Persistent human herpesvirus-6 infection in patients with an inherited form of the virus
Human herpesvirus‐6 (HHV‐6)A and 6B are ubiquitous betaherpesviruses viruses with lymphotropic and neurotropic potential. As reported earlier, these viruses establish latency by integration into the telomeres of host chromosomes. Chromosomally integrated HHV‐6 (CIHHV‐6) can be transmitted vertically...
Gespeichert in:
| Veröffentlicht in: | Journal of medical virology 2013-11, Vol.85 (11), p.1940-1946 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1946 |
|---|---|
| container_issue | 11 |
| container_start_page | 1940 |
| container_title | Journal of medical virology |
| container_volume | 85 |
| creator | Pantry, Shara N. Medveczky, Maria M. Arbuckle, Jesse H. Luka, Janos Montoya, Jose G. Hu, Jianhong Renne, Rolf Peterson, Daniel Pritchett, Joshua C. Ablashi, Dharam V. Medveczky, Peter G. |
| description | Human herpesvirus‐6 (HHV‐6)A and 6B are ubiquitous betaherpesviruses viruses with lymphotropic and neurotropic potential. As reported earlier, these viruses establish latency by integration into the telomeres of host chromosomes. Chromosomally integrated HHV‐6 (CIHHV‐6) can be transmitted vertically from parent to child. Some CIHHV‐6 patients are suffering from neurological symptoms, while others remain asymptomatic. Four patients with CIHHV‐6 and CNS dysfunction were treated with valganciclovir or foscarnet. HHV‐6 replication was detected by reverse transcriptase polymerase chain reaction amplification of a late envelope glycoprotein. In this study we also compared the inherited and persistent HHV‐6 viruses by DNA sequencing. The prevalence of CIHHV‐6 in this cohort of adult patients from the USA suffering from a wide range of neurological symptoms including long‐term fatigue were found significantly greater than the reported 0.8% in the general population. Long‐term antiviral therapy inhibited HHV‐6 replication as documented by loss of viral mRNA production. Sequence comparison of the mRNA and the inherited viral genome revealed that the transcript is produced by an exogenous virus. In conclusion, the data presented here document that some individuals with CIHHV‐6 are infected persistently with exogenous HHV‐6 strains that lead to a wide range of neurological symptoms; the proposed name for this condition is inherited herpesvirus 6 syndrome or IHS. J Med. Virol. 85:1940–1946, 2013. © 2013 Wiley Periodicals, Inc. |
| doi_str_mv | 10.1002/jmv.23685 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3779660</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1428772168</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5445-32be05d946cf3f0506a732356cfdee36e1b9d2fbed92703e2d584b5cbdabdee43</originalsourceid><addsrcrecordid>eNqN0klv1DAUAGALgegwcOAPIEsICQ5pvcR2cqlUFVqopgWJQrlZTvJCPE3iwU6m9N_jWTosUiVOcZzvLfEzQs8p2aeEsIN5t9xnXGbiAZpQksskJ4o-RBNCU5lIScUeehLCnBCS5Yw9RnuMZzlXgk_Qt0_ggw0D9ANuxs70uAG_gLC0fgyJxLavoRys6-MKL8xgIwz4xg4NNqu9qO0AFa6d77Cr8dAAXsc-RY9q0wZ4tn1O0ZeTd5fH75PZx9MPx0ezpBRpKhLOCiCiylNZ1rwmgkijOOMivlYAXAIt8orVBVQ5U4QDq0SWFqIsKlNEkPIpOtzkXYxFB1UZ-_Om1QtvO-NvtTNW__2lt43-7paaK5VLSWKC19sE3v0YIQy6s6GEtjU9uDFomvKUcJYp9R90xRiVWaQv_6FzN_o-nsRaUcmVpFG92ajSuxA81Lu-KdGr0eo4Wr0ebbQv_vzRnbybZQSvtsCE0rS1N31pw28XOyMsnu0UHWzcjW3h9v6K-uz8613pZBOxuig_dxHGX2upYm19dXGqZ29PPl-dnV_qnP8CBNzLSg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1428163761</pqid></control><display><type>article</type><title>Persistent human herpesvirus-6 infection in patients with an inherited form of the virus</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Pantry, Shara N. ; Medveczky, Maria M. ; Arbuckle, Jesse H. ; Luka, Janos ; Montoya, Jose G. ; Hu, Jianhong ; Renne, Rolf ; Peterson, Daniel ; Pritchett, Joshua C. ; Ablashi, Dharam V. ; Medveczky, Peter G.