Skeletal muscles of ambulant children with Duchenne muscular dystrophy: validation of multicenter study of evaluation with MR imaging and MR spectroscopy
To validate a multicenter protocol that examines lower extremity skeletal muscles of children with Duchenne muscular dystrophy (DMD) by using magnetic resonance (MR) imaging and MR spectroscopy in terms of reproducibility of these measurements within and across centers. This HIPAA-compliant study wa...
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| Veröffentlicht in: | Radiology 2013-10, Vol.269 (1), p.198-207 |
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| creator | Forbes, Sean C Walter, Glenn A Rooney, William D Wang, Dah-Jyuu DeVos, Soren Pollaro, Jim Triplett, William Lott, Donovan J Willcocks, Rebecca J Senesac, Claudia Daniels, Michael J Byrne, Barry J Russman, Barry Finkel, Richard S Meyer, James S Sweeney, H Lee Vandenborne, Krista |
| description | To validate a multicenter protocol that examines lower extremity skeletal muscles of children with Duchenne muscular dystrophy (DMD) by using magnetic resonance (MR) imaging and MR spectroscopy in terms of reproducibility of these measurements within and across centers.
This HIPAA-compliant study was approved by the institutional review boards of all participating centers, and informed consent was obtained from each participant or a guardian. Standardized procedures with MR operator training and quality assurance assessments were implemented, and data were acquired at three centers by using different 3-T MR imaging instruments. Measures of maximal cross-sectional area (CSAmax), transverse relaxation time constant (T2), and lipid fraction were compared among centers in two-compartment coaxial phantoms and in two unaffected adult subjects who visited each center. Also, repeat MR measures were acquired twice on separate days in 30 boys with DMD (10 per center) and 10 unaffected boys. Coefficients of variation (CVs) were computed to examine the repeated-measure variabilities within and across centers.
CSAmax, T2 from MR imaging and MR spectroscopy, and lipid fraction were consistent across centers in the phantom (CV, |
| doi_str_mv | 10.1148/radiol.13121948 |
| format | Article |
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This HIPAA-compliant study was approved by the institutional review boards of all participating centers, and informed consent was obtained from each participant or a guardian. Standardized procedures with MR operator training and quality assurance assessments were implemented, and data were acquired at three centers by using different 3-T MR imaging instruments. Measures of maximal cross-sectional area (CSAmax), transverse relaxation time constant (T2), and lipid fraction were compared among centers in two-compartment coaxial phantoms and in two unaffected adult subjects who visited each center. Also, repeat MR measures were acquired twice on separate days in 30 boys with DMD (10 per center) and 10 unaffected boys. Coefficients of variation (CVs) were computed to examine the repeated-measure variabilities within and across centers.
CSAmax, T2 from MR imaging and MR spectroscopy, and lipid fraction were consistent across centers in the phantom (CV, <3%) and in the adult subjects who traveled to each site (CV, 2%-7%). High day-to-day reproducibility in MR measures was observed in boys with DMD (CSAmax, CV = 3.7% [25th percentile, 1.3%; 75th percentile, 5.1%]; contractile area, CV = 4.2% [25th percentile, 0.8%; 75th percentile, 4.9%]; MR imaging T2, CV = 3.1% [25th percentile, 1.2%; 75th percentile, 4.7%]; MR spectroscopy T2, CV = 3.9% [25th percentile, 1.5%; 75th percentile, 5.1%]; and lipid fraction, CV = 4.7% [25th percentile, 1.0%; 75th percentile, 5.3%]).
