Brain White Matter Tract Integrity and Cognitive Abilities in Community-Dwelling Older People: The Lothian Birth Cohort, 1936
Objective: The present study investigates associations between brain white matter tract integrity and cognitive abilities in community-dwelling older people (N = 655). We explored two potential confounds of white matter tract−cognition associations in later life: (a) whether the associations between...
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| Veröffentlicht in: | Neuropsychology 2013-09, Vol.27 (5), p.595-607 |
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| creator | Booth, Tom Bastin, Mark E. Penke, Lars Maniega, Susana Muñoz Murray, Catherine Royle, Natalie A. Gow, Alan J. Corley, Janie Henderson, Ross D. Valdés Hernández, Maria del C. Starr, John M. Wardlaw, Joanna M. Deary, Ian J. |
| description | Objective: The present study investigates associations between brain white matter tract integrity and cognitive abilities in community-dwelling older people (N = 655). We explored two potential confounds of white matter tract−cognition associations in later life: (a) whether the associations between tracts and specific cognitive abilities are accounted for by general cognitive ability (g); and (b) how the presence of atrophy and white matter lesions affect these associations. Method: Tract integrity was determined using quantitative diffusion magnetic resonance imaging tractography (tract-averaged fractional anisotropy [FA]). Using confirmatory factor analysis, we compared first-order and bifactor models to investigate whether specific tract-ability associations were accounted for by g. Results: Significant associations were found between g and FA in bilateral anterior thalamic radiations (r range: .16−.18, p < .01), uncinate (r range: .19−.26, p < .001), arcuate fasciculi (r range: .11−.12, p < .05), and the splenium of corpus callosum (r = .14, p < .01). After controlling for g within the bifactor model, some significant specific cognitive domain associations remained. Results also suggest that the primary effects of controlling for whole brain integrity were on g associations, not specific abilities. Conclusion: Results suggest that g accounts for most of, but not all, the tract−cognition associations in the current data. When controlling for age-related overall brain structural changes, only minor attenuations of the tract−cognition associations were found, and these were primarily with g. In totality, the results highlight the importance of controlling for g when investigating associations between specific cognitive abilities and neuropsychology variables. |
| doi_str_mv | 10.1037/a0033354 |
| format | Article |
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We explored two potential confounds of white matter tract−cognition associations in later life: (a) whether the associations between tracts and specific cognitive abilities are accounted for by general cognitive ability (g); and (b) how the presence of atrophy and white matter lesions affect these associations. Method: Tract integrity was determined using quantitative diffusion magnetic resonance imaging tractography (tract-averaged fractional anisotropy [FA]). Using confirmatory factor analysis, we compared first-order and bifactor models to investigate whether specific tract-ability associations were accounted for by g. Results: Significant associations were found between g and FA in bilateral anterior thalamic radiations (r range: .16−.18, p < .01), uncinate (r range: .19−.26, p < .001), arcuate fasciculi (r range: .11−.12, p < .05), and the splenium of corpus callosum (r = .14, p < .01). After controlling for g within the bifactor model, some significant specific cognitive domain associations remained. Results also suggest that the primary effects of controlling for whole brain integrity were on g associations, not specific abilities. Conclusion: Results suggest that g accounts for most of, but not all, the tract−cognition associations in the current data. When controlling for age-related overall brain structural changes, only minor attenuations of the tract−cognition associations were found, and these were primarily with g. In totality, the results highlight the importance of controlling for g when investigating associations between specific cognitive abilities and neuropsychology variables.