</creator><creatorcontrib>Pantry, Shara N. ; Medveczky, Maria M. ; Arbuckle, Jesse H. ; Luka, Janos ; Montoya, Jose G. ; Hu, Jianhong ; Renne, Rolf ; Peterson, Daniel ; Pritchett, Joshua C. ; Ablashi, Dharam V. ; Medveczky, Peter G.</creatorcontrib><description>Human herpesvirus‐6 (HHV‐6)A and 6B are ubiquitous betaherpesviruses viruses with lymphotropic and neurotropic potential. As reported earlier, these viruses establish latency by integration into the telomeres of host chromosomes. Chromosomally integrated HHV‐6 (CIHHV‐6) can be transmitted vertically from parent to child. Some CIHHV‐6 patients are suffering from neurological symptoms, while others remain asymptomatic. Four patients with CIHHV‐6 and CNS dysfunction were treated with valganciclovir or foscarnet. HHV‐6 replication was detected by reverse transcriptase polymerase chain reaction amplification of a late envelope glycoprotein. In this study we also compared the inherited and persistent HHV‐6 viruses by DNA sequencing. The prevalence of CIHHV‐6 in this cohort of adult patients from the USA suffering from a wide range of neurological symptoms including long‐term fatigue were found significantly greater than the reported 0.8% in the general population. Long‐term antiviral therapy inhibited HHV‐6 replication as documented by loss of viral mRNA production. Sequence comparison of the mRNA and the inherited viral genome revealed that the transcript is produced by an exogenous virus. In conclusion, the data presented here document that some individuals with CIHHV‐6 are infected persistently with exogenous HHV‐6 strains that lead to a wide range of neurological symptoms; the proposed name for this condition is inherited herpesvirus 6 syndrome or IHS. J Med. Virol. 85:1940–1946, 2013. © 2013 Wiley Periodicals, Inc.</description><identifier>ISSN: 0146-6615</identifier><identifier>EISSN: 1096-9071</identifier><identifier>DOI: 10.1002/jmv.23685</identifier><identifier>PMID: 23893753</identifier><identifier>CODEN: JMVIDB</identifier><language>eng</language><publisher>Hoboken, NJ: Blackwell Publishing Ltd</publisher><subject>Adult ; Antiviral Agents - administration & dosage ; antiviral drug treatment ; Biological and medical sciences ; Central nervous system ; chronic fatigue syndrome ; Cohort Studies ; DNA, Viral - genetics ; Foscarnet - administration & dosage ; Fundamental and applied biological sciences. Psychology ; Ganciclovir - administration & dosage ; Ganciclovir - analogs & derivatives ; Herpesvirus ; Herpesvirus 6, Human - isolation & purification ; Herpesvirus 6, Human - physiology ; HHV-6 ; human herpesvirus 6 ; Human viral diseases ; Humans ; Infectious Disease Transmission, Vertical ; Infectious diseases ; integration ; Medical sciences ; Microbiology ; Miscellaneous ; Prevalence ; RNA, Viral - genetics ; Roseolovirus Infections - epidemiology ; Roseolovirus Infections - pathology ; Roseolovirus Infections - transmission ; Roseolovirus Infections - virology ; Sequence Analysis, DNA ; Treatment Outcome ; United States - epidemiology ; Viral diseases ; Virology ; Virus Replication - drug effects</subject><ispartof>Journal of medical virology, 2013-11, Vol.85 (11), p.1940-1946</ispartof><rights>Copyright © 2013 Wiley Periodicals, Inc.</rights><rights>2014 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5445-32be05d946cf3f0506a732356cfdee36e1b9d2fbed92703e2d584b5cbdabdee43</citedby><cites>FETCH-LOGICAL-c5445-32be05d946cf3f0506a732356cfdee36e1b9d2fbed92703e2d584b5cbdabdee43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjmv.23685$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjmv.23685$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,776,780,881,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27720232$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23893753$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pantry, Shara N.</creatorcontrib><creatorcontrib>Medveczky, Maria M.</creatorcontrib><creatorcontrib>Arbuckle, Jesse H.