Combined Heart Rate- and Accelerometer-Assessed Physical Activity Energy Expenditure and Associations With Glucose Homeostasis Markers in a Population at High Risk of Developing Diabetes: The ADDITION-PRO study
Regular physical activity (PA) reduces the risk of developing type 2 diabetes, and different subtypes of dysglycemia have shown different associations with PA. To better understand the associations of PA and glucose homeostasis, we examined the association of objectively measured PA energy expenditu...
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| Veröffentlicht in: | Diabetes care 2013-10, Vol.36 (10), p.3062-3069 |
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| creator | HANSEN, Anne-Louise S CARSTENSEN, Bendix WITTE, Daniel R HELGE, Jørn W JOHANSEN, Nanna B GRAM, Bibi CHRISTIANSEN, Jens S BRAGE, Søren LAURITZEN, Torsten JØRGENSEN, Marit E AADAHL, Mette |
| description | Regular physical activity (PA) reduces the risk of developing type 2 diabetes, and different subtypes of dysglycemia have shown different associations with PA. To better understand the associations of PA and glucose homeostasis, we examined the association of objectively measured PA energy expenditure (PAEE) with detailed measures of glucose homeostasis.
In 1,531 men and women, with low to high risk of developing type 2 diabetes, we measured 7 days of PAEE using a combined accelerometry and heart rate monitor (ActiHeart). Measures and indices of glucose homeostasis were derived from a 3-point oral glucose tolerance test in addition to measures of long-term glycemia (glycated hemoglobin A1c and advanced glycation end products). Associations of PAEE with glucose homeostasis markers were examined using linear regression models.
Median age (IQR) was 66.6 years (62.1-71.6) (54% men) with a median ActiHeart wear time of 6.9 days (6.0-7.1) and PAEE level of 33.0 kJ/kg/day (23.5-46.1). In fully adjusted models, we found higher levels of PAEE to be positively associated with insulin sensitivity and negatively with insulin 2 h after glucose load (P |
| doi_str_mv | 10.2337/dc12-2671 |
| format | Article |
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In 1,531 men and women, with low to high risk of developing type 2 diabetes, we measured 7 days of PAEE using a combined accelerometry and heart rate monitor (ActiHeart). Measures and indices of glucose homeostasis were derived from a 3-point oral glucose tolerance test in addition to measures of long-term glycemia (glycated hemoglobin A1c and advanced glycation end products). Associations of PAEE with glucose homeostasis markers were examined using linear regression models.
Median age (IQR) was 66.6 years (62.1-71.6) (54% men) with a median ActiHeart wear time of 6.9 days (6.0-7.1) and PAEE level of 33.0 kJ/kg/day (23.5-46.1). In fully adjusted models, we found higher levels of PAEE to be positively associated with insulin sensitivity and negatively with insulin 2 h after glucose load (P<0.05).
Even in an elderly population with low levels of PA, we found higher objectively measured PAEE levels to be associated with a more beneficial glucose metabolic profile. Although our findings are cross-sectional, they indicate that even without high-intensity exercise, increasing the overall level of PAEE slightly in an entire population at risk for developing type 2 diabetes may be a realistic and worthwhile goal to reach in order to achieve beneficial effect in terms of glucose metabolism.