The MR protocol implemented in this multicenter study achieved highly reproducible measures of lower extremity muscles across centers and from day to day in ambulatory boys with DMD.</description><identifier>ISSN: 0033-8419</identifier><identifier>EISSN: 1527-1315</identifier><identifier>DOI: 10.1148/radiol.13121948</identifier><identifier>PMID: 23696684</identifier><language>eng</language><publisher>United States: Radiological Society of North America, Inc</publisher><subject>Adolescent ; Adult ; Biomarkers - analysis ; Child ; Child, Preschool ; Humans ; Lipids - analysis ; Magnetic Resonance Imaging - methods ; Magnetic Resonance Spectroscopy - methods ; Male ; Muscle, Skeletal - metabolism ; Muscle, Skeletal - pathology ; Muscular Dystrophy, Duchenne - metabolism ; Muscular Dystrophy, Duchenne - pathology ; Original Research ; Reproducibility of Results ; Sensitivity and Specificity ; United States</subject><ispartof>Radiology, 2013-10, Vol.269 (1), p.198-207</ispartof><rights>RSNA, 2013.</rights><rights>RSNA, 2013 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c426t-a7fd9527a122836ab4a321fdc26a189106a7ab8f0ab181d10e3d1e3e056f16e83</citedby><cites>FETCH-LOGICAL-c426t-a7fd9527a122836ab4a321fdc26a189106a7ab8f0ab181d10e3d1e3e056f16e83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23696684$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Forbes, Sean C</creatorcontrib><creatorcontrib>Walter, Glenn A</creatorcontrib><creatorcontrib>Rooney, William D</creatorcontrib><creatorcontrib>Wang, Dah-Jyuu</creatorcontrib><creatorcontrib>DeVos, Soren</creatorcontrib><creatorcontrib>Pollaro, Jim</creatorcontrib><creatorcontrib>Triplett, William</creatorcontrib><creatorcontrib>Lott, Donovan J</creatorcontrib><creatorcontrib>Willcocks, Rebecca J</creatorcontrib><creatorcontrib>Senesac, Claudia</creatorcontrib><creatorcontrib>Daniels, Michael J</creatorcontrib><creatorcontrib>Byrne, Barry J</creatorcontrib><creatorcontrib>Russman, Barry</creatorcontrib><creatorcontrib>Finkel, Richard S</creatorcontrib><creatorcontrib>Meyer, James S</creatorcontrib><creatorcontrib>Sweeney, H Lee</creatorcontrib><creatorcontrib>Vandenborne, Krista</creatorcontrib><title>Skeletal muscles of ambulant children with Duchenne muscular dystrophy: validation of multicenter study of evaluation with MR imaging and MR spectroscopy</title><title>Radiology</title><addtitle>Radiology</addtitle><description>To validate a multicenter protocol that examines lower extremity skeletal muscles of children with Duchenne muscular dystrophy (DMD) by using magnetic resonance (MR) imaging and MR spectroscopy in terms of reproducibility of these measurements within and across centers.
This HIPAA-compliant study was approved by the institutional review boards of all participating centers, and informed consent was obtained from each participant or a guardian. Standardized procedures with MR operator training and quality assurance assessments were implemented, and data were acquired at three centers by using different 3-T MR imaging instruments. Measures of maximal cross-sectional area (CSAmax), transverse relaxation time constant (T2), and lipid fraction were compared among centers in two-compartment coaxial phantoms and in two unaffected adult subjects who visited each center. Also, repeat MR measures were acquired twice on separate days in 30 boys with DMD (10 per center) and 10 unaffected boys. Coefficients of variation (CVs) were computed to examine the repeated-measure variabilities within and across centers.
CSAmax, T2 from MR imaging and MR spectroscopy, and lipid fraction were consistent across centers in the phantom (CV, <3%) and in the adult subjects who traveled to each site (CV, 2%-7%). High day-to-day reproducibility in MR measures was observed in boys with DMD (CSAmax, CV = 3.7% [25th percentile, 1.3%; 75th percentile, 5.1%]; contractile area, CV = 4.2% [25th percentile, 0.8%; 75th percentile, 4.9%]; MR imaging T2, CV = 3.1% [25th percentile, 1.2%; 75th percentile, 4.7%]; MR spectroscopy T2, CV = 3.9% [25th percentile, 1.5%; 75th percentile, 5.1%]; and lipid fraction, CV = 4.7% [25th percentile, 1.0%; 75th percentile, 5.3%]).
