DHHC8-dependent PICK1 palmitoylation is required for induction of cerebellar long-term synaptic depression

The palmitoyl acyltransferase (PAT) DHHC8 is implicated in synaptic regulation but few DHHC8 substrates are known. Here we report that DHHC8 binds and palmitoylates the PDZ domain-containing protein PICK1 at a cysteine residue that is essential for long-term synaptic depression (LTD) in cultured mou...

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Veröffentlicht in:	The Journal of neuroscience 2013-09, Vol.33 (39), p.15401-15407
Hauptverfasser:	Thomas, Gareth M, Hayashi, Takashi, Huganir, Richard L, Linden, David J
Format:	Artikel
Sprache:	eng
Schlagworte:	Acyltransferases - genetics Acyltransferases - metabolism Animals Brief Communications Carrier Proteins - chemistry Carrier Proteins - genetics Carrier Proteins - metabolism Cells, Cultured Cerebellum - cytology Cerebellum - metabolism Cerebellum - physiology Cysteine - metabolism Lipoylation Long-Term Synaptic Depression Membrane Proteins - genetics Membrane Proteins - metabolism Mice Mice, Knockout Nuclear Proteins - chemistry Nuclear Proteins - genetics Nuclear Proteins - metabolism PDZ Domains Purkinje Cells - metabolism
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