</creatorcontrib><creatorcontrib>Luka, Janos</creatorcontrib><creatorcontrib>Montoya, Jose G.</creatorcontrib><creatorcontrib>Hu, Jianhong</creatorcontrib><creatorcontrib>Renne, Rolf</creatorcontrib><creatorcontrib>Peterson, Daniel</creatorcontrib><creatorcontrib>Pritchett, Joshua C.</creatorcontrib><creatorcontrib>Ablashi, Dharam V.</creatorcontrib><creatorcontrib>Medveczky, Peter G.</creatorcontrib><title>Persistent human herpesvirus-6 infection in patients with an inherited form of the virus</title><title>Journal of medical virology</title><addtitle>J. Med. Virol</addtitle><description>Human herpesvirus‐6 (HHV‐6)A and 6B are ubiquitous betaherpesviruses viruses with lymphotropic and neurotropic potential. As reported earlier, these viruses establish latency by integration into the telomeres of host chromosomes. Chromosomally integrated HHV‐6 (CIHHV‐6) can be transmitted vertically from parent to child. Some CIHHV‐6 patients are suffering from neurological symptoms, while others remain asymptomatic. Four patients with CIHHV‐6 and CNS dysfunction were treated with valganciclovir or foscarnet. HHV‐6 replication was detected by reverse transcriptase polymerase chain reaction amplification of a late envelope glycoprotein. In this study we also compared the inherited and persistent HHV‐6 viruses by DNA sequencing. The prevalence of CIHHV‐6 in this cohort of adult patients from the USA suffering from a wide range of neurological symptoms including long‐term fatigue were found significantly greater than the reported 0.8% in the general population. Long‐term antiviral therapy inhibited HHV‐6 replication as documented by loss of viral mRNA production. Sequence comparison of the mRNA and the inherited viral genome revealed that the transcript is produced by an exogenous virus. In conclusion, the data presented here document that some individuals with CIHHV‐6 are infected persistently with exogenous HHV‐6 strains that lead to a wide range of neurological symptoms; the proposed name for this condition is inherited herpesvirus 6 syndrome or IHS. J Med. Virol. 85:1940–1946, 2013. © 2013 Wiley Periodicals, Inc.</description><subject>Adult</subject><subject>Antiviral Agents - administration & dosage</subject><subject>antiviral drug treatment</subject><subject>Biological and medical sciences</subject><subject>Central nervous system</subject><subject>chronic fatigue syndrome</subject><subject>Cohort Studies</subject><subject>DNA, Viral - genetics</subject><subject>Foscarnet - administration & dosage</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Ganciclovir - administration & dosage</subject><subject>Ganciclovir - analogs & derivatives</subject><subject>Herpesvirus</subject><subject>Herpesvirus 6, Human - isolation & purification</subject><subject>Herpesvirus 6, Human - physiology</subject><subject>HHV-6</subject><subject>human herpesvirus 6</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Infectious Disease Transmission, Vertical</subject><subject>Infectious diseases</subject><subject>integration</subject><subject>Medical sciences</subject><subject>Microbiology</subject><subject>Miscellaneous</subject><subject>Prevalence</subject><subject>RNA, Viral - genetics</subject><subject>Roseolovirus Infections - epidemiology</subject><subject>Roseolovirus Infections - pathology</subject><subject>Roseolovirus Infections - transmission</subject><subject>Roseolovirus Infections - virology</subject><subject>Sequence Analysis, DNA</subject><subject>Treatment Outcome</subject><subject>United States - epidemiology</subject><subject>Viral diseases</subject><subject>Virology</subject><subject>Virus Replication - drug effects</subject><issn>0146-6615</issn><issn>1096-9071</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqN0klv1DAUAGALgegwcOAPIEsICQ5pvcR2cqlUFVqopgWJQrlZTvJCPE3iwU6m9N_jWTosUiVOcZzvLfEzQs8p2aeEsIN5t9xnXGbiAZpQksskJ4o-RBNCU5lIScUeehLCnBCS5Yw9RnuMZzlXgk_Qt0_ggw0D9ANuxs70uAG_gLC0fgyJxLavoRys6-MKL8xgIwz4xg4NNqu9qO0AFa6d77Cr8dAAXsc-RY9q0wZ4tn1O0ZeTd5fH75PZx9MPx0ezpBRpKhLOCiCiylNZ1rwmgkijOOMivlYAXAIt8orVBVQ5U4QDq0SWFqIsKlNEkPIpOtzkXYxFB1UZ-_Om1QtvO-NvtTNW__2lt43-7paaK5VLSWKC19sE3v0YIQy6s6GEtjU9uDFomvKUcJYp9R90xRiVWaQv_6FzN_o-nsRaUcmVpFG92ajSuxA81Lu-KdGr0eo4Wr0ebbQv_vzRnbybZQSvtsCE0rS1N31pw28XOyMsnu0UHWzcjW3h9v6K-uz8613pZBOxuig_dxHGX2upYm19dXGqZ29PPl-dnV_qnP8CBNzLSg</recordid><startdate>201311</startdate><enddate>201311</enddate><creator>Pantry, Shara N.