Efficient Use of Exogenous Isoprenols for Protein Isoprenylation by MDA-MB-231 Cells Is Regulated Independently of the Mevalonate Pathway

Mammalian cells can use exogenous isoprenols to generate isoprenoid diphosphate substrates for protein isoprenylation, but the mechanism, efficiency, and biological importance of this process are not known. We developed mass spectrometry-based methods using chemical probes and newly synthesized stab...

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Veröffentlicht in:	The Journal of biological chemistry 2013-09, Vol.288 (38), p.27444-27455
Hauptverfasser:	Onono, Fredrick, Subramanian, Thangaiah, Sunkara, Manjula, Subramanian, Karunai Leela, Spielmann, H. Peter, Morris, Andrew J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - pharmacokinetics Antineoplastic Agents - pharmacology Breast Cancer Cell Line, Tumor Cholesterol Diterpenes - pharmacokinetics Diterpenes - pharmacology Farnesol - analogs & derivatives Farnesol - pharmacokinetics Farnesol - pharmacology Humans Hydroxymethylglutaryl CoA Reductases - genetics Hydroxymethylglutaryl CoA Reductases - metabolism Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacokinetics Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology Isoprenoid Lipids Mass Spectrometry (MS) Mevalonic Acid - metabolism Mutation Neoplasms - drug therapy Neoplasms - genetics Neoplasms - metabolism Neoplasms - pathology Polyisoprenyl Phosphates - metabolism Protein Isoprenylation Protein Prenylation - drug effects Protein Prenylation - genetics Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism
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