Characterization of Maleimide-Based Glycogen Synthase Kinase‑3 (GSK-3) Inhibitors as Stimulators of Steroidogenesis

Inhibition of GSK-3β has been well documented to account for the behavioral actions of the mood stabilizer lithium in various animal models of mood disorders. Recent studies have showed that genetic or pharmacological inhibition of GSK-3β resulted in anxiolytic-like and pro-social behavior. In our o...

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Veröffentlicht in:	Journal of medicinal chemistry 2013-06, Vol.56 (12), p.5115-5129
Hauptverfasser:	Gunosewoyo, Hendra, Midzak, Andrew, Gaisina, Irina N, Sabath, Emily V, Fedolak, Allison, Hanania, Taleen, Brunner, Dani, Papadopoulos, Vassilios, Kozikowski, Alan P
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism Animals Binding, Competitive Cell Line, Tumor Glycogen Synthase Kinase 3 - antagonists & inhibitors Humans Maleimides - chemistry Maleimides - metabolism Maleimides - pharmacology Mice Protein Kinase Inhibitors - chemistry Protein Kinase Inhibitors - metabolism Protein Kinase Inhibitors - pharmacology Steroids - biosynthesis
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