</creator><creator>Medveczky, Maria M.</creator><creator>Arbuckle, Jesse H.</creator><creator>Luka, Janos</creator><creator>Montoya, Jose G.</creator><creator>Hu, Jianhong</creator><creator>Renne, Rolf</creator><creator>Peterson, Daniel</creator><creator>Pritchett, Joshua C.</creator><creator>Ablashi, Dharam V.</creator><creator>Medveczky, Peter G.</creator><general>Blackwell Publishing Ltd</general><general>Wiley</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201311</creationdate><title>Persistent human herpesvirus-6 infection in patients with an inherited form of the virus</title><author>Pantry, Shara N. ; Medveczky, Maria M. ; Arbuckle, Jesse H. ; Luka, Janos ; Montoya, Jose G. ; Hu, Jianhong ; Renne, Rolf ; Peterson, Daniel ; Pritchett, Joshua C. ; Ablashi, Dharam V. ; Medveczky, Peter G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5445-32be05d946cf3f0506a732356cfdee36e1b9d2fbed92703e2d584b5cbdabdee43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Antiviral Agents - administration & dosage</topic><topic>antiviral drug treatment</topic><topic>Biological and medical sciences</topic><topic>Central nervous system</topic><topic>chronic fatigue syndrome</topic><topic>Cohort Studies</topic><topic>DNA, Viral - genetics</topic><topic>Foscarnet - administration & dosage</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Ganciclovir - administration & dosage</topic><topic>Ganciclovir - analogs & derivatives</topic><topic>Herpesvirus</topic><topic>Herpesvirus 6, Human - isolation & purification</topic><topic>Herpesvirus 6, Human - physiology</topic><topic>HHV-6</topic><topic>human herpesvirus 6</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Infectious Disease Transmission, Vertical</topic><topic>Infectious diseases</topic><topic>integration</topic><topic>Medical sciences</topic><topic>Microbiology</topic><topic>Miscellaneous</topic><topic>Prevalence</topic><topic>RNA, Viral - genetics</topic><topic>Roseolovirus Infections - epidemiology</topic><topic>Roseolovirus Infections - pathology</topic><topic>Roseolovirus Infections - transmission</topic><topic>Roseolovirus Infections - virology</topic><topic>Sequence Analysis, DNA</topic><topic>Treatment Outcome</topic><topic>United States - epidemiology</topic><topic>Viral diseases</topic><topic>Virology</topic><topic>Virus Replication - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pantry, Shara N.</creatorcontrib><creatorcontrib>Medveczky, Maria M.</creatorcontrib><creatorcontrib>Arbuckle, Jesse H.</creatorcontrib><creatorcontrib>Luka, Janos</creatorcontrib><creatorcontrib>Montoya, Jose G.</creatorcontrib><creatorcontrib>Hu, Jianhong</creatorcontrib><creatorcontrib>Renne, Rolf</creatorcontrib><creatorcontrib>Peterson, Daniel</creatorcontrib><creatorcontrib>Pritchett, Joshua C.</creatorcontrib><creatorcontrib>Ablashi, Dharam V.</creatorcontrib><creatorcontrib>Medveczky, Peter G.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of medical virology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pantry, Shara N.</au><au>Medveczky, Maria M.</au><au>Arbuckle, Jesse H.</au><au>Luka, Janos</au><au>Montoya, Jose G.</au><au>Hu, Jianhong</au><au>Renne, Rolf</au><au>Peterson, Daniel</au><au>Pritchett, Joshua C.</au><au>Ablashi, Dharam V.