Kinase AKT controls innate immune cell development and function
Summary The critical roles of kinase AKT in tumour cell proliferation, apoptosis and protein synthesis have been widely recognized. But AKT also plays an important role in immune modulation. Recent studies have confirmed that kinase AKT can regulate the development and functions of innate immune cel...
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| Veröffentlicht in: | Immunology 2013-10, Vol.140 (2), p.143-152 |
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| container_end_page | 152 |
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| container_issue | 2 |
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| container_title | Immunology |
| container_volume | 140 |
| creator | Zhang, Yan Wang, Xiao Yang, Hui Liu, Huanrong Lu, Yun Han, Limei Liu, Guangwei |
| description | Summary
The critical roles of kinase AKT in tumour cell proliferation, apoptosis and protein synthesis have been widely recognized. But AKT also plays an important role in immune modulation. Recent studies have confirmed that kinase AKT can regulate the development and functions of innate immune cells (neutrophil, macrophage and dendritic cell). Studies have shown that different isoforms of kinase AKT have different effects in regulating immunity‐related diseases, mainly through the mammalian target of rapamycin‐dependent or ‐independent pathways. The purpose of this review is to illustrate the immune modulating effects of kinase AKT on innate immune cell development, survival and function. |
| doi_str_mv | 10.1111/imm.12123 |
| format | Article |
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The critical roles of kinase AKT in tumour cell proliferation, apoptosis and protein synthesis have been widely recognized. But AKT also plays an important role in immune modulation. Recent studies have confirmed that kinase AKT can regulate the development and functions of innate immune cells (neutrophil, macrophage and dendritic cell). Studies have shown that different isoforms of kinase AKT have different effects in regulating immunity‐related diseases, mainly through the mammalian target of rapamycin‐dependent or ‐independent pathways. The purpose of this review is to illustrate the immune modulating effects of kinase AKT on innate immune cell development, survival and function.</description><identifier>ISSN: 0019-2805</identifier><identifier>EISSN: 1365-2567</identifier><identifier>DOI: 10.1111/imm.12123</identifier><identifier>PMID: 23692658</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Animals ; Cell Differentiation ; homeostasis ; Humans ; Immune system ; immunity ; Immunity, Innate - physiology ; innate immunity ; kinase AKT ; Kinases ; Medical research ; modulation ; molecular mechanisms ; Proto-Oncogene Proteins c-akt - immunology ; Review ; Signal Transduction - immunology</subject><ispartof>Immunology, 2013-10, Vol.140 (2), p.143-152</ispartof><rights>2013 John Wiley & Sons Ltd</rights><rights>2013 John Wiley & Sons Ltd.</rights><rights>Copyright © 2013 John Wiley & Sons Ltd</rights><rights>Copyright © 2013 John Wiley & Sons Ltd 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4763-b07ae1927260274be99f9e75731820e1dc730806c1cc3b4c65a8932c5d87aa303</citedby><cites>FETCH-LOGICAL-c4763-b07ae1927260274be99f9e75731820e1dc730806c1cc3b4c65a8932c5d87aa303</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3784161/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3784161/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,1416,1432,27923,27924,45573,45574,46408,46832,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23692658$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Yan</creatorcontrib><creatorcontrib>Wang, Xiao</creatorcontrib><creatorcontrib>Yang, Hui</creatorcontrib><creatorcontrib>Liu, Huanrong</creatorcontrib><creatorcontrib>Lu, Yun</creatorcontrib><creatorcontrib>Han, Limei</creatorcontrib><creatorcontrib>Liu, Guangwei</creatorcontrib><title>Kinase AKT controls innate immune cell development and function</title><title>Immunology</title><addtitle>Immunology</addtitle><description>Summary