</description><identifier>ISSN: 0149-5992</identifier><identifier>EISSN: 1935-5548</identifier><identifier>DOI: 10.2337/dc12-2671</identifier><identifier>PMID: 23757430</identifier><identifier>CODEN: DICAD2</identifier><language>eng</language><publisher>Alexandria, VA: American Diabetes Association</publisher><subject>Accelerometers ; Accelerometry ; Aged ; Bioenergetics ; Biological and medical sciences ; Biomarkers ; Blood Glucose - metabolism ; Dextrose ; Diabetes ; Diabetes Mellitus, Type 2 - metabolism ; Diabetes Mellitus, Type 2 - physiopathology ; Diabetes. Impaired glucose tolerance ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Energy Metabolism - physiology ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Female ; Glucose ; Glucose metabolism ; Glucose tolerance tests ; Heart beat ; Heart rate ; Heart Rate - physiology ; Homeostasis ; Humans ; Male ; Medical sciences ; Metabolic diseases ; Middle Aged ; Motor Activity - physiology ; Original Research ; Physical fitness ; Risk factors ; Type 2 diabetes</subject><ispartof>Diabetes care, 2013-10, Vol.36 (10), p.3062-3069</ispartof><rights>2014 INIST-CNRS</rights><rights>COPYRIGHT 2013 American Diabetes Association</rights><rights>Copyright American Diabetes Association Oct 2013</rights><rights>2013 by the American Diabetes Association. 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,315,781,785,886,27925,27926</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27789101$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23757430$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>HANSEN, Anne-Louise S</creatorcontrib><creatorcontrib>CARSTENSEN, Bendix</creatorcontrib><creatorcontrib>WITTE, Daniel R</creatorcontrib><creatorcontrib>HELGE, Jørn W</creatorcontrib><creatorcontrib>JOHANSEN, Nanna B</creatorcontrib><creatorcontrib>GRAM, Bibi</creatorcontrib><creatorcontrib>CHRISTIANSEN, Jens S</creatorcontrib><creatorcontrib>BRAGE, Søren</creatorcontrib><creatorcontrib>LAURITZEN, Torsten</creatorcontrib><creatorcontrib>JØRGENSEN, Marit E</creatorcontrib><creatorcontrib>AADAHL, Mette</creatorcontrib><creatorcontrib>ADDITION-Denmark Steering Committee</creatorcontrib><title>Combined Heart Rate- and Accelerometer-Assessed Physical Activity Energy Expenditure and Associations With Glucose Homeostasis Markers in a Population at High Risk of Developing Diabetes: The ADDITION-PRO study</title><title>Diabetes care</title><addtitle>Diabetes Care</addtitle><description>Regular physical activity (PA) reduces the risk of developing type 2 diabetes, and different subtypes of dysglycemia have shown different associations with PA. To better understand the associations of PA and glucose homeostasis, we examined the association of objectively measured PA energy expenditure (PAEE) with detailed measures of glucose homeostasis.
In 1,531 men and women, with low to high risk of developing type 2 diabetes, we measured 7 days of PAEE using a combined accelerometry and heart rate monitor (ActiHeart). Measures and indices of glucose homeostasis were derived from a 3-point oral glucose tolerance test in addition to measures of long-term glycemia (glycated hemoglobin A1c and advanced glycation end products). Associations of PAEE with glucose homeostasis markers were examined using linear regression models.
Median age (IQR) was 66.6 years (62.1-71.6) (54% men) with a median ActiHeart wear time of 6.9 days (6.0-7.1) and PAEE level of 33.0 kJ/kg/day (23.5-46.1). In fully adjusted models, we found higher levels of PAEE to be positively associated with insulin sensitivity and negatively with insulin 2 h after glucose load (P<0.05).
Even in an elderly population with low levels of PA, we found higher objectively measured PAEE levels to be associated with a more beneficial glucose metabolic profile. Although our findings are cross-sectional, they indicate that even without high-intensity exercise, increasing the overall level of PAEE slightly in an entire population at risk for developing type 2 diabetes may be a realistic and worthwhile goal to reach in order to achieve beneficial effect in terms of glucose metabolism.