</au><au>Medveczky, Peter G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Persistent human herpesvirus-6 infection in patients with an inherited form of the virus</atitle><jtitle>Journal of medical virology</jtitle><addtitle>J. Med. Virol</addtitle><date>2013-11</date><risdate>2013</risdate><volume>85</volume><issue>11</issue><spage>1940</spage><epage>1946</epage><pages>1940-1946</pages><issn>0146-6615</issn><eissn>1096-9071</eissn><coden>JMVIDB</coden><abstract>Human herpesvirus‐6 (HHV‐6)A and 6B are ubiquitous betaherpesviruses viruses with lymphotropic and neurotropic potential. As reported earlier, these viruses establish latency by integration into the telomeres of host chromosomes. Chromosomally integrated HHV‐6 (CIHHV‐6) can be transmitted vertically from parent to child. Some CIHHV‐6 patients are suffering from neurological symptoms, while others remain asymptomatic. Four patients with CIHHV‐6 and CNS dysfunction were treated with valganciclovir or foscarnet. HHV‐6 replication was detected by reverse transcriptase polymerase chain reaction amplification of a late envelope glycoprotein. In this study we also compared the inherited and persistent HHV‐6 viruses by DNA sequencing. The prevalence of CIHHV‐6 in this cohort of adult patients from the USA suffering from a wide range of neurological symptoms including long‐term fatigue were found significantly greater than the reported 0.8% in the general population. Long‐term antiviral therapy inhibited HHV‐6 replication as documented by loss of viral mRNA production. Sequence comparison of the mRNA and the inherited viral genome revealed that the transcript is produced by an exogenous virus. In conclusion, the data presented here document that some individuals with CIHHV‐6 are infected persistently with exogenous HHV‐6 strains that lead to a wide range of neurological symptoms; the proposed name for this condition is inherited herpesvirus 6 syndrome or IHS. J Med. Virol. 85:1940–1946, 2013. © 2013 Wiley Periodicals, Inc.</abstract><cop>Hoboken, NJ</cop><pub>Blackwell Publishing Ltd</pub><pmid>23893753</pmid><doi>10.1002/jmv.23685</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0146-6615 |
| ispartof | Journal of medical virology, 2013-11, Vol.85 (11), p.1940-1946 |
| issn | 0146-6615 1096-9071 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3779660 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adult Antiviral Agents - administration & dosage antiviral drug treatment Biological and medical sciences Central nervous system chronic fatigue syndrome Cohort Studies DNA, Viral - genetics Foscarnet - administration & dosage Fundamental and applied biological sciences. Psychology Ganciclovir - administration & dosage Ganciclovir - analogs & derivatives Herpesvirus Herpesvirus 6, Human - isolation & purification Herpesvirus 6, Human - physiology HHV-6 human herpesvirus 6 Human viral diseases Humans Infectious Disease Transmission, Vertical Infectious diseases integration Medical sciences Microbiology Miscellaneous Prevalence RNA, Viral - genetics Roseolovirus Infections - epidemiology Roseolovirus Infections - pathology Roseolovirus Infections - transmission Roseolovirus Infections - virology Sequence Analysis, DNA Treatment Outcome United States - epidemiology Viral diseases Virology Virus Replication - drug effects |
| title | Persistent human herpesvirus-6 infection in patients with an inherited form of the virus |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-10T06%3A01%3A25IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Persistent%20human%20herpesvirus-6%20infection%20in%20patients%20with%20an%20inherited%20form%20of%20the%20virus&rft.jtitle=Journal%20of%20medical%20virology&rft.au=Pantry,%20Shara%20N.&rft.date=2013-11&rft.volume=85&rft.issue=11&rft.spage=1940&rft.epage=1946&rft.pages=1940-1946&rft.issn=0146-6615&rft.eissn=1096-9071&rft.coden=JMVIDB&rft_id=info:doi/10.1002/jmv.23685&rft_dat=%3Cproquest_pubme%3E1428772168%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1428163761&rft_id=info:pmid/23893753&rfr_iscdi=true |