Contaminated Heparin Associated with Adverse Clinical Events and Activation of the Contact System

Recently the heparin supply in 12 countries was found to be contaminated with a substance that caused hypotension and, in some cases, death. The contaminant has been identified as oversulfated chondroitin sulfate (OSCS). This study shows that OSCS can activate the kinin–kallikrein pathway and the co...

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Veröffentlicht in:	The New England journal of medicine 2008-06, Vol.358 (23), p.2457-2467
Hauptverfasser:	Kishimoto, Takashi Kei, Viswanathan, Karthik, Ganguly, Tanmoy, Elankumaran, Subbiah, Smith, Sean, Pelzer, Kevin, Lansing, Jonathan C, Sriranganathan, Nammalwar, Zhao, Ganlin, Galcheva-Gargova, Zoya, Al-Hakim, Ali, Bailey, Gregory Scott, Fraser, Blair, Roy, Sucharita, Rogers-Cotrone, Thomas, Buhse, Lucinda, Whary, Mark, Fox, James, Nasr, Moheb, Dal Pan, Gerald J, Shriver, Zachary, Langer, Robert S, Venkataraman, Ganesh, Austen, K. Frank, Woodcock, Janet, Sasisekharan, Ram
Format:	Artikel
Sprache:	eng
Schlagworte:	Anaphylaxis - chemically induced Animals Biological and medical sciences China Chondroitin Sulfates - adverse effects Chondroitin Sulfates - analysis Chondroitin Sulfates - pharmacology Complement Activation - drug effects Complement C3a - biosynthesis Complement C3a - drug effects Complement C5a - biosynthesis Complement C5a - drug effects Drug Contamination Drug Industry Drug therapy Family medical history Female General aspects Germany Hemodialysis Heparin - adverse effects Heparin - chemistry Humans Hypotension - chemically induced Kallikreins - drug effects Kallikreins - metabolism Medical sciences Middle Aged Sus scrofa United States United States Food and Drug Administration
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