</description><subject>Accelerometers</subject><subject>Accelerometry</subject><subject>Aged</subject><subject>Bioenergetics</subject><subject>Biological and medical sciences</subject><subject>Biomarkers</subject><subject>Blood Glucose - metabolism</subject><subject>Dextrose</subject><subject>Diabetes</subject><subject>Diabetes Mellitus, Type 2 - metabolism</subject><subject>Diabetes Mellitus, Type 2 - physiopathology</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Energy Metabolism - physiology</subject><subject>Etiopathogenesis. Screening. Investigations. Target tissue resistance</subject><subject>Female</subject><subject>Glucose</subject><subject>Glucose metabolism</subject><subject>Glucose tolerance tests</subject><subject>Heart beat</subject><subject>Heart rate</subject><subject>Heart Rate - physiology</subject><subject>Homeostasis</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metabolic diseases</subject><subject>Middle Aged</subject><subject>Motor Activity - physiology</subject><subject>Original Research</subject><subject>Physical fitness</subject><subject>Risk factors</subject><subject>Type 2 diabetes</subject><issn>0149-5992</issn><issn>1935-5548</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptktFu0zAUhiMEYmVwwQsgSwiJm4w4tuOEi0lVO9ZKg1ZVJS4jxzlOvaV2sZ2KviZPhLcVxtBkS0fy-c5_7N8nSd7i7CwnhH9qJc7TvOD4WTLCFWEpY7R8nowyTKuUVVV-krzy_jrLMkrL8mVykhPOOCXZKPk1sdtGG2jRDIQLaCUCpEiYFo2lhB6c3UIAl469h7hbtNwcvJaij_mg9zoc0IUB18Xwcwem1WFwcF_vvZVaBG2NR9912KDLfpDWA5pFTeuD8Nqjr8LdgPNIGyTQ0u6G_q4CiYBmutuglfY3yCo0hT30dqdNh6ZaNPFO_jNabwCNp9P5er74li5XC-TD0B5eJy-U6D28OcbTZP3lYj2ZpVeLy_lkfJV2NK9CWnLcKEpYwXleMAxUEVywhlZNXhQykxQXOVNMqAwTWeZVE62rMqFoW6pSMXKanN_L7oZmC60EE5zo653TW-EOtRW6fpwxelN3dl8TXmJGyijw8Sjg7I8BfKi32kfPe2HADr7GlHCMY9Mqou__Q6_t4Ex83S1VYVIWLHugOtFDrY2ysa-8Fa3HhHKWZ-SOSp-gOoi_KHprQOl4_Ig_e4KPq4Wtlk8WvPvXmL-O_Bm6CHw4AsLHSVJOGKn9A8d5WeHo-m-WbOTy</recordid><startdate>20131001</startdate><enddate>20131001</enddate><creator>HANSEN, Anne-Louise S</creator><creator>CARSTENSEN, Bendix</creator><creator>WITTE, Daniel R</creator><creator>HELGE, Jørn W</creator><creator>JOHANSEN, Nanna B</creator><creator>GRAM, Bibi</creator><creator>CHRISTIANSEN, Jens S</creator><creator>BRAGE, Søren</creator><creator>LAURITZEN, Torsten</creator><creator>JØRGENSEN, Marit E</creator><creator>AADAHL, Mette</creator><general>American Diabetes Association</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20131001</creationdate><title>Combined Heart Rate- and Accelerometer-Assessed Physical Activity Energy Expenditure and Associations With Glucose Homeostasis Markers in a Population at High Risk of Developing Diabetes: The ADDITION-PRO study</title><author>HANSEN, Anne-Louise S ; CARSTENSEN, Bendix ; WITTE, Daniel R ; HELGE, Jørn W ; JOHANSEN, Nanna B ; GRAM, Bibi ; CHRISTIANSEN, Jens S ; BRAGE, Søren ; LAURITZEN, Torsten ; JØRGENSEN, Marit E ; AADAHL, Mette</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-g429t-871bf4356772651e4f3165b49b266c0c41625f5af013c829b48890af4d8f8f53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Accelerometers</topic><topic>Accelerometry</topic><topic>Aged</topic><topic>Bioenergetics</topic><topic>Biological and medical sciences</topic><topic>Biomarkers</topic><topic>Blood Glucose - metabolism</topic><topic>Dextrose</topic><topic>Diabetes</topic><topic>Diabetes Mellitus, Type 2 - metabolism</topic><topic>Diabetes Mellitus, Type 2 - physiopathology</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Energy Metabolism - physiology</topic><topic>Etiopathogenesis. Screening. Investigations. Target tissue resistance</topic><topic>Female</topic><topic>Glucose</topic><topic>Glucose metabolism</topic><topic>Glucose tolerance tests</topic><topic>Heart beat</topic><topic>Heart rate</topic><topic>Heart Rate - physiology</topic><topic>Homeostasis</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metabolic diseases</topic><topic>Middle Aged</topic><topic>Motor Activity - physiology</topic><topic>Original Research</topic><topic>Physical fitness</topic><topic>Risk factors</topic><topic>Type 2 diabetes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>HANSEN, Anne-Louise S</creatorcontrib><creatorcontrib>CARSTENSEN, Bendix</creatorcontrib><creatorcontrib>WITTE, Daniel R</creatorcontrib><creatorcontrib>HELGE, Jørn W</creatorcontrib><creatorcontrib>JOHANSEN, Nanna B</creatorcontrib><creatorcontrib>GRAM, Bibi</creatorcontrib><creatorcontrib>CHRISTIANSEN, Jens S</creatorcontrib><creatorcontrib>BRAGE, Søren</creatorcontrib><creatorcontrib>LAURITZEN, Torsten</creatorcontrib><creatorcontrib>JØRGENSEN, Marit