The MR protocol implemented in this multicenter study achieved highly reproducible measures of lower extremity muscles across centers and from day to day in ambulatory boys with DMD.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Biomarkers - analysis</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Humans</subject><subject>Lipids - analysis</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Magnetic Resonance Spectroscopy - methods</subject><subject>Male</subject><subject>Muscle, Skeletal - metabolism</subject><subject>Muscle, Skeletal - pathology</subject><subject>Muscular Dystrophy, Duchenne - metabolism</subject><subject>Muscular Dystrophy, Duchenne - pathology</subject><subject>Original Research</subject><subject>Reproducibility of Results</subject><subject>Sensitivity and Specificity</subject><subject>United States</subject><issn>0033-8419</issn><issn>1527-1315</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtv1TAQRi0EopfCmh3ykk1aT-w4DgskVJ5SERKPdeTYkxuDk1xspyg_hX-L09tWsGJljX18NDMfIU-BnQEIdR60dbM_Aw4lNELdIzuoyrrIdXWf7BjjvFACmhPyKMbvjIGoVP2QnJRcNlIqsSO_v_xAj0l7Oi7ReIx07qkeu8XrKVEzOG8DTvSXSwN9vZgBpwmv0QwEateYwnwY1hf0SntndXLztBnGxSdncEoYaEyLXbdLzMxyRK59Hz9TN-q9m_ZUT3Yr4wFNFkYzH9bH5EGvfcQnN-cp-fb2zdeL98Xlp3cfLl5dFkaUMhW67m2TZ9ZQlopL3QnNS-itKaUG1QCTutad6pnuQIEFhtwCcmSV7EGi4qfk5dF7WLoR7dZ00L49hNxbWNtZu_bfl8kN7X6-anmtgFdNFjy_EYT554IxtaOLBn3eIM5LbEECSF6XnP0fFYLzhomqyuj5ETV5HzFgf9cRsHbLvj1m395mn388-3uQO_42bP4HSIuwRQ</recordid><startdate>201310</startdate><enddate>201310</enddate><creator>Forbes, Sean C</creator><creator>Walter, Glenn A</creator><creator>Rooney, William D</creator><creator>Wang, Dah-Jyuu</creator><creator>DeVos, Soren</creator><creator>Pollaro, Jim</creator><creator>Triplett, William</creator><creator>Lott, Donovan J</creator><creator>Willcocks, Rebecca J</creator><creator>Senesac, Claudia</creator><creator>Daniels, Michael J</creator><creator>Byrne, Barry J</creator><creator>Russman, Barry</creator><creator>Finkel, Richard S</creator><creator>Meyer, James S</creator><creator>Sweeney, H Lee</creator><creator>Vandenborne, Krista</creator><general>Radiological Society of North America, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QP</scope><scope>5PM</scope></search><sort><creationdate>201310</creationdate><title>Skeletal muscles of ambulant children with Duchenne muscular dystrophy: validation of multicenter study of evaluation with MR imaging and MR spectroscopy</title><author>Forbes, Sean C ; Walter, Glenn A ; Rooney, William D ; Wang, Dah-Jyuu ; DeVos, Soren ; Pollaro, Jim ; Triplett, William ; Lott, Donovan J ; Willcocks, Rebecca J ; Senesac, Claudia ; Daniels, Michael J ; Byrne, Barry J ; Russman, Barry ; Finkel, Richard S ; Meyer, James S ; Sweeney, H Lee ; Vandenborne, Krista</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c426t-a7fd9527a122836ab4a321fdc26a189106a7ab8f0ab181d10e3d1e3e056f16e83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Biomarkers - analysis</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Humans</topic><topic>Lipids - analysis</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Magnetic Resonance Spectroscopy - methods</topic><topic>Male</topic><topic>Muscle, Skeletal - metabolism</topic><topic>Muscle, Skeletal - pathology</topic><topic>Muscular Dystrophy, Duchenne - metabolism</topic><topic>Muscular Dystrophy, Duchenne - pathology</topic><topic>Original Research</topic><topic>Reproducibility of Results</topic><topic>Sensitivity and Specificity</topic><topic>United States</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Forbes, Sean C</creatorcontrib><creatorcontrib>Walter, Glenn A</creatorcontrib><creatorcontrib>Rooney, William D</creatorcontrib><creatorcontrib>Wang, Dah-Jyuu</creatorcontrib><creatorcontrib>DeVos, Soren</creatorcontrib><creatorcontrib>Pollaro, Jim</creatorcontrib><creatorcontrib>Triplett, William</creatorcontrib><creatorcontrib>Lott, Donovan J</creatorcontrib><creatorcontrib>Willcocks, Rebecca J</creatorcontrib><creatorcontrib>Senesac, Claudia</creatorcontrib><creatorcontrib>Daniels, Michael