</description><identifier>ISSN: 0894-4105</identifier><identifier>EISSN: 1931-1559</identifier><identifier>DOI: 10.1037/a0033354</identifier><identifier>PMID: 23937481</identifier><language>eng</language><publisher>Washington, DC: American Psychological Association</publisher><subject>Adult. Elderly ; Aged ; Aging ; Aging - pathology ; Aging - physiology ; Aging - psychology ; Anatomical correlates of behavior ; Behavioral psychophysiology ; Biological and medical sciences ; Brain - pathology ; Brain - physiology ; Cognition - physiology ; Cognitive Ability ; Cohort Studies ; Communities ; Developmental psychology ; Diffusion Tensor Imaging ; Fundamental and applied biological sciences. Psychology ; Human ; Humans ; Memory - physiology ; Nerve Fibers - pathology ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; Scotland ; White Matter</subject><ispartof>Neuropsychology, 2013-09, Vol.27 (5), p.595-607</ispartof><rights>2013 the Authors</rights><rights>2015 INIST-CNRS</rights><rights>2013, American Psychological Association</rights><rights>2013 the Authors 2013 the Authors</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a466t-28bfd0268f4f72e735a99ebb6f9167d524a07831460bdf49a0aed92aaae065773</citedby><orcidid>0000-0002-1733-263X ; 0000-0002-3320-4531 ; 0000-0002-9484-580X ; 0000-0002-0490-0845</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27922,27923</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27716768$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23937481$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Brown, Gregory G</contributor><contributor>Rao, Stephen M</contributor><creatorcontrib>Booth, Tom</creatorcontrib><creatorcontrib>Bastin, Mark E.</creatorcontrib><creatorcontrib>Penke, Lars</creatorcontrib><creatorcontrib>Maniega, Susana Muñoz</creatorcontrib><creatorcontrib>Murray, Catherine</creatorcontrib><creatorcontrib>Royle, Natalie A.</creatorcontrib><creatorcontrib>Gow, Alan J.</creatorcontrib><creatorcontrib>Corley, Janie</creatorcontrib><creatorcontrib>Henderson, Ross D.</creatorcontrib><creatorcontrib>Valdés Hernández, Maria del C.</creatorcontrib><creatorcontrib>Starr, John M.</creatorcontrib><creatorcontrib>Wardlaw, Joanna M.</creatorcontrib><creatorcontrib>Deary, Ian J.</creatorcontrib><title>Brain White Matter Tract Integrity and Cognitive Abilities in Community-Dwelling Older People: The Lothian Birth Cohort, 1936</title><title>Neuropsychology</title><addtitle>Neuropsychology</addtitle><description>Objective: The present study investigates associations between brain white matter tract integrity and cognitive abilities in community-dwelling older people (N = 655). We explored two potential confounds of white matter tract−cognition associations in later life: (a) whether the associations between tracts and specific cognitive abilities are accounted for by general cognitive ability (g); and (b) how the presence of atrophy and white matter lesions affect these associations. Method: Tract integrity was determined using quantitative diffusion magnetic resonance imaging tractography (tract-averaged fractional anisotropy [FA]). Using confirmatory factor analysis, we compared first-order and bifactor models to investigate whether specific tract-ability associations were accounted for by g. Results: Significant associations were found between g and FA in bilateral anterior thalamic radiations (r range: .16−.18, p < .01), uncinate (r range: .19−.26, p < .001), arcuate fasciculi (r range: .11−.12, p < .05), and the splenium of corpus callosum (r = .14, p < .01). After controlling for g within the bifactor model, some significant specific cognitive domain associations remained. Results also suggest that the primary effects of controlling for whole brain integrity were on g associations, not specific abilities. Conclusion: Results suggest that g accounts for most of, but not all, the tract−cognition associations in the current data. When controlling for age-related overall brain structural changes, only minor attenuations of the tract−cognition associations were found, and these were primarily with g. In totality, the results highlight the importance of controlling for g when investigating associations between specific cognitive abilities and neuropsychology variables.