Pathway-based analysis of primary biliary cirrhosis genome-wide association studies

Genome-wide association studies (GWAS) have successfully identified several loci associated with primary biliary cirrhosis (PBC) risk. Pathway analysis complements conventional GWAS analysis. We applied the recently developed linear combination test for pathways to datasets drawn from independent PB...

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Veröffentlicht in:	Genes and immunity 2013-04, Vol.14 (3), p.179-186
Hauptverfasser:	Kar, S P, Seldin, M F, Chen, W, Lu, E, Hirschfield, G M, Invernizzi, P, Heathcote, J, Cusi, D, Gershwin, M E, Siminovitch, K A, Amos, C I
Format:	Artikel
Sprache:	eng
Schlagworte:	631/208/205/2138 631/80/86 692/699/1503/1607/1606 Algorithms Analysis Autoimmune diseases Biliary cirrhosis Biomedical and Life Sciences Biomedical research Biomedicine Canada Cancer Research Cirrhosis Cohort Studies Databases, Genetic Datasets Development and progression Etiology Female Gene Expression Gene Frequency Gene loci Gene set enrichment analysis Genetic aspects Genetic Predisposition to Disease - genetics Genetics Genome-wide association studies Genome-Wide Association Study - methods Genomes Genotype Hedgehog protein Hedgehog proteins Human Genetics Humans Immunology Italy Linkage Disequilibrium Liver cirrhosis Liver Cirrhosis, Biliary - genetics Liver diseases Male Medicine Meta-Analysis as Topic Middle Aged original-article Phosphatidylinositol Physiological aspects Polymorphism, Single Nucleotide Primary biliary cirrhosis Quantitative trait loci Signal transduction Signal Transduction - genetics
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