Variable steroid receptor responses: Intrinsically disordered AF1 is the key

[Display omitted] •Control of steroid hormone specifity in regulation of gene expression.•Cofactor-induced changes in receptor structure.•Alteration of remote regions of receptor structure by steroidal ligand.•Modulation of ligand potency and efficacy by changing cofactor concentration. Steroid horm...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Molecular and cellular endocrinology 2013-08, Vol.376 (1-2), p.81-84
Hauptverfasser:	Simons, S. Stoney, Kumar, Raj
Format:	Artikel
Sprache:	eng
Schlagworte:	adverse effects AF1 domain as a molecular rheostat Amax and EC50 Effectiveness Genes Glucocorticoids Hormones Hormones - chemistry Hormones - metabolism Hormones - pharmacology Humans Intrinsically disordered domains Ligands Protein Binding Protein Folding Protein Structure, Tertiary Receptors Receptors, Steroid - chemistry Receptors, Steroid - genetics Receptors, Steroid - metabolism Remote regions Selective receptor modulators (SRMs) Selectivity in controlling gene expression Signal Transduction - drug effects steroid hormones Steroid receptors Steroids Steroids - chemistry Steroids - metabolism Steroids - pharmacology Transcriptional Activation - drug effects
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!