</description><subject>Adult. Elderly</subject><subject>Aged</subject><subject>Aging</subject><subject>Aging - pathology</subject><subject>Aging - physiology</subject><subject>Aging - psychology</subject><subject>Anatomical correlates of behavior</subject><subject>Behavioral psychophysiology</subject><subject>Biological and medical sciences</subject><subject>Brain - pathology</subject><subject>Brain - physiology</subject><subject>Cognition - physiology</subject><subject>Cognitive Ability</subject><subject>Cohort Studies</subject><subject>Communities</subject><subject>Developmental psychology</subject><subject>Diffusion Tensor Imaging</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Human</subject><subject>Humans</subject><subject>Memory - physiology</subject><subject>Nerve Fibers - pathology</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Scotland</subject><subject>White Matter</subject><issn>0894-4105</issn><issn>1931-1559</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkd1rFDEUxQdR7FoF_wIJiCDoaDL5mvFBaNevwkp9WPEx3Jm5s5Mym2yTTGUf_N-NdNuqTwm5v3s4J6conjL6hlGu3wKlnHMp7hUL1nBWMimb-8WC1o0oBaPyqHgU4wWl-UHJh8VRxRuuRc0Wxa_TANaRH6NNSL5CShjIOkCXyJlLuAk27Qm4niz9xtlkr5CctHbKN4wk7y39djvnwb788BOnyboNOZ_6rPEN_W7Cd2Q9Iln5NFpw5NSGNOaV0Yf0mmSj6nHxYIAp4pPDeVx8__RxvfxSrs4_ny1PViUIpVJZ1e3Q00rVgxh0hZpLaBpsWzU0TOleVgKorjkTirb9IBqggH1TAQBSJbXmx8X7a93d3G6x79ClAJPZBbuFsDcerPl34uxoNv7KcF1TzUQWeHkQCP5yxpjM1sYuJwaHfo4mI1wyxYXK6PP_0As_B5fjZaqiUtQZuxPsgo8x4HBrhlHzp1Nz02lGn_1t_ha8KTEDLw4AxA6mIYDrbLzjtM6_pOrMvbrmYAdmF_cdhGS7CWM3h5CDG4dzpo00spH8N8EBuBM</recordid><startdate>20130901</startdate><enddate>20130901</enddate><creator>Booth, Tom</creator><creator>Bastin, Mark E.</creator><creator>Penke, Lars</creator><creator>Maniega, Susana Muñoz</creator><creator>Murray, Catherine</creator><creator>Royle, Natalie A.</creator><creator>Gow, Alan J.</creator><creator>Corley, Janie</creator><creator>Henderson, Ross D.</creator><creator>Valdés Hernández, Maria del C.</creator><creator>Starr, John M.</creator><creator>Wardlaw, Joanna M.</creator><creator>Deary, Ian J.</creator><general>American Psychological Association</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7RZ</scope><scope>PSYQQ</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-1733-263X</orcidid><orcidid>https://orcid.org/0000-0002-3320-4531</orcidid><orcidid>https://orcid.org/0000-0002-9484-580X</orcidid><orcidid>https://orcid.org/0000-0002-0490-0845</orcidid></search><sort><creationdate>20130901</creationdate><title>Brain White Matter Tract Integrity and Cognitive Abilities in Community-Dwelling Older People: The Lothian Birth Cohort, 1936</title><author>Booth, Tom ; Bastin, Mark E. ; Penke, Lars ; Maniega, Susana Muñoz ; Murray, Catherine ; Royle, Natalie A. ; Gow, Alan J. ; Corley, Janie ; Henderson, Ross D. ; Valdés Hernández, Maria del C. ; Starr, John M. ; Wardlaw, Joanna M. ; Deary, Ian J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a466t-28bfd0268f4f72e735a99ebb6f9167d524a07831460bdf49a0aed92aaae065773</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult. Elderly</topic><topic>Aged</topic><topic>Aging</topic><topic>Aging - pathology</topic><topic>Aging - physiology</topic><topic>Aging - psychology</topic><topic>Anatomical correlates of behavior</topic><topic>Behavioral psychophysiology</topic><topic>Biological and medical sciences</topic><topic>Brain - pathology</topic><topic>Brain - physiology</topic><topic>Cognition - physiology</topic><topic>Cognitive Ability</topic><topic>Cohort Studies</topic><topic>Communities</topic><topic>Developmental psychology</topic><topic>Diffusion Tensor Imaging</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Human</topic><topic>Humans</topic><topic>Memory - physiology</topic><topic>Nerve Fibers - pathology</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. Psychophysiology</topic><topic>Scotland</topic><topic>White Matter</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Booth, Tom</creatorcontrib><creatorcontrib>Bastin, Mark E.</creatorcontrib><creatorcontrib>Penke, Lars</creatorcontrib><creatorcontrib>Maniega, Susana Muñoz</creatorcontrib><creatorcontrib>Murray, Catherine</creatorcontrib><creatorcontrib>Royle, Natalie A.