The critical roles of kinase AKT in tumour cell proliferation, apoptosis and protein synthesis have been widely recognized. But AKT also plays an important role in immune modulation. Recent studies have confirmed that kinase AKT can regulate the development and functions of innate immune cells (neutrophil, macrophage and dendritic cell). Studies have shown that different isoforms of kinase AKT have different effects in regulating immunity‐related diseases, mainly through the mammalian target of rapamycin‐dependent or ‐independent pathways. The purpose of this review is to illustrate the immune modulating effects of kinase AKT on innate immune cell development, survival and function.</description><subject>Animals</subject><subject>Cell Differentiation</subject><subject>homeostasis</subject><subject>Humans</subject><subject>Immune system</subject><subject>immunity</subject><subject>Immunity, Innate - physiology</subject><subject>innate immunity</subject><subject>kinase AKT</subject><subject>Kinases</subject><subject>Medical research</subject><subject>modulation</subject><subject>molecular mechanisms</subject><subject>Proto-Oncogene Proteins c-akt - immunology</subject><subject>Review</subject><subject>Signal Transduction - immunology</subject><issn>0019-2805</issn><issn>1365-2567</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc9LHTEQx0Ox6NN66D9QFrzUw2om2fy6VETUikov9hzysvM0spu8bnZf8b83-qy0BcG5hCEfPszMl5DPQA-g1GHo-wNgwPgHMgMuRc2EVBtkRimYmmkqtsh2zvel5VSITbLFuDRMCj0jR5chuozV8eVN5VMch9TlKsToRqyKdopYeey6qsUVdmnZYxwrF9tqMUU_hhQ_kY8L12XcfXl3yM-z05uT7_XVj_OLk-Or2jdK8npOlUMwTDFJmWrmaMzCoBKKg2YUofWKU02lB-_5vPFSOG0486LVyjlO-Q75tvYup3mPrS9zDK6zyyH0bniwyQX7708Md_Y2rSxXugEJRfD1RTCkXxPm0fYhP63mIqYpW2i4YaCBvgtlkoF5tu79h96naYjlEhYEU5Ry4LpQ-2vKDynnARevcwO1Twnacmr7nGBhv_y96Cv5J7ICHK6B36HDh7dN9uL6eq18BLW3ozQ</recordid><startdate>201310</startdate><enddate>201310</enddate><creator>Zhang, Yan</creator><creator>Wang, Xiao</creator><creator>Yang, Hui</creator><creator>Liu, Huanrong</creator><creator>Lu, Yun</creator><creator>Han, Limei</creator><creator>Liu, Guangwei</creator><general>Wiley Subscription Services, Inc</general><general>Blackwell Science Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QR</scope><scope>7T5</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201310</creationdate><title>Kinase AKT controls innate immune cell development and function</title><author>Zhang, Yan ; Wang, Xiao ; Yang, Hui ; Liu, Huanrong ; Lu, Yun ; Han, Limei ; Liu, Guangwei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4763-b07ae1927260274be99f9e75731820e1dc730806c1cc3b4c65a8932c5d87aa303</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Animals</topic><topic>Cell Differentiation</topic><topic>homeostasis</topic><topic>Humans</topic><topic>Immune system</topic><topic>immunity</topic><topic>Immunity, Innate - physiology</topic><topic>innate immunity</topic><topic>kinase AKT</topic><topic>Kinases</topic><topic>Medical research</topic><topic>modulation</topic><topic>molecular mechanisms</topic><topic>Proto-Oncogene Proteins c-akt - immunology</topic><topic>Review</topic><topic>Signal Transduction - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Yan</creatorcontrib><creatorcontrib>Wang, Xiao</creatorcontrib><creatorcontrib>Yang, Hui</creatorcontrib><creatorcontrib>Liu, Huanrong</creatorcontrib><creatorcontrib>Lu, Yun</creatorcontrib><creatorcontrib>Han, Limei</creatorcontrib><creatorcontrib>Liu, Guangwei</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Chemoreception Abstracts</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Yan</au><au>Wang, Xiao</au><au>Yang, Hui</au><au>Liu, Huanrong</au><au>Lu, Yun</au><au>Han, Limei</au><au>Liu, Guangwei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Kinase AKT controls innate immune cell development and function</atitle><jtitle>Immunology</jtitle><addtitle>Immunology</addtitle><date>2013-10</date><risdate>2013</risdate><volume>140</volume><issue>2</issue><spage>143</spage><epage>152</epage><pages>143-152</pages><issn>0019-2805</issn><eissn>1365-2567</eissn><abstract>Summary
The critical roles of kinase AKT in tumour cell proliferation, apoptosis and protein synthesis have been widely recognized. But AKT also plays an important role in immune modulation. Recent studies have confirmed that kinase AKT can regulate the development and functions of innate immune cells (neutrophil, macrophage and dendritic cell). Studies have shown that different isoforms of kinase AKT have different effects in regulating immunity‐related diseases, mainly through the mammalian target of rapamycin‐dependent or ‐independent pathways. The purpose of this review is to illustrate the immune modulating effects of kinase AKT on innate immune cell development, survival and function.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>23692658</pmid><doi>10.1111/imm.12123</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Immunology, 2013-10, Vol.140 (2), p.143-152 |
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| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Wiley Free Content; IngentaConnect Free/Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Animals Cell Differentiation homeostasis Humans Immune system immunity Immunity, Innate - physiology innate immunity kinase AKT Kinases Medical research modulation molecular mechanisms Proto-Oncogene Proteins c-akt - immunology Review Signal Transduction - immunology |
| title | Kinase AKT controls innate immune cell development and function |
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