Molecular Architecture of the Ankyrin SOCS Box Family of Cul5-Dependent E3 Ubiquitin Ligases

Multi-subunit Cullin–RING E3 ligases often use repeat domain proteins as substrate-specific adaptors. Structures of these macromolecular assemblies are determined for the F-box-containing leucine-rich repeat and WD40 repeat families, but not for the suppressor of cytokine signaling (SOCS)-box-contai...

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Veröffentlicht in:	Journal of molecular biology 2013-09, Vol.425 (17), p.3166-3177
Hauptverfasser:	Muniz, João R.C., Guo, Kunde, Kershaw, Nadia J., Ayinampudi, Vikram, von Delft, Frank, Babon, Jeffrey J., Bullock, Alex N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Ankyrins - chemistry Ankyrins - genetics Ankyrins - metabolism Binding Sites creatine crystal structure Crystallography, X-Ray Cullin Proteins - chemistry Cullin Proteins - genetics Cullin Proteins - metabolism cytokines degradation Humans kinases ligases Mice Molecular Sequence Data proteasome Protein Binding protein–protein interaction Sequence Alignment signaling Suppressor of Cytokine Signaling Proteins - chemistry Suppressor of Cytokine Signaling Proteins - genetics Suppressor of Cytokine Signaling Proteins - metabolism ubiquitin Ubiquitin-Protein Ligases - chemistry Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - metabolism ubiquitination
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