J</creatorcontrib><creatorcontrib>Byrne, Barry J</creatorcontrib><creatorcontrib>Russman, Barry</creatorcontrib><creatorcontrib>Finkel, Richard S</creatorcontrib><creatorcontrib>Meyer, James S</creatorcontrib><creatorcontrib>Sweeney, H Lee</creatorcontrib><creatorcontrib>Vandenborne, Krista</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Forbes, Sean C</au><au>Walter, Glenn A</au><au>Rooney, William D</au><au>Wang, Dah-Jyuu</au><au>DeVos, Soren</au><au>Pollaro, Jim</au><au>Triplett, William</au><au>Lott, Donovan J</au><au>Willcocks, Rebecca J</au><au>Senesac, Claudia</au><au>Daniels, Michael J</au><au>Byrne, Barry J</au><au>Russman, Barry</au><au>Finkel, Richard S</au><au>Meyer, James S</au><au>Sweeney, H Lee</au><au>Vandenborne, Krista</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Skeletal muscles of ambulant children with Duchenne muscular dystrophy: validation of multicenter study of evaluation with MR imaging and MR spectroscopy</atitle><jtitle>Radiology</jtitle><addtitle>Radiology</addtitle><date>2013-10</date><risdate>2013</risdate><volume>269</volume><issue>1</issue><spage>198</spage><epage>207</epage><pages>198-207</pages><issn>0033-8419</issn><eissn>1527-1315</eissn><abstract>To validate a multicenter protocol that examines lower extremity skeletal muscles of children with Duchenne muscular dystrophy (DMD) by using magnetic resonance (MR) imaging and MR spectroscopy in terms of reproducibility of these measurements within and across centers.
This HIPAA-compliant study was approved by the institutional review boards of all participating centers, and informed consent was obtained from each participant or a guardian. Standardized procedures with MR operator training and quality assurance assessments were implemented, and data were acquired at three centers by using different 3-T MR imaging instruments. Measures of maximal cross-sectional area (CSAmax), transverse relaxation time constant (T2), and lipid fraction were compared among centers in two-compartment coaxial phantoms and in two unaffected adult subjects who visited each center. Also, repeat MR measures were acquired twice on separate days in 30 boys with DMD (10 per center) and 10 unaffected boys. Coefficients of variation (CVs) were computed to examine the repeated-measure variabilities within and across centers.
CSAmax, T2 from MR imaging and MR spectroscopy, and lipid fraction were consistent across centers in the phantom (CV, <3%) and in the adult subjects who traveled to each site (CV, 2%-7%). High day-to-day reproducibility in MR measures was observed in boys with DMD (CSAmax, CV = 3.7% [25th percentile, 1.3%; 75th percentile, 5.1%]; contractile area, CV = 4.2% [25th percentile, 0.8%; 75th percentile, 4.9%]; MR imaging T2, CV = 3.1% [25th percentile, 1.2%; 75th percentile, 4.7%]; MR spectroscopy T2, CV = 3.9% [25th percentile, 1.5%; 75th percentile, 5.1%]; and lipid fraction, CV = 4.7% [25th percentile, 1.0%; 75th percentile, 5.3%]).
The MR protocol implemented in this multicenter study achieved highly reproducible measures of lower extremity muscles across centers and from day to day in ambulatory boys with DMD.</abstract><cop>United States</cop><pub>Radiological Society of North America, Inc</pub><pmid>23696684</pmid><doi>10.1148/radiol.13121948</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Radiology, 2013-10, Vol.269 (1), p.198-207 |
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| subjects | Adolescent Adult Biomarkers - analysis Child Child, Preschool Humans Lipids - analysis Magnetic Resonance Imaging - methods Magnetic Resonance Spectroscopy - methods Male Muscle, Skeletal - metabolism Muscle, Skeletal - pathology Muscular Dystrophy, Duchenne - metabolism Muscular Dystrophy, Duchenne - pathology Original Research Reproducibility of Results Sensitivity and Specificity United States |
| title | Skeletal muscles of ambulant children with Duchenne muscular dystrophy: validation of multicenter study of evaluation with MR imaging and MR spectroscopy |
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