patients versus the discordant couples (P = 0·00003), and HIV‐1+ patients (P = 0·00066). The frequency of HLA‐A*32 and HLA‐B*44 was higher in HESN versus their discordant couples (P = 0·009; P = 0·049), and HIV‐1+ patients (P = 0·00002; P = 0·0001). This had greater significance in combination with KIR3DS1 (3DS1/3DL1). KIR3DS1(3DS1/3DL1) could have a greater effect on protection against HIV‐1 infection in HESN patients when bound to a specific HLA allele, in this case HLA‐A*32 and HLA‐B*44, both Bw4 alleles. The differences probably arise both in the HLA alleles and in the subtypes of KIR receptors depending on the ethnic group studied.</description><subject>Adult</subject><subject>Alleles</subject><subject>Argentina</subject><subject>Epitopes</subject><subject>Female</subject><subject>Genetic Predisposition to Disease - genetics</subject><subject>Genotype</subject><subject>Heterosexuality</subject><subject>HIV Infections - genetics</subject><subject>HIV‐1</subject><subject>HLA, human leucocyte antigen</subject><subject>HLA-A Antigens - genetics</subject><subject>HLA-B Antigens - genetics</subject><subject>Human immunodeficiency virus 1</subject><subject>Humans</subject><subject>killer immunoglobulin‐like receptor</subject><subject>KIR3DL1</subject><subject>KIR3DS1</subject><subject>Male</subject><subject>Original</subject><subject>Receptors, KIR - genetics</subject><issn>0019-2805</issn><issn>1365-2567</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkktuFDEQhi0EIkNgwQWQJTZsOvGz7d4gTUbAjJgICQFbq9JdnnHUbTf9IIQVR-CMnATnQQSs8MIuqz79VS7_hDzl7IjndRy67ogLLs09suCy1IXQpblPFozxqhCW6QPyaBzP81UyrR-SAyGNrayVC_Lt7eb9z-8_1ttl3pcUYkNPKLQttjjS5Om0R3pyoSj2YUo9UthBiONE15tPNESP9RRSzBFtwlinoYE40T1OOKQRv87Q0jrN_ZVWRlZ7qBNdDjuMU4jwmDzw0I745PY8JB9fv_qwWhfbd282q-W26BUTpijBW2C2RiNZyRrTWGu0roHX2mvFuBdWK1WjapgCfVZ6Y5oKsOLWa2-kl4fk5Y1uP5912NS5-gCt64fQwXDpEgT3dyaGvdulLy4PSXEjs8CLW4EhfZ5xnFyXH4ttCxHTPDquZCW45br6H1SUvCorm9Hn_6DnaR5inoTjWhjGpK5Mpp792fxd179_MAPHN8BFaPHyLs-Zu7KGy9Zw19Zwm9PT60D-AvZlrJo</recordid><startdate>201310</startdate><enddate>201310</enddate><creator>Habegger de Sorrentino, Alicia</creator><creator>Sinchi, Jessica L.</creator><creator>Marinic, Karina</creator><creator>López, Rosana</creator><creator>Iliovich, Ernesto</creator><general>Wiley Subscription Services, Inc</general><general>Blackwell Science Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7QL</scope><scope>7QR</scope><scope>7T5</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201310</creationdate><title>KIR‐HLA‐A and B alleles of the Bw4 epitope against HIV infection in discordant heterosexual couples in Chaco Argentina</title><author>Habegger de Sorrentino, Alicia ; Sinchi, Jessica L. ; Marinic, Karina ; López, Rosana ; Iliovich, Ernesto</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p4027-6af8a08ce73060d7d88755ca1c5f5401f28544ce4d04a5b6f77d9ae918f5f73f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Alleles</topic><topic>Argentina</topic><topic>Epitopes</topic><topic>Female</topic><topic>Genetic Predisposition to Disease - genetics</topic><topic>Genotype</topic><topic>Heterosexuality</topic><topic>HIV Infections - genetics</topic><topic>HIV‐1</topic><topic>HLA, human leucocyte antigen</topic><topic>HLA-A Antigens - genetics</topic><topic>HLA-B Antigens - genetics</topic><topic>Human immunodeficiency virus 1</topic><topic>Humans</topic><topic>killer immunoglobulin‐like receptor</topic><topic>KIR3DL1</topic><topic>KIR3DS1</topic><topic>Male</topic><topic>Original</topic><topic>Receptors, KIR - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Habegger de Sorrentino, Alicia</creatorcontrib><creatorcontrib>Sinchi, Jessica L.</creatorcontrib><creatorcontrib>Marinic, Karina</creatorcontrib><creatorcontrib>López, Rosana</creatorcontrib><creatorcontrib>Iliovich, Ernesto</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Chemoreception Abstracts</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Habegger de Sorrentino, Alicia</au><au>Sinchi, Jessica L.</au><au>Marinic, Karina</au><au>López, Rosana</au><au>Iliovich, Ernesto</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>KIR‐HLA‐A and B alleles of the Bw4 epitope against HIV infection in discordant heterosexual couples in Chaco Argentina</atitle><jtitle>Immunology</jtitle><addtitle>Immunology</addtitle><date>2013-10</date><risdate>2013</risdate><volume>140</volume><issue>2</issue><spage>273</spage><epage>279</epage><pages>273-279</pages><issn>0019-2805</issn><eissn>1365-2567</eissn><abstract>Summary
Activating and inhibitory killer immunoglobulin‐like receptors (KIR) and their ligands HLA‐Bw4 (loci A and B) were studied by way of establishing whether they can contribute to protection against HIV‐1 infection in highly exposed and persistently seronegative (HESN) patients. Twenty‐three HIV‐1 serodiscordant heterosexual couples, 100 HIV‐1+ patients and 200 healthy individuals were included in this retrospective case–control study. HLA typing was performed by means of PCR followed by sequence‐specific oligonucleotide probe reverse hybridization. KIR3DL1 and KIR3DS1 were studied by PCR sequence‐specific primers. The frequency of KIR3DS1(3DS1/3DL1)‐Bw4 combination was significantly higher in HESN patients versus the discordant couples (P = 0·0003) and HIV‐1+ patients (P = 0·0001). Conversely, the KIR3DL1/KIR3DL1 homozygosity was significantly decreased in HESN patients versus the discordant couples (P = 0·00003), and HIV‐1+ patients (P = 0·00066). The frequency of HLA‐A*32 and HLA‐B*44 was higher in HESN versus their discordant couples (P = 0·009; P = 0·049), and HIV‐1+ patients (P = 0·00002; P = 0·0001). This had greater significance in combination with KIR3DS1 (3DS1/3DL1). KIR3DS1(3DS1/3DL1) could have a greater effect on protection against HIV‐1 infection in HESN patients when bound to a specific HLA allele, in this case HLA‐A*32 and HLA‐B*44, both Bw4 alleles. The differences probably arise both in the HLA alleles and in the subtypes of KIR receptors depending on the ethnic group studied.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>23789883</pmid><doi>10.1111/imm.12137</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Alleles Argentina Epitopes Female Genetic Predisposition to Disease - genetics Genotype Heterosexuality HIV Infections - genetics HIV‐1 HLA, human leucocyte antigen HLA-A Antigens - genetics HLA-B Antigens - genetics Human immunodeficiency virus 1 Humans killer immunoglobulin‐like receptor KIR3DL1 KIR3DS1 Male Original Receptors, KIR - genetics |
| title | KIR‐HLA‐A and B alleles of the Bw4 epitope against HIV infection in discordant heterosexual couples in Chaco Argentina |
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