E</creatorcontrib><creatorcontrib>AADAHL, Mette</creatorcontrib><creatorcontrib>ADDITION-Denmark Steering Committee</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Diabetes care</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>HANSEN, Anne-Louise S</au><au>CARSTENSEN, Bendix</au><au>WITTE, Daniel R</au><au>HELGE, Jørn W</au><au>JOHANSEN, Nanna B</au><au>GRAM, Bibi</au><au>CHRISTIANSEN, Jens S</au><au>BRAGE, Søren</au><au>LAURITZEN, Torsten</au><au>JØRGENSEN, Marit E</au><au>AADAHL, Mette</au><aucorp>ADDITION-Denmark Steering Committee</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Combined Heart Rate- and Accelerometer-Assessed Physical Activity Energy Expenditure and Associations With Glucose Homeostasis Markers in a Population at High Risk of Developing Diabetes: The ADDITION-PRO study</atitle><jtitle>Diabetes care</jtitle><addtitle>Diabetes Care</addtitle><date>2013-10-01</date><risdate>2013</risdate><volume>36</volume><issue>10</issue><spage>3062</spage><epage>3069</epage><pages>3062-3069</pages><issn>0149-5992</issn><eissn>1935-5548</eissn><coden>DICAD2</coden><abstract>Regular physical activity (PA) reduces the risk of developing type 2 diabetes, and different subtypes of dysglycemia have shown different associations with PA. To better understand the associations of PA and glucose homeostasis, we examined the association of objectively measured PA energy expenditure (PAEE) with detailed measures of glucose homeostasis.
In 1,531 men and women, with low to high risk of developing type 2 diabetes, we measured 7 days of PAEE using a combined accelerometry and heart rate monitor (ActiHeart). Measures and indices of glucose homeostasis were derived from a 3-point oral glucose tolerance test in addition to measures of long-term glycemia (glycated hemoglobin A1c and advanced glycation end products). Associations of PAEE with glucose homeostasis markers were examined using linear regression models.
Median age (IQR) was 66.6 years (62.1-71.6) (54% men) with a median ActiHeart wear time of 6.9 days (6.0-7.1) and PAEE level of 33.0 kJ/kg/day (23.5-46.1). In fully adjusted models, we found higher levels of PAEE to be positively associated with insulin sensitivity and negatively with insulin 2 h after glucose load (P<0.05).
Even in an elderly population with low levels of PA, we found higher objectively measured PAEE levels to be associated with a more beneficial glucose metabolic profile. Although our findings are cross-sectional, they indicate that even without high-intensity exercise, increasing the overall level of PAEE slightly in an entire population at risk for developing type 2 diabetes may be a realistic and worthwhile goal to reach in order to achieve beneficial effect in terms of glucose metabolism.</abstract><cop>Alexandria, VA</cop><pub>American Diabetes Association</pub><pmid>23757430</pmid><doi>10.2337/dc12-2671</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Diabetes care, 2013-10, Vol.36 (10), p.3062-3069 |
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| subjects | Accelerometers Accelerometry Aged Bioenergetics Biological and medical sciences Biomarkers Blood Glucose - metabolism Dextrose Diabetes Diabetes Mellitus, Type 2 - metabolism Diabetes Mellitus, Type 2 - physiopathology Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Energy Metabolism - physiology Etiopathogenesis. Screening. Investigations. Target tissue resistance Female Glucose Glucose metabolism Glucose tolerance tests Heart beat Heart rate Heart Rate - physiology Homeostasis Humans Male Medical sciences Metabolic diseases Middle Aged Motor Activity - physiology Original Research Physical fitness Risk factors Type 2 diabetes |
| title | Combined Heart Rate- and Accelerometer-Assessed Physical Activity Energy Expenditure and Associations With Glucose Homeostasis Markers in a Population at High Risk of Developing Diabetes: The ADDITION-PRO study |
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