</creatorcontrib><creatorcontrib>Gow, Alan J.</creatorcontrib><creatorcontrib>Corley, Janie</creatorcontrib><creatorcontrib>Henderson, Ross D.</creatorcontrib><creatorcontrib>Valdés Hernández, Maria del C.</creatorcontrib><creatorcontrib>Starr, John M.</creatorcontrib><creatorcontrib>Wardlaw, Joanna M.</creatorcontrib><creatorcontrib>Deary, Ian J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>APA PsycArticles®</collection><collection>ProQuest One Psychology</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Neuropsychology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Booth, Tom</au><au>Bastin, Mark E.</au><au>Penke, Lars</au><au>Maniega, Susana Muñoz</au><au>Murray, Catherine</au><au>Royle, Natalie A.</au><au>Gow, Alan J.</au><au>Corley, Janie</au><au>Henderson, Ross D.</au><au>Valdés Hernández, Maria del C.</au><au>Starr, John M.</au><au>Wardlaw, Joanna M.</au><au>Deary, Ian J.</au><au>Brown, Gregory G</au><au>Rao, Stephen M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Brain White Matter Tract Integrity and Cognitive Abilities in Community-Dwelling Older People: The Lothian Birth Cohort, 1936</atitle><jtitle>Neuropsychology</jtitle><addtitle>Neuropsychology</addtitle><date>2013-09-01</date><risdate>2013</risdate><volume>27</volume><issue>5</issue><spage>595</spage><epage>607</epage><pages>595-607</pages><issn>0894-4105</issn><eissn>1931-1559</eissn><abstract>Objective: The present study investigates associations between brain white matter tract integrity and cognitive abilities in community-dwelling older people (N = 655). We explored two potential confounds of white matter tract−cognition associations in later life: (a) whether the associations between tracts and specific cognitive abilities are accounted for by general cognitive ability (g); and (b) how the presence of atrophy and white matter lesions affect these associations. Method: Tract integrity was determined using quantitative diffusion magnetic resonance imaging tractography (tract-averaged fractional anisotropy [FA]). Using confirmatory factor analysis, we compared first-order and bifactor models to investigate whether specific tract-ability associations were accounted for by g. Results: Significant associations were found between g and FA in bilateral anterior thalamic radiations (r range: .16−.18, p < .01), uncinate (r range: .19−.26, p < .001), arcuate fasciculi (r range: .11−.12, p < .05), and the splenium of corpus callosum (r = .14, p < .01). After controlling for g within the bifactor model, some significant specific cognitive domain associations remained. Results also suggest that the primary effects of controlling for whole brain integrity were on g associations, not specific abilities. Conclusion: Results suggest that g accounts for most of, but not all, the tract−cognition associations in the current data. When controlling for age-related overall brain structural changes, only minor attenuations of the tract−cognition associations were found, and these were primarily with g. In totality, the results highlight the importance of controlling for g when investigating associations between specific cognitive abilities and neuropsychology variables.</abstract><cop>Washington, DC</cop><pub>American Psychological Association</pub><pmid>23937481</pmid><doi>10.1037/a0033354</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0002-1733-263X</orcidid><orcidid>https://orcid.org/0000-0002-3320-4531</orcidid><orcidid>https://orcid.org/0000-0002-9484-580X</orcidid><orcidid>https://orcid.org/0000-0002-0490-0845</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adult. Elderly Aged Aging Aging - pathology Aging - physiology Aging - psychology Anatomical correlates of behavior Behavioral psychophysiology Biological and medical sciences Brain - pathology Brain - physiology Cognition - physiology Cognitive Ability Cohort Studies Communities Developmental psychology Diffusion Tensor Imaging Fundamental and applied biological sciences. Psychology Human Humans Memory - physiology Nerve Fibers - pathology Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Scotland White Matter |
| title | Brain White Matter Tract Integrity and Cognitive Abilities in Community-Dwelling Older People: The Lothian Birth Cohort, 1936 |
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