The Xist lncRNA exploits three-dimensional genome architecture to spread across the X chromosome

Many large noncoding RNAs (lncRNAs) regulate chromatin, but the mechanisms by which they localize to genomic targets remain unexplored. We investigated the localization mechanisms of the Xist lncRNA during X-chromosome inactivation (XCI), a paradigm of lncRNA-mediated chromatin regulation. During th...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2013-08, Vol.341 (6147), p.1237973-1237973
Hauptverfasser:	Engreitz, Jesse M, Pandya-Jones, Amy, McDonel, Patrick, Shishkin, Alexander, Sirokman, Klara, Surka, Christine, Kadri, Sabah, Xing, Jeffrey, Goren, Alon, Lander, Eric S, Plath, Kathrin, Guttman, Mitchell
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Differentiation Cell Line Chromatin - chemistry Chromatin - metabolism Chromosomes Female Females Genes Genome Genomes Government regulations Inactivation Male Mice Models, Genetic Ribonucleic acids RNA, Long Noncoding - chemistry RNA, Long Noncoding - metabolism Three dimensional Transcription, Genetic X Chromosome - metabolism X Chromosome - ultrastructure X Chromosome Inactivation
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